데스플루란
데스플루란은 할로겐화 휘발성 흡입 마취제로, 이소플루란과 매우 유사한 화학 구조를 가지고 있습니다. 가장 큰 임상적 장점은 **매우 빠른 마취 유도 및 회복**입니다. 끓는점이 실온과 비슷하여 전용 가열 및 가압 기화기가 필요합니다. 자극적인 냄새가 있어 마스크 유도에는 적합하지 않습니다.
작용 기전: While the exact mechanism of inhalant anesthetics remains incompletely understood, desflurane is believed to produce general anesthesia by interacting with the **lipid matrix of neuronal membranes** and modulating multiple ligand-gated ion channels in the central nervous system. **Mechanistic Pathways:** * **GABA_A and Glycine Receptors:** Potentiates inhibitory neurotransmission → CNS depression. * **NMDA Receptors:** Inhibits excitatory glutamatergic transmission. **Minimum Alveolar Concentration (MAC) in Oxygen:** * Dogs: 7% * Cats: 9.8% * Horses: 7.23% * Rabbits: 8.9% * Alpacas/Llamas: 7.8-8.0% *Note: Desflurane causes dose-dependent cardiovascular (hypotension) and respiratory depression, but does not sensitize the myocardium to catecholamine-induced arrhythmias.*
동물 종별 용량
- General Anesthesia (Clinically useful concentrations) · Induction = 8-15%; Maintenance = 5-9% · Inhalation · Continuous · As needed
- General Anesthesia (Emergency patients) · 6% · Inhalation · Continuous · As needed · Approximate MAC for emergency patients
- General Anesthesia (Following IV induction) · start with a vaporiser setting of about 8% (around MAC in most animals), increasing the concentration as required. · Inhalation · Continuous · As needed
- General Anesthesia (Clinically useful concentrations) · Induction = 8-15%; Maintenance = 5-9% · Inhalation · Continuous · As needed
- General Anesthesia (Emergency patients) · 6% · Inhalation · Continuous · As needed · Approximate MAC for emergency patients
- General Anesthesia (Following IV induction) · start with a vaporiser setting of about 8% (around MAC in most animals), increasing the concentration as required. · Inhalation · Continuous · As needed
용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.
투여 경로
금기
- Hypersensitivity to desflurane or other halogenated anesthetic agents
- History of or predilection towards malignant hyperthermia
이상반응
- Hypotension (dose-dependent)
- Respiratory depression (dose-dependent)
- Respiratory irritation and salivation (especially with mask induction)
- Sympathetic stimulation (tachycardia/hypertension) with rapid increases in concentration
- Malignant hyperthermia (in susceptible individuals, though incidence may be lower than other halogenated agents)
- Transient increases in glucose and white blood cell count
약물 상호작용
- ACE Inhibitors or other hypotensive agents · Concomitant use may increase risks for severe hypotension.
- Non-depolarizing neuromuscular blocking agents · Additive neuromuscular blockade may occur.
- Succinylcholine · May induce increased incidences of cardiac effects (bradycardia, arrhythmias, sinus arrest, apnea) and trigger malignant hyperthermia in susceptible patients.
모니터링
- Respiratory rate, rhythm, and ventilatory status (capnography)
- Cardiac rate and rhythm (ECG)
- Arterial blood pressure
- Level of anesthetic depth (jaw tone, palpebral reflex)
- Body temperature
- Neuromuscular function
과용량
In the event of an overdosage, immediately **discontinue desflurane**. Maintain a patent airway and provide positive pressure ventilation with 100% oxygen. Support cardiovascular function with intravenous fluids and sympathomimetics as necessary.
VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.