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λλ Ένλ‘μ€νΈ νΈλ‘λ©νλ―Όμ **νλ‘μ€νκΈλλ F2 μν(PGF2Ξ±)**μ ν©μ± μ μ¬μ²΄μ λλ€. μμνμμλ μ£Όλ‘ **μκΆ μμΆ**μ μκ·Ήνκ³ **μκΆκ²½λΆ μ΄μ**μ μ λνλ μκΆμμΆ μμ©μ μν΄ μ¬μ©λλ©°, **κ°λ°©ν μκΆμΆλμ¦**μ ν΅μ¬ μΉλ£μ μ λλ€. > **κ²½κ³ :** κΈ°κ΄μ§ κ²½λ ¨μ΄λ μ μ°μ μ λ°ν μνμ΄ μμΌλ―λ‘ μμ°λΆμ μ²μ νμλ μ΄ μ½λ¬Όμ μ·¨κΈμ μ격ν νΌν΄μΌ ν©λλ€. **μμ ν:** μλλ¬Όμμ λͺ μλ μ£Όμ μ μμ¦μ κ°λ°©ν μκΆμΆλμ¦μ΄μ§λ§, PGF2Ξ±λ λλλ¬Όμ ν©μ²΄ μ΅ν΄(ν©μ²΄ ν΄ν)μ λ리 μ¬μ©λλ©° μλλ¬Όμ μμ μ€μ μ μν΄ κ°νΉ μ¬μ©λκΈ°λ ν©λλ€.
μμ© κΈ°μ : Dinoprost acts directly on the myometrium and corpus luteum. * Binds to specific **FP receptors** on smooth muscle cells. * β Increases intracellular calcium concentrations. * β Induces strong, rhythmic **uterine contractions**. * β Concurrently causes **cervical relaxation** to allow expulsion of uterine contents. * β Induces luteolysis (regression of the corpus luteum), leading to a rapid drop in progesterone levels.
λλ¬Ό μ’ λ³ μ©λ
- Open pyometra / Uterine contraction Β· 0.1 or 0.25 mg/kg Β· SC Β· q12-24h
- Open pyometra Β· 0.1-0.25 mg/kg Β· SC Β· q12h Β· until the uterus is empty; usually 3-5 days treatment required
μ©λμ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μ°Έκ³ μλ£μ λλ€. νμ μ΅μ λΌλ²¨κ³Ό κ°λ³ νμμ λν΄ νμΈνμμμ€.
ν¬μ¬ κ²½λ‘
κΈκΈ°
- Closed pyometra (due to severe risk of uterine rupture)
- Pregnancy (unless abortion is the intended outcome)
- Patients with respiratory disease/asthma (due to bronchoconstriction risk)
μ΄μλ°μ
- Hypersalivation (drooling)
- Panting
- Tachycardia
- Vomiting
- Urination
- Defecation
- Transient hyperthermia
- Locomotor incoordination
- Mild CNS signs
λͺ¨λν°λ§
- Resolution of pyometra (via ultrasound and monitoring of vaginal discharge)
- Heart rate and respiratory rate post-injection
- Signs of excessive distress or hyperthermia
κ³Όμ©λ
Overdosage can lead to an exaggeration of the expected side effects, including severe vomiting, diarrhea, profound tachycardia, hyperthermia, and severe panting. In cases of closed pyometra, excessive doses or any use can cause **uterine rupture** and subsequent fatal peritonitis. Treatment is largely supportive as the drug has a very short half-life.
VetSheet μ½λ¬Ό λ νΌλ°μ€λ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μμ¬κ²°μ 보쑰 λꡬμ΄λ©°, μ λ¬Έμ νλ¨μ΄λ μ μ‘°μ¬μ μ΅μ λΌλ²¨μ λμ νμ§ μμ΅λλ€.