펜벤다졸
Fenbendazole
Methyl [5-(phenylthio)-1H-benzimidazol-2-yl]carbamate
다른 이름: Panacur · Safe-Guard · Granofen · Wormazole · Hoe-881V · Fenbendazolum
VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료
감사 완료 v13 용량 근거
구조화 용량 계산 근거Encephalitozoon cuniculi infection after diagnostic risk-benefit discussion
- q24h · 30d
반드시 함께 고려할 임상 맥락 (9)
- Infections marked by ocular, CNS, and renal disease
- Otitis interna and/or media
- Most common cause of vestibular signs must exclude first
- CNS infections (toxoplasmosis, abscess), neoplasia, trauma
- Many North American and European rabbits will be positive, indicative of prior (in utero) exposure and not necessarily active disease
- Definitive diagnosis based on organism (obligate intracellular microsporidian parasite) identification in affected tissues, generally postmortem
- Head CT/MRI is considered for excluding bulla disease, abscess, neoplasia
- Positive serology and response to treatment supports presumed diagnosis, but risk/benefit discussion required prior to initiation
- Risk of bone marrow suppression/aplastic anemia/pancytopenia with therapy must be considered/discussed prior to therapy
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
개요
펜벤다졸은 다양한 동물 종에 걸쳐 수의학에서 널리 사용되는 매우 효과적이고 광범위한 벤즈이미다졸계 구충제입니다.
주요 임상 특징:
- 선충류 효능: 위장관 회충, 구충, 편충에 매우 효과적입니다.
- 조충류 효능: 조충(Taenia) 종에는 효과적이나, 흔한 벼룩 조충(개조충)에는 효과가 없습니다.
- 원충류 효능: 개와 고양이의 지알디아(Giardia) 감염에 대한 1차 치료제로 간주됩니다.
- 호흡기 기생충: 다양한 폐충 감염(예: 고양이폐충, 모세선충, 폐흡충) 치료에 자주 사용됩니다.
임상 요점: 펜벤다졸은 안전역이 매우 넓어 임신 중인 동물의 기생충(지알디아 포함) 감염을 치료하는 데 가장 우선적으로 선택되는 약물입니다.
작용 기전
Fenbendazole is a time-dependent antiparasitic agent, which is why multi-day dosing is typically required in small animals.
- Primary Mechanism: It selectively binds to parasite β-tubulin → prevents tubulin polymerization → inhibits microtubule formation. This disrupts essential intracellular transport mechanisms within the parasite.
- Secondary Mechanism: At higher concentrations, it disrupts metabolic pathways by inhibiting key enzymes such as fumarate reductase and malate dehydrogenase → depletes ATP/energy reserves → parasite death.
안전성·주의사항
금기사항
- Not FDA-approved for use in horses intended for food purposes
부작용
- Hypersensitivity reactions (secondary to antigen release by dying parasites)
- Salivation (infrequent)
- Vomiting (infrequent)
- Diarrhea (infrequent)
- Pancytopenia (rarely reported in dogs)
- Bone marrow hypoplasia (rarely reported in dogs)
주의
Important: Single doses are generally not effective in dogs and cats; treatment must continue for at least 3 consecutive days.
- Hypersensitivity: Reactions may occur secondary to antigen release by dying parasites, particularly in animals with high parasite burdens.
- Food Animal Withdrawal: Observe appropriate slaughter withdrawal times for cattle and swine based on the specific product used.
약물 상호작용
Abortions in cattle and death in sheep have been reported after concurrent use
모니터링
- Fecal examinations to confirm parasite clearance
- Monitor for hypersensitivity reactions if treating heavy parasite burdens
- Fecal examination for parasite clearance
- Complete blood count (CBC) if bone marrow hypoplasia is suspected
약동학
흡수
Marginally absorbed after oral administration. The amount absorbed from the gut is associated with the solubility of the drug, not the dose given. Bioavailability is significantly increased in dogs when administered with food (fat content does not alter this).
분포
Reaches systemic circulation sufficiently to treat migrating larvae and lungworms, though specific distribution parameters are not detailed.
대사
Absorbed fenbendazole is metabolized to the active compound oxfendazole (sulfoxide) and the sulfone.
배설
In sheep, cattle, and pigs, 44-50% of a dose is excreted unchanged in the feces, and <1% in the urine.
과다투여
Fenbendazole is exceptionally well tolerated, even at doses up to 100X the recommended dose.
- The LD50 in laboratory animals exceeds 10 grams/kg when administered orally.
- It is highly unlikely that an acute overdosage would lead to any significant clinical signs.
제품
제형
- Granules (22.2%)
- Paste (10%)
- Type B Medicated Feed (1.8%, 0.96%)
- Type C Medicated Feed (0.50%, 35% Salt Free-choice)
- Pellets (0.5%, 1.96%)
- Premix 20% Type A
- Chewable Tablets (Combination with Ivermectin and Praziquantel)
- 222 mg/g oral granules (22%)
- 440 mg/g oral granules (44%)
- 880 mg/g oral granules (88%)
- 25 mg/ml oral suspension (2.5%)
- 100 mg/ml oral suspension (10%)
- 187.5 mg/g oral paste (18.75%)
동물용의약품
- Fenbendazole Granules: 222 mg/gram (22.2%)
- Fenbendazole Suspension: 100 mg/mL (10%)
- Fenbendazole Paste: 100 mg/gram (10%)
- Fenbendazole Type B Medicated Feed (1.8%, 0.96%)
- Fenbendazole Type C Medicated Feed (0.50%, 35% Salt Free-choice)
- Fenbendazole Pellets (0.5%, 1.96%)
- Fenbendazole Premix 20% Type A (200 mg/gram)
- Combination Products: Fenbendazole/Ivermectin/Praziquantel Chewable Tablets (Panacur Plus Soft Chews)
- Granofen
- Wormazole
규제 현황
Authorized proprietary products available.
Available as AVM-GSL (General Sales List) and NFA-VPS (Non-Food Animal - Veterinarian, Pharmacist, SQP).
규제 데이터 없음: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
보관·안정성
Fenbendazole products should be stored at room temperature.
보호자 정보
중요: 반려견에게 이 약을 투여할 때는 흡수율과 효과를 크게 높이기 위해 반드시 음식과 함께 먹이십시오.
- 다일 투여: 1회 투여로 끝나는 일부 구충제와 달리, 펜벤다졸은 효과를 보기 위해 보통 3~5일 연속 투여가 필요합니다. 복용을 건너뛰지 마십시오.
- 안전성: 매우 안전한 약물이지만, 간혹 가벼운 구토, 침 흘림 또는 설사를 경험할 수 있습니다.
- 예상되는 증상: 치료 후 반려동물의 대변에서 죽은 기생충이 보일 수 있으며, 이는 정상적인 현상입니다.
- 지알디아 치료: 지알디아 치료를 목적으로 하는 경우, 재감염을 막기 위해 반려동물을 목욕시키고(특히 엉덩이 부위) 주변 환경을 철저히 청소해 주십시오.
VetSheet 의약품 참고자료는 수의사 전문가의 임상 의사결정 지원을 위한 것이며, 전문적 판단이나 제조사의 최신 약물 정보를 대체할 수 없습니다.