에스트라디올 시피오네이트

호르몬제 (에스트로겐)

에스트라디올 시피오네이트는 지속형 천연 에스트로겐 에스테르 유도체입니다. 과거에는 소동물의 낙태약(교미 후 피임)으로 널리 사용되었으나, **치명적인 골수 억제**(재생불량성 빈혈) 및 **자궁축농증**을 유발할 위험이 높아 현재 대부분의 수의 번식학자들은 개와 고양이에게 사용을 권장하지 않습니다. 더 안전하고 효과적인 대안이 선호됩니다. > **임상 주의사항**: FDA는 이 약물을 식용 동물에 사용하는 것을 엄격히 금지하고 있으며, 해당 동물을 위한 투여나 조제는 불법입니다.

작용 기전: Estradiol is the most active endogenous estrogen. It diffuses across the cell membrane and binds to specific intracellular **estrogen receptors (ERα and ERβ)**. The receptor-hormone complex translocates to the nucleus → binds to **estrogen response elements (EREs)** on DNA → modulates gene transcription. **Key systemic effects include:** * **Reproductive:** Stimulates normal growth and development of female sex organs, increases cervical mucosal secretions, thickens vaginal mucosa, and induces endometrial proliferation and uterine tone. * **Skeletal:** Increases calcium deposition, accelerates epiphyseal closure, and promotes bone formation. * **Endocrine:** Modulates pituitary gonadotropin release, which can inhibit lactation, ovulation, and androgen secretion.

동물 종별 용량

Cats

Pregnancy avoidance after mismating · 250 micrograms/kg (0.25 mg/kg) IM once 6 days after coitus; or 0.25 mg/cat IM at 40 hours after coitus · IM · once · Rarely used for this indication today as there are safer, more effective treatments.

Cattle

Any · Illegal · The FDA has stated that the use of ECP in food-producing animals is illegal.

Horses

To enhance estrus behavior and receptivity in ovariectomized mares · 5-10 mg (total dose) IM once · IM · once
Treatment of mares with estrogen-responsive incontinence · 4-10 micrograms/kg estradiol cypionate IM daily for three days and then every other day · IM · daily then q48h · 3 days then ongoing · Some mares will improve, but does not 'cure'.

Dogs

Pregnancy avoidance after mismating · 44 micrograms/kg (0.044 mg/kg) IM once; during day 4 estrus to day 2 of diestrus · IM · once · Rarely used for this indication today as there are safer, more effective treatments. Toxic at >=100 micrograms/kg.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

IMPOImplants

금기

Pregnancy (teratogenic and causes fetal bone marrow depression)
Food-producing animals (illegal per FDA)
Ferrets (highly susceptible to severe bone marrow toxicity)
Estrogen-responsive incontinence in small animals (safer alternatives like DES or estriol should be used)

이상반응

Bone marrow toxicity (thrombocytopenia, leukopenia, fatal aplastic anemia)
Cystic endometrial hyperplasia
Pyometra
Mammary neoplasia
Feminization (in males)
Prolonged estrus (in females)
Genital irritation (cattle)
Decreased milk flow (cattle)
Follicular cysts (cattle)

약물 상호작용

Azole Antifungals (fluconazole, itraconazole, ketoconazole) · May increase estrogen levels due to CYP450 enzyme inhibition.
Corticosteroids · Enhanced glucocorticoid effects; estrogens may alter protein binding or decrease metabolism of corticosteroids.
Macrolide Antibiotics (erythromycin, clarithromycin) · May increase estrogen levels.
Phenobarbital · May decrease estrogen activity via hepatic enzyme induction.
Rifampin · May decrease estrogen activity via hepatic enzyme induction.
St. John's Wort · May decrease estrogen activity.
Warfarin · Oral anticoagulant activity may be decreased; dosage adjustments may be necessary.

모니터링

Packed Cell Volumes (PCV)
White blood cell counts (CBC)
Platelet counts (Baseline, one month after therapy, and repeated two months after cessation if abnormal)
Liver function tests

과용량

Acute overdosage reports in veterinary patients are rare, but chronic or high-dose exposure leads to severe adverse effects. **Overdose manifestations:** * **Small Animals:** Severe bone marrow depression (thrombocytopenia, leukopenia, aplastic anemia), cystic endometrial hyperplasia, and pyometra. * **Cattle:** Prolonged estrus, genital irritation, decreased milk flow, precocious development, and follicular cysts. Treatment is largely supportive. If bone marrow suppression occurs, aggressive supportive care (transfusions, broad-spectrum antibiotics) is required, though prognosis for aplastic anemia is poor.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.