디멘히드리네이트

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Hypersensitivity to dimenhydrinate or other antihistamines in its class
• Angle closure glaucoma (use with caution)
• Prostatic hypertrophy (use with caution)
• Pyloroduodenal or bladder neck obstruction (use with caution)
• COPD if mucosal secretions are a problem (use with caution)
• Hyperthyroidism, seizure disorders, cardiovascular disease, or hypertension (use with caution)

이상반응

• CNS depression (lethargy, somnolence)
• Anticholinergic effects (dry mouth, urinary retention)
• GI effects (diarrhea, vomiting, anorexia - less common)

약물 상호작용

• Anticholinergic drugs (e.g., tricyclic antidepressants) · May potentiate the anticholinergic effects of other anticholinergic drugs.
• CNS Depressant Drugs · Increased sedation can occur if combined with other CNS depressants.
• Ototoxic Drugs (e.g., aminoglycosides) · May mask the clinical signs of ototoxicity; use with caution when administering concomitantly.

모니터링

• Clinical efficacy (reduction in vomiting/motion sickness)
• Adverse effects (sedation, anticholinergic signs such as dry mouth or urinary retention)

과용량

Overdosage may cause **CNS stimulation** (excitement to seizures) or **depression** (lethargy to coma), anticholinergic effects, respiratory depression, and death. **Treatment:** * Empty the gut if ingestion was oral. Induce emesis if the patient is alert and CNS status is stable. * Administration of a saline cathartic and/or activated charcoal may be given after emesis or gastric lavage. * Symptomatic and supportive therapies. * **Phenytoin (IV)** is recommended in the treatment of seizures caused by antihistamine overdose in humans; use of barbiturates and diazepam are avoided.