λνλ Ήμ€λ μ΄νΈ
λνλ Ήμ€λ μ΄νΈλ μ£Όλ‘ **μ§μ¬μ **λ‘ μ¬μ©λλ ν©μ± **μ€νΌμ€μ΄λ μμ©μ **μ λλ€. λ¨μ©μ λ°©μ§νκΈ° μν΄ μΌλ°μ μΌλ‘ μΉλ£ μ©λ μ΄νμ **μνΈλ‘ν**κ³Ό νΌν©λμ΄ μ ννλ©λλ€. > **κ²½κ³ :** μμ₯κ΄ μ΄λμ κ°μμν€λ©΄ λ³μ체 λ° λ μμ λ°°μΆμ΄ μ§μ°λ μ μμΌλ―λ‘ κ°μΌμ± μ€μ¬λ λ μ μμ± κ°μΌμλ μ£Όμν΄μ μ¬μ©ν΄μΌ ν©λλ€. **μμ ν:** κ³Όκ±°μλ κΈμ± μ€μ¬μ μ¬μ©λμμΌλ, νλ μμνμμλ κ·Όλ³Έ μμΈμ ν΄κ²°νκ±°λ νλ‘λ°μ΄μ€ν±μ€λ₯Ό μ¬μ©νλ κ²μ μ νΈνλ©°, μ΄λ μ‘°μ μ λ νΉμ λμΉμ± μ¦λ‘μλ§ μ νμ μΌλ‘ μ¬μ©ν©λλ€.
μμ© κΈ°μ : Diphenoxylate acts locally and centrally on **mu-opioid receptors** in the gastrointestinal tract. * **Increases** intestinal segmental smooth muscle tone. * **Decreases** the propulsive activity (peristalsis) of smooth muscle. * **Decreases** electrolyte and water secretion into the intestinal lumen. β The addition of **atropine** is at a sub-therapeutic dose to cause unpleasant anticholinergic side effects if overdosed, thereby discouraging abuse.
ν¬μ¬ κ²½λ‘
κΈκΈ°
- Toxigenic diarrhea
- Infectious enteritis (e.g., Salmonella, Parvovirus)
- Obstructive GI disease
- Severe liver disease
- Cats (generally avoided due to CNS excitation/depression)
μ΄μλ°μ
- Constipation
- Sedation
- Bloating
- Paralytic ileus
- CNS depression (especially in cats)
- Anticholinergic effects at high doses (dry mouth, tachycardia)
μ½λ¬Ό μνΈμμ©
- Monoamine Oxidase Inhibitors (MAOIs) Β· May cause severe hypertensive crisis Β· major
- CNS Depressants (e.g., sedatives, anesthetics) Β· Additive CNS and respiratory depression Β· moderate
- Anticholinergics Β· Additive anticholinergic effects and increased risk of severe ileus Β· moderate
λͺ¨λν°λ§
- Fecal output and consistency
- Bowel sounds (auscultation for ileus)
- CNS status (sedation or excitation)
κ³Όμ©λ
Overdose can lead to severe **CNS depression**, **respiratory depression**, and **paralytic ileus**. Due to the atropine component, anticholinergic signs (tachycardia, dry mucous membranes, mydriasis) may also occur. **Treatment:** Naloxone can be used to reverse the opioid effects. Provide supportive care for anticholinergic toxicity and respiratory depression.
VetSheet μ½λ¬Ό λ νΌλ°μ€λ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μμ¬κ²°μ 보쑰 λꡬμ΄λ©°, μ λ¬Έμ νλ¨μ΄λ μ μ‘°μ¬μ μ΅μ λΌλ²¨μ λμ νμ§ μμ΅λλ€.