플루닉신 메글루민

동물 종별 용량

투여 경로

금기

• Known hypersensitivity to flunixin
• Cats (generally contraindicated due to availability of safer alternatives)
• Patients with preexisting GI ulcers (e.g., Equine Gastric Ulcer Syndrome - EGUS)
• Patients with significant renal, hepatic, or hematologic diseases
• Breeding bulls (lack of reproductive safety data)
• Use to ambulate cattle intended for slaughter

이상반응

• Anaphylaxis (especially after rapid IV administration in horses and cattle)
• IM injection site reactions (localized swelling, induration, stiffness, sweating, and rarely clostridial myonecrosis)
• Gastrointestinal ulceration (oral and gastric ulcers, especially with prolonged use or high doses)
• Renal ischemia and nephrotoxicity (especially in dehydrated patients, dogs, and birds)
• Hematochezia and hematuria (reported in cattle treated > 3 days)
• Hypoproteinemia and hematologic abnormalities

약물 상호작용

• Aspirin · May decrease plasma levels of flunixin and increase the likelihood of GI adverse effects (blood loss)
• Cyclosporine · May increase cyclosporine blood levels and increase the risk for nephrotoxicity
• Digoxin · May increase serum levels of digoxin; use with caution in severe cardiac failure
• Enrofloxacin · Increases AUC and elimination half-life of both flunixin and enrofloxacin in dogs
• Furosemide & other diuretics · May reduce the saluretic and diuretic effects of the diuretic
• Methotrexate · Serious toxicity has occurred with concomitant use; use together with extreme caution
• Nephrotoxic agents (e.g., aminoglycosides, amphotericin B) · Increased risk of synergistic nephrotoxicity
• Probenecid · May cause a significant increase in serum levels and half-life of flunixin
• Warfarin · May increase the risk for bleeding

모니터링

• Analgesic, anti-inflammatory, and antipyretic efficacy
• Gastrointestinal effects (especially in dogs and horses)
• CBCs and occult blood in feces with chronic use in horses
• Renal parameters (BUN, Creatinine, USG) in susceptible species or dehydrated patients

과용량

Acute overdosage should be handled by using established protocols of emptying the gut (if oral ingestion and practical/possible) and treating the patient supportively. * **Gastric Ulceration**: A distinct possibility in horses that have received overdoses. Consider using prophylactic anti-ulcer medications (e.g., omeprazole) in overdosed horses. * **Renal Protection**: Ensure adequate hydration and monitor renal values closely.