돔페리돈

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Known hypersensitivity to domperidone
• Presence or suspicion of gastrointestinal obstruction, perforation, or hemorrhage
• Pregnant mares >15 days prior to expected foaling date (unless specifically managed)
• Horses intended for human consumption
• Gastrointestinal hemorrhage
• Mechanical GI obstruction or perforation
• Prolactin-secreting pituitary tumors (prolactinomas)
• Known hypersensitivity to the drug

이상반응

• Galactorrhea (inappropriate milk production)
• Gynecomastia
• Premature lactation in horses (dripping milk prior to foaling)
• Failure of passive transfer in foals
• Rarely: somnolence or dystonic reactions
• Arrhythmias (associated with withdrawn injectable human products, especially with hypokalemia or heart disease)
• Galactorrhea (milk production in females)
• Mammary gland hyperplasia
• Changes in estrus cycle
• Mild gastrointestinal upset

약물 상호작용

• Azole Antifungals (e.g., ketoconazole) · May increase domperidone levels due to metabolic inhibition.
• Anticholinergic Drugs · May reduce the gastrointestinal prokinetic efficacy of domperidone.
• Bromocriptine / Cabergoline · Domperidone may antagonize their dopamine-agonist effects on prolactin.
• Macrolide Antibiotics (e.g., erythromycin, clarithromycin) · May increase domperidone levels.
• Opioids · May reduce the gastrointestinal prokinetic efficacy of domperidone. · moderate
• Sustained-Release or Enteric-Coated Oral Medications · Domperidone may alter the absorptive characteristics of these drugs by decreasing GI transit times.
• Antacids · May decrease the oral absorption of domperidone · minor
• H2-receptor antagonists (e.g., famotidine) · May decrease the oral absorption of domperidone due to altered gastric pH · minor
• Ketoconazole · Inhibits CYP3A4 metabolism of domperidone, potentially increasing plasma concentrations and risk of QT prolongation · major
• Erythromycin · Inhibits CYP3A4 metabolism of domperidone, increasing plasma concentrations. · major
• Anticholinergics (e.g., Atropine) · May antagonize the gastrokinetic effects of domperidone. · moderate
• Antacids and H2 Blockers (e.g., Famotidine, Omeprazole) · Increase gastric pH, which may decrease the oral absorption of domperidone. Administer at least 2 hours apart. · moderate

모니터링

• Clinical efficacy (resolution of vomiting, improved gastric emptying, or adequate milk production)
• Serum IgG concentrations in foals born to treated mares
• Serum prolactin levels (if indicated)
• Resolution of nausea and vomiting
• Improvement in clinical signs of Leishmaniasis (if used for this indication)
• Signs of galactorrhea, mammary enlargement, or false pregnancy in females

과용량

There is no specific antidote for a domperidone overdose. - Employ standard gastrointestinal decontamination procedures if ingestion is recent and the patient is asymptomatic. - Provide supportive and symptomatic care as needed. Monitor for potential neurological signs (especially in MDR1-mutant dogs) or gastrointestinal upset.