디클록사실린

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Hypersensitivity to penicillins
• Septicemia, shock, or other grave illnesses (oral absorption may be significantly delayed or diminished)

이상반응

• Anorexia
• Vomiting
• Diarrhea
• Antibiotic-associated diarrhea (superinfections)
• Hypersensitivity reactions (rashes, fever, eosinophilia, anaphylaxis)
• Neurotoxicity (ataxia at very high doses)
• Elevated liver enzymes
• Tachypnea
• Dyspnea
• Edema
• Tachycardia

약물 상호작용

• Aminoglycosides · In vitro evidence of synergism with dicloxacillin against S. aureus strains; however, penicillins can inactivate aminoglycosides in vitro, so do not mix in the same syringe/fluid line.
• Cyclosporine · Dicloxacillin may reduce cyclosporine levels.
• Probenecid · Competitively blocks the tubular secretion of dicloxacillin, thereby increasing serum levels and serum half-lives.
• Tetracyclines · Theoretical antagonism; concurrent use is usually not recommended.
• Warfarin · Dicloxacillin may cause decreased warfarin efficacy.

모니터링

• Clinical efficacy (resolution of infection)
• Toxic clinical signs (GI upset, hypersensitivity)

과용량

Acute oral penicillin overdoses are unlikely to cause significant problems other than **GI distress** (vomiting, diarrhea). In humans, very high dosages of parenteral penicillins, especially in patients with renal disease, have induced **CNS effects** (neurotoxicity).