ํ๋ฃจ๋๋ผ๋
ํ๋ฃจ๋๋ผ๋๋ ์ฃผ๋ก ๊ฐ์ ๊ณ ์์ด์ ๋ฒผ๋ฃฉ ๋ฐ ์ง๋๊ธฐ ๊ฐ์ผ ์น๋ฃ์ ์๋ฐฉ์ ์ฌ์ฉ๋๋ ์ ์ ์ฑ **์ด์์ฌ์กธ๋ฆฐ๊ณ** ์ธ๋ถ๊ธฐ์์ถฉ ๊ตฌ์ ์ ์ ๋๋ค. ์์ฉ ์๊ฐ์ด ๊ธธ์ด ์ผ๋ฐ์ ์ผ๋ก 1ํ ํฌ์ฌ๋ก ์ต๋ 12์ฃผ๊น์ง ํจ๊ณผ๊ฐ ์ง์๋ฉ๋๋ค. > **์์ ํ:** ๋ฐ๋ ค๊ฒฌ์ฉ ๊ฒฝ๊ตฌ ์ธ์ด๋ธ ์ ์ ๋ ์์ฅ๊ด ํก์๋ฅผ ๊ทน๋ํํ๊ธฐ ์ํด ๋ฐ๋์ ์์๊ณผ ํจ๊ป ํฌ์ฌํด์ผ ํฉ๋๋ค. ๋ฐ์์ด๋ ์ ๊ฒฝ๊ณ ์งํ ๋ณ๋ ฅ์ด ์๋ ๋๋ฌผ์๊ฒ๋ ์ฃผ์ํด์ ์ฌ์ฉํ์ญ์์ค.
์์ฉ ๊ธฐ์ : Fluralaner acts as an ectoparasiticide by antagonizing ligand-gated chloride channels. It specifically targets channels gated by the neurotransmitter **gamma-aminobutyric acid (GABA)** and glutamate (GluCl) โ blocks pre- and post-synaptic transfer of chloride ions across cell membranes โ results in uncontrolled central nervous system activity and death of insects and acarines.
๋๋ฌผ ์ข ๋ณ ์ฉ๋
- Flea and tick treatment and prevention ยท 25-56 mg/kg ยท PO ยท Every 12 weeks ยท 12 weeks ยท Administer with food. Available in 5 sizes of chewable tablets.
- Flea and tick treatment and prevention ยท Standard pipette based on weight (delivering approx 25 mg/kg) ยท topical ยท Every 12 weeks ยท 12 weeks ยท 280 mg/ml spot-on solution. Available in 5 sizes.
- Flea and tick treatment and prevention ยท Standard pipette based on weight (delivering approx 40 mg/kg) ยท topical ยท Every 12 weeks ยท 12 weeks ยท 280 mg/ml spot-on solution. Available in 3 sizes.
- Flea, tick, and nematode treatment and prevention ยท Standard pipette based on weight ยท topical ยท Every 12 weeks ยท 12 weeks ยท Bravecto Plus (280 mg/ml fluralaner and 14 mg/ml moxidectin). Available in 3 sizes.
์ฉ๋์ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์ฐธ๊ณ ์๋ฃ์ ๋๋ค. ํญ์ ์ต์ ๋ผ๋ฒจ๊ณผ ๊ฐ๋ณ ํ์์ ๋ํด ํ์ธํ์ญ์์ค.
ํฌ์ฌ ๊ฒฝ๋ก
๊ธ๊ธฐ
- Known hypersensitivity to fluralaner or any excipients
- Use with caution in dogs or cats with pre-existing epilepsy or seizure disorders
- Known hypersensitivity to fluralaner
- Puppies less than 8 weeks of age or weighing less than 2 kg
- Kittens less than 11 weeks of age or weighing less than 1.2 kg
์ด์๋ฐ์
- Vomiting
- Diarrhea
- Lethargy
- Decreased appetite
- Application site reactions (erythema, pruritus, alopecia for topical forms)
- Rare neurological signs (muscle tremors, ataxia, seizures)
- Neurologic signs (tremors, ataxia, seizures - rare)
- Application site reactions (erythema, pruritus - topical forms)
์ฝ๋ฌผ ์ํธ์์ฉ
- Highly protein-bound drugs (e.g., NSAIDs, warfarin) ยท Fluralaner is highly bound to plasma proteins and might theoretically compete with other highly bound drugs, though clinical significance is generally low. ยท minor
- Highly protein-bound drugs (e.g., NSAIDs) ยท Fluralaner is highly protein-bound and may theoretically compete with other highly bound drugs, though clinical significance is generally considered low. ยท minor
๋ชจ๋ํฐ๋ง
- Efficacy of parasite control
- Signs of gastrointestinal upset
- Neurological status (especially in animals with a history of seizures)
- Adverse neurologic signs (tremors, ataxia, seizures)
๊ณผ์ฉ๋
Fluralaner is generally well tolerated. In safety studies, oral administration of up to 5 times the maximum recommended dose in dogs produced no severe adverse effects. Overdoses may increase the risk of gastrointestinal upset or transient neurological signs. Treatment is symptomatic and supportive.
VetSheet ์ฝ๋ฌผ ๋ ํผ๋ฐ์ค๋ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์์ฌ๊ฒฐ์ ๋ณด์กฐ ๋๊ตฌ์ด๋ฉฐ, ์ ๋ฌธ์ ํ๋จ์ด๋ ์ ์กฐ์ฌ์ ์ต์ ๋ผ๋ฒจ์ ๋์ ํ์ง ์์ต๋๋ค.