에토돌락
Etodolac
Indole acetic acid derivative
다른 이름: EtoGesic · Lodine · AY-24236 · etodolacum · etodolic acid · Acudor · Articulan · Dualgan · Eccoxolac · Edolan · Elderin · Etonox · Etopan · Flancox · Hypen · Lodot · Lonine · Metazin · Sodolac · Ultradol · Zedolac
VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
동물 종별 용량
🌎 NA — North America🌍 EU — Europe
개
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Treatment of pain and inflammation associated with osteoarthritis | 10-15 mg/kg | PO | once daily | — | 🌎 NA |
| Treatment of pain and inflammation associated with osteoarthritis | 10-15 mg/kg | SC | once | — | 🌎 NA |
- Treatment of pain and inflammation associated with osteoarthritis: Dogs less than 5 kg cannot be accurately dosed with EtoGesic tablets. Adjust dose to obtain satisfactory response, but do not exceed 15 mg/kg. For long-term therapy, reduce dose level to minimum effective dosage.
- Treatment of pain and inflammation associated with osteoarthritis: Administer as a dorsoscapular subcutaneous injection. If needed, daily doses of tablets may begin 24 hours after the last injectable treatment. Use alternate injection sites.
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
개요
에토돌락(Etodolac)은 주로 반려견의 골관절염과 관련된 통증 및 염증 관리에 수의학에서 사용되는 비스테로이드성 항염증제(NSAID)입니다.
- 경구용 정제 및 주사제 형태로 제공됩니다.
- 개에서 비교적 긴 반감기를 가져 편리한 1일 1회 투여가 가능합니다.
- 임상 요점: 효과적이긴 하지만 일부 최신 수의용 NSAID에 비해 치료 지수가 좁기 때문에 위장관 독성을 피하려면 정확한 용량 투여가 매우 중요합니다. 치료 용량의 2.7배만 투여해도 위장관 병변이 발생할 수 있습니다.
작용 기전
Etodolac exerts its analgesic, anti-inflammatory, and antipyretic effects primarily by inhibiting the cyclooxygenase (COX) enzymes.
- Arachidonic Acid → Prostaglandins: By blocking COX, etodolac prevents the conversion of arachidonic acid into pro-inflammatory prostaglandins.
- It is generally considered a COX-1 sparing drug rather than highly COX-2 selective in dogs. In horses, it does not exhibit much COX-2 selectivity.
- Additionally, etodolac inhibits macrophage chemotaxis, which further blunts the inflammatory cascade at the site of tissue injury.
안전성·주의사항
금기사항
- Known hypersensitivity to etodolac
- Dogs less than 12 months of age
- Breeding, pregnant, or lactating dogs (safe use not established)
- Cats (highly sensitive to toxicity)
부작용
- Vomiting
- Regurgitation
- Diarrhea
- Lethargy
- Hypoproteinemia
- Urticaria
- Behavioral changes
- Inappetence
- Hepatotoxicity (rare)
- Nephrotoxicity (rare)
- Localized pain or tissue reactions at injection site
- Decreased total serum T4
- Keratoconjunctivitis sicca (KCS)
주의
Use with caution in dogs with preexisting or occult GI, hepatic, renal, cardiovascular, or hematologic abnormalities as NSAIDs may exacerbate these conditions.
Important: Patients may be more susceptible to renal injury from etodolac if they are dehydrated, on diuretics, or have preexisting renal, hepatic, or cardiovascular dysfunction.
Terminate therapy if inappetence, vomiting, fecal abnormalities, or anemia are observed.
약물 상호작용
May reduce antihypertensive effects and increase the risk for renal injury.
May decrease etodolac plasma levels and increase likelihood of GI adverse effects (blood loss). Concomitant use is not recommended.
May increase cyclosporine blood levels and increase the risk for nephrotoxicity.
May increase serum levels of digoxin. Use with caution in severe cardiac failure.
May reduce the saluretic and diuretic effects of furosemide.
Serious toxicity has occurred with concomitant NSAID use.
Potential for increased risk of nephrotoxicity.
May increase the metabolism of etodolac in dogs.
May cause a significant increase in serum levels and half-life of etodolac.
May increase the risk for bleeding.
모니터링
- Baseline physical exam, CBC, Serum chemistry panel (liver and renal function), and Urinalysis
- Reassess liver enzymes at one week of therapy
- Tear production (Schirmer Tear Test) prior to and during therapy due to KCS risk
- Clinical efficacy (pain scoring)
- Signs of adverse reactions: inappetence, vomiting, melena, diarrhea, PU/PD, jaundice, lethargy
약동학
반감기
흡수
Rapidly and nearly completely absorbed after oral administration. Food may alter the rate, but not the extent, of absorption. Peak serum levels occur about 2 hours post dosing. Oral bioavailability in horses is about 77%.
분포
Highly bound to serum proteins. In horses, volume of distribution is 0.29 L/kg.
대사
Glucuronide conjugates have been detected in the bile but not the urine.
배설
Primarily excreted via the bile into the feces. Rate of enterohepatic circulation may be affected by the presence of food in the gut.
과다투여
Etodolac has a relatively narrow therapeutic window in dogs.
- 2.7X overdose (40 mg/kg/day): Can cause GI ulcers, weight loss, emesis, and local occult blood.
- 5.3X overdose (80 mg/kg/day): Highly lethal; caused death or moribund state secondary to severe GI ulceration in safety studies.
- Feline Toxicity: Cats are highly sensitive. Exposures have resulted in acute renal failure, anorexia, collapse, hyperkalemia, and hypersalivation.
Treatment: Decontamination with emetics and/or activated charcoal may be appropriate for acute ingestions. Use gastrointestinal protectants for expected GI effects. If renal effects are anticipated, aggressive fluid diuresis is warranted.
제품
제형
- Oral tablets
- Subcutaneous injection
동물용의약품
- Etodolac Scored Tablets: 150 mg & 300 mg (EtoGesic)
- Etodolac Injection 10% (100 mg/mL) in 50 mL vials (EtoGesic Injectable)
인용의약품
- Etodolac Tablets: 400 mg & 500 mg
- Etodolac Capsules: 200 mg & 300 mg
- Etodolac Extended-release tablets: 400 mg, 500 mg & 600 mg
규제 현황
규제 데이터 없음: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
보관·안정성
Veterinary tablets should be stored at controlled room temperature (15-30°C). Injection should be stored at or below 77°F (25°C).
보호자 정보
투여 방법: 수의사가 처방한 대로 정확히 투여하십시오. 위장 장애의 가능성을 줄이기 위해 음식과 함께 먹이는 것이 좋습니다.
부작용 주의: 반려견에게 다음과 같은 증상이 나타나면 즉시 투여를 중단하고 수의사에게 연락하십시오.
- 구토 또는 역류
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- 식욕 부진 또는 극심한 무기력증
- 갈증 또는 배뇨 증가
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경고: 고양이나 다른 반려동물에게는 절대 이 약을 주지 마십시오. 매우 치명적인 독성을 띨 수 있습니다. 모든 동물과 어린이의 손이 닿지 않는 곳에 보관하십시오.
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