디페녹실레이트

투여 경로

금기

• Toxigenic diarrhea
• Infectious enteritis (e.g., Salmonella, Parvovirus)
• Obstructive GI disease
• Severe liver disease
• Cats (generally avoided due to CNS excitation/depression)

이상반응

• Constipation
• Sedation
• Bloating
• Paralytic ileus
• CNS depression (especially in cats)
• Anticholinergic effects at high doses (dry mouth, tachycardia)

약물 상호작용

• Monoamine Oxidase Inhibitors (MAOIs) · May cause severe hypertensive crisis · major
• CNS Depressants (e.g., sedatives, anesthetics) · Additive CNS and respiratory depression · moderate
• Anticholinergics · Additive anticholinergic effects and increased risk of severe ileus · moderate

모니터링

• Fecal output and consistency
• Bowel sounds (auscultation for ileus)
• CNS status (sedation or excitation)

과용량

Overdose can lead to severe **CNS depression**, **respiratory depression**, and **paralytic ileus**. Due to the atropine component, anticholinergic signs (tachycardia, dry mucous membranes, mydriasis) may also occur. **Treatment:** Naloxone can be used to reverse the opioid effects. Provide supportive care for anticholinergic toxicity and respiratory depression.