파모티딘

동물 종별 용량

투여 경로

금기

• Known hypersensitivity to H2 blockers
• Known hypersensitivity to famotidine or other H2 receptor antagonists

이상반응

• Bradycardia (if infused too rapidly IV)
• GI effects (anorexia, vomiting, diarrhea)
• Headache
• Dry mouth or skin
• Intravascular hemolysis (rare, anecdotally reported in cats given IV)
• Transient increase in serum gastrin (returns to baseline by 14 days)
• Generally has a very good safety profile with fewer side effects than cimetidine

약물 상호작용

• Azole Antifungals (ketoconazole, itraconazole, fluconazole) · Famotidine raises gastric pH, which may decrease the absorption of these agents. Administer the azole one hour prior to famotidine.
• Cefpodoxime, Cefuroxime · Famotidine may decrease the absorption of these cephalosporins. Taking with food may alleviate this effect.
• Iron Salts (Oral) · Famotidine may decrease the absorption of oral iron. Administer iron at least one hour prior to famotidine.

모니터링

• Clinical efficacy (decrease in symptomatology, endoscopic examination, resolution of blood in feces)
• Adverse effects
• Clinical signs of GI ulceration or bleeding (vomiting, melena, anorexia)
• Gastric pH (if clinically indicated and feasible)

과용량

Famotidine has a wide margin of safety. The minimum acute lethal dose in dogs is reported to be >2 grams/kg for oral doses and approximately 300 mg/kg for intravenous doses. IV doses in dogs ranging from 5-200 mg/kg caused vomiting, restlessness, mucous membrane pallor, and redness of the mouth and ears. Higher doses caused hypotension, tachycardia, and collapse. Most overdoses require only monitoring. In massive oral overdoses, gut-emptying protocols should be considered and supportive therapy initiated when warranted.