디클로페낙 나트륨

비스테로이드성 항염증제 (NSAID)

디클로페낙 나트륨은 **비스테로이드성 항염증제(NSAID)**입니다. - **수의학적 용도**: 말의 골관절염과 관련된 국소 관절 통증 및 염증을 조절하기 위한 국소 리포솜 크림(Surpass®)으로 FDA 승인을 받았습니다. - **전신 사용**: 이론적으로 다른 종에 전신 투여할 수 있지만, 개와 고양이를 위한 더 안전한 FDA 승인 대안이 있습니다. > **중요 독성 주의**: 디클로페낙은 조류(특히 독수리)에게 매우 독성이 강하여 치명적인 신부전을 유발하므로 조류에게 절대 사용해서는 안 됩니다.

작용 기전: Diclofenac is a non-specific inhibitor of **cyclooxygenase (COX-1 and COX-2)** enzymes. - **Arachidonic Acid Cascade**: Inhibits the conversion of arachidonic acid → **prostaglandins** and **thromboxanes**. - **Lipooxygenase**: May also have some inhibitory effects on the lipooxygenase pathway, reducing leukotriene production. - **Result**: Decreased production of inflammatory mediators leads to reduced pain, hyperpyrexia, and inflammation.

동물 종별 용량

Horses

Control of pain and inflammation associated with osteoarthritis in tarsal, carpal, metacarpophalangeal, metarsophalangeal, and proximal interphalangeal (hock, knee, fetlock, pastern) joints · Apply a five inch ribbon · topical · twice daily · up to 10 days · Wear rubber gloves and rub cream thoroughly into the hair covering the joint until cream disappears.

Dogs

Ocular inflammation / Uveitis · 1 drop per affected eye · topical · bid to qid · As directed by veterinarian · Standard veterinary ophthalmic dosing; not explicitly stated in the provided monograph.

Cats

Ocular inflammation / Uveitis · 1 drop per affected eye · topical · bid to qid · As directed by veterinarian · Standard veterinary ophthalmic dosing; not explicitly stated in the provided monograph.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

topicalPOophthalmic

금기

Hypersensitivity to diclofenac or any component of the cream
Horses less than one year old
Birds (implicated in causing death in vultures)

이상반응

Colic (horses)
Weight loss
Gastric ulcers
Diarrhea
Uterine discharge
Local inflammation
Swelling
Alopecia
Vomiting (dogs/cats)
Bloody diarrhea/melena (dogs/cats)
Polydipsia (dogs/cats)

약물 상호작용

Topical Corticosteroids · Increased risk of delayed corneal healing and severe corneal complications (corneal melting) when used concurrently. · major
Topical Prostaglandin Analogues (e.g., Latanoprost) · NSAIDs may theoretically blunt the intraocular pressure-lowering effect of prostaglandin analogues. · moderate

모니터링

Efficacy (reduction in pain/inflammation)
Adverse effects (GI signs, local skin reactions)

과용량

As an NSAID, overdosage primarily affects the **gastrointestinal** and **renal** systems. - **Horses (Topical Overdose)**: Weight loss, gastric ulcers, colic, diarrhea, and uterine discharge. - **Dogs/Cats (Ingestion)**: Vomiting, diarrhea (often bloody/melena), and polydipsia. - **Treatment**: - **Decontamination**: Emetics and/or activated charcoal for recent ingestions. - **GI Protection**: Use of gastrointestinal protectants (e.g., sucralfate, omeprazole) is warranted if GI effects are expected. - **Renal Protection**: Fluid diuresis is warranted if renal effects are anticipated. - **Supportive Care**: Symptomatic treatment as needed.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.