디노프로스트 트로메타민
Dinoprost Tromethamine
Prostaglandin F2alpha tromethamine
다른 이름: Lutalyse · In-Synch · Amtech Prostamate · idinoprostum trometamoli · PGF(2alpha) THAM · prostaglandin F(2alpha) trometamol · U-14583E
VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
동물 종별 용량
🌎 NA — North America🌍 EU — Europe
개
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Treatment of pyometra (open cervix, non-critically ill, ≤6 years old) | Day 1: 0.1 mg/kg SC once; Day 2: 0.2 mg/kg SC once; Days 3-7: 0.25 mg/kg SC once daily | SC | once daily (escalating dose) | 7 days | 🌎 NA |
| Abortifacient (After day 25 or 30) | maximum dosage of 80-100 micrograms/kg SC twice a day | SC | q12h | 6 days or longer | 🌎 NA |
| Adjunctive therapy for termination of mid-term pregnancy | 0.1 mg/kg SC three times daily for 3 days and then 0.2 mg/kg SC three times daily to effect | SC | q8h | to effect | 🌎 NA |
- Treatment of pyometra (open cervix, non-critically ill, ≤6 years old): Use concurrent antibiotics for 14 days after completion. Reevaluate at 7 and 14 days.
- Abortifacient (After day 25 or 30): Start with half the dose for the first day. Monitor side effects carefully.
- Adjunctive therapy for termination of mid-term pregnancy: Given concurrently with 1-3 micrograms/kg misoprostol intravaginally once daily.
고양이
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Treatment of pyometra | Initially 0.1 mg/kg SC, then 0.25 mg/kg SC once a day for 5 days | SC | once daily | 6 days total | 🌎 NA |
| Abortifacient | 2 mg (total dose) per cat IM once a day beginning at day 33 | IM | once daily | Not specified | 🌎 NA |
- Treatment of pyometra: Give bactericidal antibiotics concurrently. Not recommended in animals >8 yrs old.
- Abortifacient: Side effects include prostration, vomiting and diarrhea.
말
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Difficult to breed mares / Controlling time of estrus | 1 mg per 45 kg body weight IM | IM | once | once | 🌎 NA |
| Luteolysis and to stimulate uterine contractions | 10 mg (total dose) IM once | IM | once | once | 🌎 NA |
| Abortifacient (Prior to 12th day of pregnancy) | 5 mg IM | IM | once | once | 🌎 NA |
| Abortifacient (After 4th month of pregnancy) | 1 mg per 45 kg body weight (1 mg per 100 pounds) daily until abortion takes place | IM | once daily | until abortion | 🌎 NA |
| Abortifacient (From day 80-300) | 2.5 mg q12h | IM | q12h | approx 4 injections on average | 🌎 NA |
| Estrus synchronization (Two injection method) | 5 mg dinoprost IM on day 1 and again on day 16 | IM | day 1 and day 16 | 16 days | 🌎 NA |
소
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Estrus synchronization | 25 mg IM either once or twice at a 10-12 day interval | IM | once or twice | 10-12 day interval | 🌎 NA |
| Unobserved (silent) estrus | 25 mg IM | IM | once | once | 🌎 NA |
| Pyometra | 25 mg IM twice, 8 hours apart | IM | twice, 8 hours apart | 1 day | 🌎 NA |
| Abortifacient (5-150 days of gestation) | 25-30 mg IM | IM | once | once | 🌎 NA |
| Abortifacient (After 150 days of gestation) | 25 mg dexamethasone with 25 mg dinoprost | IM | once | once | 🌎 NA |
| Induce parturition | 25-30 mg IM | IM | once | once | 🌎 NA |
- Pyometra: Alternatively, 25 mg IM once (McCormack 1986).
- Abortifacient (5-150 days of gestation): Alternatively, 25 mg IM during first 100 days.
- Induce parturition: Delivery will occur in about 72 hours.
돼지
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Estrus synchronization (grouping) | 15 mg dinoprost IM, followed in 12 hours by 10 mg IM | IM | twice, 12 hours apart | 1 day | 🌎 NA |
| Abortifacient | 5-10 mg IM | IM | once | once | 🌎 NA |
| Induce parturition | 10-25 mg IM from 2-6 days before expected parturition | IM | once | once | 🌎 NA |
- Estrus synchronization (grouping): At 15-55 days of gestation.
- Abortifacient: Abortion occurs in 24-48 hours.
- Induce parturition: Farrowing usually occurs 24-36 hours later.
양
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Estrus synchronization | 8 mg IM on day 5 of estrous cycle and repeat in 11 days | IM | twice, 11 days apart | 11 days | 🌎 NA |
| Abortifacient (first two months of pregnancy) | 10-15 mg IM | IM | once | once | 🌎 NA |
- Abortifacient (first two months of pregnancy): Abortion takes place within 72 hours.
염소
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Estrus synchronization | 8 mg IM on day 4 of estrous cycle and repeat in 11 days | IM | twice, 11 days apart | 11 days | 🌎 NA |
| Pseudopregnancy (hydrometra/mucometra) | 5 mg IM once | IM | once | once | 🌎 NA |
| Abortifacient | 5-10 mg IM throughout entire pregnancy | IM | once | once | 🌎 NA |
| Induce parturition | 2.5-20 mg on days 144-149 | IM | once | once | 🌎 NA |
- Abortifacient: Abortion takes place in 4-5 days.
- Induce parturition: Higher dosage (20 mg) yields more predictable interval to delivery.
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
개요
디노프로스트 트로메타민은 천연 프로스타글란딘 F2알파(PGF2α)의 트로메타민 염으로, 여러 동물의 수의 번식 의학에서 널리 사용됩니다.
- 대동물: 주로 소, 말, 돼지 및 소형 반추동물의 발정 동기화, 둔성 발정 치료, 자궁축농증 치료를 위한 황체용해제 및 유산 유도제 또는 분만 유도제로 사용됩니다.
- 소동물: 개와 고양이에서 유산 유도제 및 개방형 자궁축농증의 보조적 내과 치료제로 허가 외(off-label) 사용됩니다.
임상 요점: 디노프로스트는 개에서 치료 지수가 매우 좁습니다. 반수치사량(LD50)이 권장 치료 용량의 약 5배에 불과하므로 정확한 투여와 세심한 모니터링이 필수적입니다. 자궁축농증에 대한 최신 프로토콜은 안전성 프로파일이 더 나은 아글레프리스톤과 클로프로스테놀 또는 미소프로스톨의 병용을 선호하는 추세입니다.
작용 기전
Dinoprost acts directly as a prostaglandin F2alpha (PGF2α) analog.
- Luteolysis: Binds to specific PGF2α receptors on the corpus luteum → inhibits steroidogenesis → induces structural and functional regression of the corpus luteum (luteolysis) → rapid decline in serum progesterone levels.
- Myometrial Contraction: Directly stimulates myometrial smooth muscle activity → increases intracellular calcium → induces strong uterine contractions.
- Cervical Relaxation: Promotes relaxation and dilation of the cervix, facilitating the expulsion of uterine contents (fetus or purulent material in pyometra).
안전성·주의사항
금기사항
- Pregnancy (unless abortion or induced parturition is desired)
- Intravenous (IV) administration
- Animals with bronchoconstrictive respiratory disease (e.g., asthma, 'heaves' in horses)
- Mares with acute or subacute disorders of the vascular system, GI tract, respiratory system, or reproductive tract
- Camelids (associated with acute toxicity and death)
- Relative contraindication: Closed-cervix pyometra
- Extreme caution in elderly (>8 years old) or debilitated animals, or those with severe cardiopulmonary, renal, or hepatic disease
부작용
- Dogs/Cats: Abdominal pain, emesis, defecation, urination, pupillary dilation followed by constriction, tachycardias, restlessness, anxiety, fever, hypersalivation, dyspnea, panting. Fatalities are possible (especially in dogs). Cats may exhibit intense grooming and vocalization.
- Cattle: Infection at injection site, salivation, hyperthermia (especially at higher doses).
- Swine: Erythema, pruritus, urination, defecation, slight ataxia, hyperpnea, dyspnea, nesting behavior, abdominal muscle spasms, tail movements, increased vocalization, salivation.
- Horses: Transient decreased body temperature, sweating. Less frequently: increased respiratory and heart rates, ataxia, abdominal pain, lying down.
주의
HUMAN SAFETY WARNING: Pregnant women, asthmatics, and women of childbearing age should handle this product with extreme caution. Accidental skin exposure should be washed off immediately with soap and water.
VETERINARY PRECAUTIONS:
- Do NOT administer intravenously (IV).
- Use with extreme caution in dogs and cats over 8 years of age or those with significant concurrent illness.
- Monitor small animals closely for severe cardiorespiratory effects after administration.
- Closed-cervix pyometra is considered a relative contraindication due to the risk of uterine rupture from induced contractions.
약물 상호작용
Activity may be enhanced by dinoprost.
Reduced effect of dinoprost would be expected with concomitant administration.
모니터링
- Cardiorespiratory effects (especially in dogs and cats, particularly after higher dosages)
- Adverse effects (vomiting, diarrhea, hyperthermia, distress)
- Efficacy of treatment (e.g., ultrasound for pyometra resolution or pregnancy termination, observation for estrus)
약동학
반감기
흡수
Distributes very rapidly to tissues after injection.
분포
Rapidly distributed to tissues.
과다투여
Dogs are highly sensitive to the toxic effects of dinoprost. The LD50 in the bitch is reported to be 5.13 mg/kg SC, which is only about 5 times greater than the recommended dose used by some clinicians.
In large animals (cattle, swine, horses), overdose quantities (e.g., 5-10X recommended doses) result in exaggerated adverse effects such as hyperthermia, vomiting, and severe abdominal cramping.
Treatment: If clinical signs are severe in any species, immediate supportive and symptomatic therapy is recommended.
제품
제형
- Injection: 5 mg/mL (as dinoprost) in 10 mL and 30 mL vials
동물용의약품
- Dinoprost Tromethamine for injection, equivalent to 5 mg/mL of dinoprost in 10 mL and 30 mL vials (Lutalyse Sterile Solution, Amtech Prostamate, In-Synch, Prostamate)
규제 현황
규제 데이터 없음: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
보관·안정성
Store at room temperature (15-30°C) in airtight containers. Dinoprost is considered to be relatively insensitive to heat, light, and alkalis.
보호자 정보
인체 안전에 대한 중대한 경고: 임산부, 천식 환자 또는 기관지 질환이 있는 사람은 이 제품을 다룰 때 극도로 주의해야 합니다. 피부에 우발적으로 노출된 경우 즉시 비누와 물로 씻어내야 합니다.
- 이 약물은 생식기 질환(예: 자궁 감염/자궁축농증)을 관리하거나 원치 않는 임신을 중절하는 데 사용됩니다.
- 개와 고양이의 경우, 주사 후 곧(보통 5~15분 이내) 부작용이 나타날 수 있습니다. 헐떡임, 침 흘림, 구토, 설사, 배뇨 및 불안감 등이 포함될 수 있습니다.
- 이러한 부작용을 지켜보는 것이 고통스러울 수 있지만, 일반적으로 20~30분 이내에 사라집니다. 이 시간 동안 반려동물을 편안하고 청소하기 쉬운 공간에 두십시오.
- 반려동물이 심각한 호흡 곤란, 극도의 무기력증을 보이거나 부작용이 지속되는 경우 즉시 수의사에게 연락하십시오.
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