데슬로렐린

호르몬제 / GnRH 유사체

**데슬로렐린 아세테이트(Deslorelin acetate)**는 강력한 합성 성선자극호르몬 방출호르몬(GnRH) 유사체입니다. 수의학에서는 제형과 노출 기간에 따라 두 가지 상반된 목적으로 사용됩니다: * **단기 사용 (배란 유도):** 암말에서 단기 작용 주사 현탁액이나 제거 가능한 임플란트를 사용하여 배란을 유도하고 시기를 정확히 맞춰 번식 성공률을 높입니다. * **장기 사용 (내과적 거세/피임):** 서방형 임플란트는 지속적인 GnRH 자극을 제공하여 궁극적으로 생식축을 억제합니다. 이는 수컷 반려견의 가역적 피임에 사용되며, 오프라벨(허가 외)로 양성 전립선 비대증(BPH) 및 난소 절제된 암컷 반려견의 요실금 관리에도 사용됩니다. > **임상 팁:** 모든 지역에서 명시적으로 허가된 것은 아니지만, 데슬로렐린 임플란트(Suprelorin)는 **페럿의 부신 질환** 치료의 표준으로 널리 간주되며, 특수 동물 및 동물원 동물의 번식 제어를 위해 오프라벨로 자주 사용됩니다.

작용 기전: Deslorelin acts as an agonist at **GnRH receptors** in the anterior pituitary gland. Its clinical effect depends entirely on the duration of administration: * **Acute Administration (Flare Effect):** Initial binding to GnRH receptors stimulates a rapid surge in the release of **luteinizing hormone (LH)** and **follicle-stimulating hormone (FSH)**. * *Pathway:* Deslorelin → Pituitary GnRH receptors → ↑ LH/FSH surge → **Induction of ovulation** (in mares with mature follicles >30 mm). * **Continuous Administration (Downregulation):** When provided as a sustained-release implant, the continuous presence of the GnRH analog overstimulates the receptors. * *Pathway:* Continuous deslorelin → **Internalization and downregulation of GnRH receptors** → Profound suppression of LH and FSH secretion → Decreased production of gonadal steroids (testosterone/estrogen) → **Reversible chemical castration/contraception**.

동물 종별 용량

Horses

Induction of ovulation (follicle 30-40 mm in diameter) · 1.8 mg (1 mL) · IM · Once · Single dose · Administer in the neck. Shake vial well before drawing into syringe.
Induction of ovulation (follicle >30 mm in diameter) · 1 implant (2.1 mg) · SC · Once · Remove after 48h · Implant SC in the neck. Remove after approx 48 hours to prevent prolonged interovulatory interval. Alternative: Infuse 1 mL lidocaine into vulvar edge, insert implant beneath epithelium. Squeeze out after ovulation.

Dogs

Contraceptive in male dogs · 4.7 mg implant SC every 6 months OR 9.4 mg implant SC every 12 months · SC · q6mo or q12mo · Continuous · Implant in loose skin between lower neck and lumbar area; avoid implanting into fat. Pregnant women should not administer the implant.
Temporary chemical castration · 1 implant (4.7 mg or 9.4 mg) per male dog · SC · repeat after 6 or 12 months · 6 to 12 months depending on implant size · Dogs <10 kg may take up to 18 months to recover testosterone. Separation from females in heat required for first 6 weeks.

Cats

Temporary chemical castration · 1 implant (4.7 mg) per male cat · SC · once · 2-4 years · Causes chemical castration for 2-4 years in tom cats.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

IMSCSubmucosal (vulvar - off-label for easy removal)

금기

Known hypersensitivity to deslorelin
Horses intended for human consumption
Intravenous (IV) administration
Administration by pregnant women (implants)

이상반응

Local swelling, pain, and elevated skin temperature at the injection/implant site (usually resolves within 5 days)
Prolonged interovulatory period in mares if the 2.1 mg implant is not removed
Initial transient increase in sexual behavior or clinical signs (flare effect) before suppression occurs (with long-acting implants)

모니터링

Follicle size via ultrasound or rectal palpation (mares)
Injection/implant site for severe swelling or reaction
Resolution of clinical signs or reduction in testicular size (when used for contraception in dogs)

과용량

In mares receiving a single IM injection at 10X the recommended dose (18 mg), moderate tremors and hives were observed 6 hours after injection in one out of eight horses. If an inadvertent additional implant is administered, it should be removed upon detection if within 96 hours of implantation.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.