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황산제일철

Ferrous Sulfate

Iron (II) sulfate

영양 보충제 / 조혈제PO개고양이말소돼지양

다른 이름: Fer-In-Sol · Feosol · FeroSul · Fer-Gen-Sol · eisen(II)-sulfat · ferreux (sulfate) · ferrosi sulfas heptahydricus · ferrous sulphate · ferrum sulfuricum oxydulatum · iron (II) sulphate heptahydrate · iron sulphate · ferrous sulfate, exsiccated · dried ferrous sulfate

VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료

100-300 mg (total dose) PO once a dayPO· q24h
100–300 mg — 개체당 고정 용량(체중에 따라 환산하지 않음)

용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.

동물 종별 용량

🌎 NA — North America🌍 EU — Europe

개

적응증용량경로빈도기간지역
Iron deficiency anemia100-300 mg (total dose) PO once a dayPOq24h—🌎 NA
Iron deficiency anemia100-300 mg per day (total dose) POPOq24h—🌎 NA
Adjunct to epoetin (erythropoietin) therapy100-300 mg (total dose) PO per dayPOq24h—🌎 NA
  • Iron deficiency anemia: Dose is for ferrous sulfate, not elemental iron.
  • Iron deficiency anemia: First correct underlying cause of blood loss. Absorption is enhanced if administered 1 hour before or several hours after feeding. Reduce dosage if GI side effects occur.

고양이

적응증용량경로빈도기간지역
Iron deficiency anemia50-100 mg (total dose) PO once dailyPOq24h—🌎 NA
Iron deficiency anemia30-200 mg (total dose) PO per dayPOq24h2 weeks or more🌎 NA
Adjunct to epoetin (erythropoietin) therapy50-100 mg (total dose) PO per dayPOq24h—🌎 NA
Adjunct to epoetin (erythropoietin) therapy5-50 mg per cat PO once dailyPOq24h—🌎 NA
Adjunct to epoetin (erythropoietin) therapy50-100 mg per cat PO once dailyPOq24h—🌎 NA
Adjunct to epoetin (erythropoietin) therapy10 mg/kg PO once dailyPOq24h—🌎 NA
  • Adjunct to epoetin (erythropoietin) therapy: Many cats do not tolerate oral iron therapy and are better treated with iron dextran at 50 mg IM q3-4 weeks.

말

적응증용량경로빈도기간지역
Hematinic2-8 g PO per dayPOq24h2 weeks or more🌎 NA

소

적응증용량경로빈도기간지역
Hematinic8-15 g PO per dayPOq24h2 weeks or more🌎 NA

돼지

적응증용량경로빈도기간지역
Hematinic0.5-2 g PO per dayPOq24h2 weeks or more🌎 NA

양

적응증용량경로빈도기간지역
Hematinic0.5-2 g PO per dayPOq24h2 weeks or more🌎 NA

용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.

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개요

황산제일철은 수의학에서 주로 ​철 결핍성 빈혈​(심각한 벼룩/구충 감염 또는 위장관 출혈과 같은 만성 출혈에 이차적으로 발생)을 치료하고, 만성 신장 질환으로 ​에리스로포이에틴(에포에틴)​ 치료를 받는 환자의 보조 요법으로 사용되는 경구용 철분 보충제입니다.

​임상 요점:​ 경구용 철분의 용량 계산은 혼동하기 쉽습니다. ​철염​(황산제일철)의 용량과 ​원소 철​의 용량을 구별하는 것이 중요합니다. 일반 황산제일철에는 약 20%의 원소 철(그램당 200mg의 원소 철)이 포함되어 있는 반면, 건조 황산제일철에는 약 30%의 원소 철(그램당 300mg의 원소 철)이 포함되어 있습니다.

작용 기전

Iron is an essential trace mineral required for the transport and utilization of oxygen.

Dietary or supplemental iron is absorbed primarily in the duodenum and proximal jejunum → binds to the transport protein transferrin in the plasma → transported to the bone marrow → incorporated into porphyrin to form heme.

Heme is a critical component of hemoglobin (in red blood cells) and myoglobin (in muscle). Ionized iron also acts as an essential cofactor for several metabolic enzymes, including cytochrome oxidase, succinic dehydrogenase, and xanthine oxidase. While iron does not directly stimulate erythropoiesis, it provides the necessary building blocks to correct hemoglobin deficits caused by iron deficiency.

안전성·주의사항

금기사항

  • Hemosiderosis
  • Hemochromatosis
  • Hemolytic anemias
  • Known hypersensitivity to iron products
  • Gastrointestinal ulcerative diseases (relative contraindication due to GI irritation)

부작용

  • Mild gastrointestinal upset (nausea, vomiting)
  • Black or dark-colored feces (normal and harmless)
  • Constipation or diarrhea

주의

​WARNING:​ Dosing of oral iron products can be confusing. Always verify whether the dose is for the iron salt (e.g., ferrous sulfate) or elemental iron. Use with caution in patients with GI ulcerative diseases due to the irritating properties of the drug. Large doses can color feces black, causing false-positives on guaiac tests for occult blood.

약물 상호작용

Antacids

May bind to iron and decrease oral absorption; administer at least two hours apart.

Calcium (Oral)

May bind to iron and decrease oral absorption; administer at least two hours apart.

Chloramphenicol

May delay the response to iron administration; avoid using in patients with iron deficiency anemia.

Fluoroquinolones (e.g., enrofloxacin)

Iron may significantly reduce the absorption of oral fluoroquinolones; administer at least two hours apart.

H2-Receptor Antagonists (e.g., famotidine)

Increased gastric pH may decrease iron absorption.

Penicillamine

Iron can decrease the efficacy of penicillamine by decreasing its absorption; space doses as far apart as possible.

Proton-Pump Inhibitors (e.g., omeprazole)

Increased gastric pH may decrease iron absorption.

Tetracyclines

Oral iron preparations can bind to orally administered tetracyclines, decreasing the absorption of both compounds.

Thyroxine

Iron may reduce the absorption of oral thyroxine; administer at least two hours apart.

Vitamin C (Ascorbic Acid)

May enhance the gastrointestinal absorption of iron.

모니터링

  • Clinical efficacy (resolution of anemia signs)
  • Hemograms (CBC)
  • Serum iron (Normal: Dogs 80-180 mcg/dL, Cats 70-140 mcg/dL)
  • Total iron binding capacity (TIBC) (Normal: Dogs 280-340 mcg/dL, Cats 270-400 mcg/dL)
  • Serum transferrin saturation

약동학

흡수

Complex and determined by diet, iron stores, erythropoiesis degree, and dose. Absorbed throughout the GI tract, but mostly in the duodenum and proximal jejunum. Food in the GI tract may reduce the amount absorbed.

분포

After absorption, ferrous iron is immediately bound to transferrin and transported to the bone marrow.

대사

Incorporated into hemoglobin. Iron metabolism occurs in a nearly closed system; iron liberated by hemoglobin destruction is reused by the body.

배설

Only small amounts are lost via hair and nail growth, normal skin desquamation, and GI tract sloughing.

과다투여

Ingestion of iron-containing products can result in life-threatening toxicity. As little as 400 mg of elemental iron can be fatal in a child.

​Clinical Signs of Toxicity:​

  • ​Phase 1 (30 mins to several hours):​ Acute gastrointestinal irritation, distress, vomiting (possibly hemorrhagic), abdominal pain, and diarrhea.
  • ​Phase 2 (12-48 hours):​ The patient may appear asymptomatic, but this can be a deceptive latent phase.
  • ​Phase 3:​ Peripheral vascular collapse, hypotension, cyanosis, pulmonary edema, fulminant hepatic failure, coma, and death.
  • ​Long-term Sequelae:​ Animals that survive may exhibit gastric scarring, strictures, and persistent digestive disturbances.

​Treatment:​

  • Must be handled as an absolute emergency.
  • ​Decontamination:​ Empty the stomach using gastric lavage with a large bore tube (avoid emetics if hemorrhagic vomiting is already present). Lavage with tepid water or 1-5% sodium bicarbonate solution.
  • Oral milk of magnesia may help bind the drug in the GI tract.
  • ​Antidote:​ Deferoxamine is a specific chelating agent used to bind absorbed iron.
  • ​Supportive Care:​ IV fluids for shock, treatment of acidosis, prophylactic antibiotics, oxygen, and management of coagulation abnormalities or seizures.

제품

제형

  • Oral Tablets
  • Oral Elixir/Liquid
  • Oral Drops

동물용의약품

  • No single-ingredient veterinary-FDA-approved products are available. Many multivitamin products containing iron are available.

인용의약품

  • Ferrous Sulfate Oral Tablets: 325 mg (65 mg iron)
  • Ferrous Sulfate Oral Elixir/Liquid: 220 mg/5mL (44 mg iron/5 mL), 300 mg/5 mL (60 mg iron/5 mL)
  • Ferrous Sulfate Oral Drops: 15 mg iron/mL, 75 mg/0.6 mL (15 mg iron/0.6 mL)

규제 현황

규제 데이터 없음: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

보관·안정성

Store in tight, light-resistant containers. If exposed to moisture or moist air, the drug is rapidly oxidized to a brownish-yellow ferric compound that should not be used medicinally. Exposure to light or an alkaline medium enhances this conversion.

보호자 정보

​위험:​ 철분 과다 복용은 독성이 매우 강하며 치명적일 수 있습니다. 모든 철분 보충제는 반려동물과 어린이의 손이 닿지 않는 곳에 엄격히 보관하십시오.

  • ​목적:​ 만성 출혈(예: 심각한 벼룩 또는 구충 감염, 출혈성 궤양)로 인해 자주 발생하는 철 결핍성 빈혈을 치료하거나 신장 질환이 있는 반려동물의 적혈구 생성을 돕기 위해 사용됩니다.
  • ​투여 방법:​ 공복(식사 1시간 전 또는 식사 몇 시간 후)에 흡수가 가장 잘 됩니다. 그러나 위장 장애나 구토를 유발하는 경우 소량의 음식과 함께 투여할 수 있습니다.
  • ​부작용:​ 반려동물의 대변이 검게 변하더라도 놀라지 마십시오. 이는 흡수되지 않은 철분이 소화관을 통과할 때 나타나는 정상적이고 무해한 부작용입니다.
  • ​상호작용:​ 제산제, 유제품 또는 특정 항생제(테트라사이클린 또는 플루오로퀴놀론 등)와 동시에 투여하지 마십시오. 최소 2시간 이상의 간격을 두고 투여하십시오.

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