에드로포늄

투여 경로

금기

• Mechanical gastrointestinal obstruction
• Mechanical urinary tract obstruction
• Peritonitis

이상반응

• Nausea
• Vomiting
• Increased salivation
• Diarrhoea
• Muscle fasciculations
• Severe bradyarrhythmias
• Asystole

약물 상호작용

• Depolarizing neuromuscular relaxants (e.g., suxamethonium) · Potentiates neuromuscular blockade · major

모니터링

• Heart rate and rhythm (ECG recommended during administration)
• Respiratory rate and effort
• Muscle strength and tone
• Cholinergic signs (salivation, vomiting, defecation)

과용량

Overdosage may lead to **muscle fasciculations** and **paralysis**. Severe bradyarrhythmias, even asystole, may occur if edrophonium is used to antagonize neuromuscular block without the co-injection of atropine. > **Treatment:** Respiration should be supported and **atropine** administered IV to counteract muscarinic effects.