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λ΅μ(Dapsone)μ **μ€ν°κ³ νκ· μ ** λ° **νμΌμ¦μ **μ λλ€. μμνμμλ μ£Όλ‘ νΉμ λ©΄μ 맀κ°μ± νΌλΆ μ§ν(μ: μ²ν¬μ°½, νΌλΆ νκ΄μΌ) λ° λΉμ ν κ°μΌ(μ: λ§μ΄μ½λ°ν 리μ, νν¬μμΆ©)μ λν **2μ°¨ λλ 보쑰 μλ²**μΌλ‘ μ¬μ©λ©λλ€. > **μμ μμ **: **κ°λ μ±** λ° **νμ‘ μ§ν**κ³Ό κ°μ μ¬κ°ν λΆμμ© λ°μ μνμ΄ λκΈ° λλ¬Έμ 1μ°¨ μ νμ½μΌλ‘ μ¬μ©λλ κ²½μ°λ λλ λλ€. κ³ μμ΄λ λ©νΈν€λͺ¨κΈλ‘λΉνμ¦ λ° μ©νμ± λΉνμ λν κ°μμ±μ΄ λ§€μ° λμΌλ―λ‘ κ³ μμ΄μκ²λ **μλμ κΈκΈ°**λ‘ κ°μ£Όλ©λλ€.
μμ© κΈ°μ : **Antimicrobial action**: Acts as a competitive antagonist of **para-aminobenzoic acid (PABA)**. It inhibits the enzyme **dihydropteroate synthase (DHPS)** β blocks the synthesis of **dihydrofolic acid** β disrupts nucleic acid synthesis in susceptible organisms (similar to sulfonamides). **Anti-inflammatory action**: Dapsone exerts potent immunomodulatory effects. It inhibits the **myeloperoxidase-H2O2-halide system** β suppresses the **neutrophil respiratory burst**. It also decreases **neutrophil chemotaxis**, complement activation, antibody production, and lysosomal enzyme synthesis, making it useful for sterile, neutrophil-driven inflammatory conditions like vasculitis or Brown Recluse spider bites.
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- Alternative to clofazimine for treating feline leprosy Β· 1 mg/kg once daily PO Β· PO Β· q24h Β· Caution: High risk of serious side effects. Intensive monitoring required.
- Treating mycobacteriosis Β· 8 mg/kg PO once daily for 6 weeks Β· PO Β· q24h Β· 6 weeks Β· Caution: High risk of serious side effects. Intensive monitoring required.
- Aural chondritis Β· 1 mg/kg PO q24h Β· PO Β· q24h Β· Caution: High risk of serious side effects. Intensive monitoring required.
- Alternative treatment for Pneumocystis carinii pneumonia Β· 3 mg/kg PO once daily (q24h) Β· PO Β· q24h Β· 56 days Β· From one case report of treatment of a foal.
- Alternative treatment for pemphigus Β· 1 mg/kg PO q8h; with sulfasalazine at 10-40 mg/kg q8h Β· PO Β· q8h
- Post-vaccination alopecia/vasculitis resistant to prednisone therapy Β· 1 mg/kg PO q8h Β· PO Β· q8h
- Treating mycobacteriosis Β· 1.1 mg/kg PO q6h until remission, then 0.3 mg/kg q8-12h after recovery Β· PO Β· q6h initially, then q8-12h Β· Until remission, then maintenance
- Adjunctive therapy of vasculitis Β· 1 mg/kg PO q8h Β· PO Β· q8h
- Adjunctive treatment of Brown Recluse spider (Loxosceles spp.) bite Β· 1 mg/kg PO three times daily for 10 days Β· PO Β· TID Β· 10 days
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- Cats (relatively contraindicated due to high risk of neurotoxicity and hemolytic anemia)
- Hypersensitivity to dapsone or other sulfone drugs
- Patients with severe anemias or preexisting blood dyscrasias
- Preexisting hepatic dysfunction (use with extreme caution)
μ΄μλ°μ
- Hepatotoxicity
- Dose-dependent methemoglobinemia
- Hemolytic anemia
- Thrombocytopenia
- Neutropenias
- Gastrointestinal effects (nausea, vomiting)
- Neuropathies
- Cutaneous drug eruptions
- Photosensitivity
- Potential carcinogen
μ½λ¬Ό μνΈμμ©
- Probenecid Β· May decrease the renal excretion of active metabolites of dapsone.
- Pyrimethamine Β· May increase risk of hematologic reactions occurring with dapsone.
- Rifampin Β· May decrease plasma dapsone concentrations (7-10 fold).
- Trimethoprim Β· May increase plasma dapsone concentrations (and vice versa) and potentially increase each other's toxicity.
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- CBC with platelets every 2-3 weeks during first 4 months of treatment, then every 3-4 months
- Liver function tests
- Clinical signs of adverse effects (GI upset, drug eruptions, neurotoxicity, jaundice, cyanosis)
- Clinical efficacy
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Because of its toxicity potential, specific species differences in sensitivity, and pharmacokinetics, it is recommended to contact an animal poison control center in cases of dapsone overdoses. - **Clinical Signs**: In humans, overdoses generally cause nausea, vomiting, and hyperexcitability within minutes. **Methemoglobinemia** with associated depression, seizures, and cyanosis can occur. **Hemolysis** may be delayed, occurring 7-14 days after the overdose. - **Treatment**: Includes removal of drug from the gut (decontamination), **methylene blue** for methemoglobinemia, and sometimes hemodialysis to enhance removal of the drug and its monoacetyl metabolite.
VetSheet μ½λ¬Ό λ νΌλ°μ€λ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μμ¬κ²°μ 보쑰 λꡬμ΄λ©°, μ λ¬Έμ νλ¨μ΄λ μ μ‘°μ¬μ μ΅μ λΌλ²¨μ λμ νμ§ μμ΅λλ€.