에프리노멕틴

항기생충제 - 아버멕틴계

에프리노멕틴(Eprinomectin)은 주로 소의 국소 도포용(Pour-on) 용액으로 사용되는 매우 효과적인 **아버멕틴계 항기생충제**입니다. 위장관 선충, 폐충, 소 가죽파리 유충, 이, 옴진드기, 뿔파리 등 다양한 내외부 기생충에 대해 광범위한 구충 효과를 제공합니다。 - **주요 장점**: 소에게 라벨 지시대로 사용할 경우, **우유나 고기에 대한 휴약 기간이 전혀 필요하지 않아** 낙농 및 육우 농가에 매우 편리합니다。 - **오프라벨 사용**: 말의 흡혈진드기(Psoroptic mange) 및 토끼의 귀진드기(*Psoroptes cuniculi*) 치료에도 효과가 있는 것으로 나타났습니다。 *임상 팁*: 대식환 락톤(macrocyclic lactone) 계열로서 이버멕틴과 유사한 안전성 프로파일을 공유하지만, 반추동물의 국소 흡수에 최적화되도록 특별히 제조되었습니다。

작용 기전: Eprinomectin exerts its antiparasitic effect by binding selectively to **glutamate-gated chloride ion channels** found in invertebrate nerve and muscle cells. - **Mechanism**: Binding → Increased cell membrane permeability to chloride ions → Hyperpolarization of the nerve/muscle cell → **Paralysis and death** of the parasite. - It also enhances the release of **gamma-aminobutyric acid (GABA)** at presynaptic neurons, which acts as an inhibitory neurotransmitter, blocking post-synaptic stimulation. - *Safety*: Mammals are generally unaffected because they lack glutamate-gated chloride channels, and macrocyclic lactones do not readily cross the mammalian blood-brain barrier (BBB) under normal conditions.

동물 종별 용량

Cats

Treatment and prevention of fleas, ticks, nematodes (including feline lungworm and Capillaria plica), and prevention of heartworm disease · Monthly application · topical · monthly · 1 month per application · Apply appropriate pipette size based on cat's body weight.

Horses

Treatment of psoroptic (P. equi) mange · 500 micrograms/kg (0.5 mg/kg) topically once weekly for 4 treatments · topical · once weekly · 4 treatments · Author's suggest getting informed consent before use.

SmallMammals

Ear mites (Psoroptes cuniculi) in rabbits · 5 mg/kg topically, twice at 14 day intervals · topical · twice at 14 day intervals · 2 treatments · One small study (6 subjects) showed partial response.

Cattle

Labeled indications (gastrointestinal roundworms, cattle grubs, lice, mange mites, horn flies, lungworms) · 1 mL per 10 kg (22 lb) body weight applied topically along backline in a narrow strip from the withers to the tailhead · topical · once

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

topicalTopical

금기

Oral administration
Intravenous administration
Cats weighing < 0.6 kg
Kittens < 7 weeks of age
Dogs (not intended for use)

이상반응

Ineffectiveness for parasite control (reported in FDA database)
Anorexia
Udder hypogalactia
Mild clumping of the hair at the application site

약물 상호작용

ciclosporin · Potential interaction as both are P-glycoprotein substrates; none reported clinically · minor
itraconazole · Potential interaction as both are P-glycoprotein substrates; none reported clinically · minor
loperamide · Potential interaction as both are P-glycoprotein substrates; none reported clinically · minor
steroids · Potential interaction as both are P-glycoprotein substrates; none reported clinically · minor
opiates · Potential interaction as both are P-glycoprotein substrates; none reported clinically · minor
P-glycoprotein substrates (e.g., ciclosporin, itraconazole, loperamide, steroids, opiates) · Theoretical potential for interaction due to shared P-glycoprotein efflux pump mechanisms, though none have been clinically reported. · minor

모니터링

Clinical efficacy (parasite clearance)
Adverse reactions (anorexia, milk production in dairy cattle)
Efficacy of parasite control
Application site reactions (hair clumping, alopecia, erythema)

과용량

Calves given up to 5X dosage showed no signs of adverse effects. One subject (of 6) showed signs of mydriasis when given a 10X dose.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.