단트롤렌 나트륨

동물 종별 용량

투여 경로

금기

• Preexisting liver disease (use with extreme caution)
• Severe cardiac dysfunction (use with caution)
• Pulmonary disease (use with caution)

이상반응

• Weakness
• Sedation
• Dizziness
• Headache
• Nausea
• Vomiting
• Constipation
• Increased urinary frequency
• Hypotension
• Hepatotoxicity (especially with chronic use)

약물 상호작용

• Benzodiazepines & other CNS depressants · Increased sedation may be seen if tranquilizing agents are used concomitantly.
• Calcium-Channel Blockers · Rare reports of cardiovascular collapse in humans; concomitant use during malignant hyperthermia crises is not recommended. · major
• Estrogens · Increased risks of hepatotoxicity have been seen in women >35 years of age; veterinary significance is unknown.
• Warfarin · Dantrolene may be displaced from plasma proteins by warfarin, resulting in increased effects or adverse reactions.

모니터링

• Baseline and periodic liver function tests (ALT, AST, Alk Phos, etc.) if projecting to be used chronically or using high dosages
• Body temperature (especially for malignant hyperthermia)
• Urine volume, frequency, continence

과용량

There is no specific antidotal therapy for dantrolene overdoses. * **Decontamination:** Remove the drug from the gut if possible (e.g., emesis induction, activated charcoal) if exposure was recent and oral. * **Supportive Care:** Treat supportively, monitoring respiratory, cardiovascular, and hepatic function.