ํ๋ฃจ๋ฅด๋นํ๋กํ
ํ๋ฃจ๋ฅด๋นํ๋กํ์ ๊ตญ์ ์๊ณผ์ฉ ๋น์คํ ๋ก์ด๋์ฑ ํญ์ผ์ฆ์ (NSAID)์ ๋๋ค. ์ฃผ๋ก ์๋ด ์์ (์: ๋ฐฑ๋ด์ฅ ์์ ) ์ค ์์ ์ค ์ถ๋์ ์๋ฐฉํ๊ณ ์๊ตฌ ์ผ์ฆ์ ๊ด๋ฆฌํ๋ ๋ฐ ์ฌ์ฉ๋ฉ๋๋ค. **์์ ํ:** ์ ํฌ๋๋ง์ผ์ ์กฐ์ ํ๊ณ ์์ ๋ก ์ธํ ์ถ๋์ ์๋ฐฉํ๋ ๋ฐ ๋งค์ฐ ํจ๊ณผ์ ์ด์ง๋ง, ํ๋ฃจ๋ฅด๋นํ๋กํ๊ณผ ๊ฐ์ ๊ตญ์ NSAID๋ ๊ฐ๋ง ์ํผ ์น์ ๋ฅผ ์ง์ฐ์ํฌ ์ ์์ผ๋ฏ๋ก ๊ธฐ์กด ๊ฐ๋ง ๊ถค์์ด ์๋ ํ์์๊ฒ๋ ๊ทน๋๋ก ์ฃผ์ํด์ ์ฌ์ฉํด์ผ ํฉ๋๋ค.
์์ฉ ๊ธฐ์ : Inhibits **cyclooxygenase (COX)** enzymes, thereby blocking the synthesis of **prostaglandins** from arachidonic acid. โ Reduces ocular inflammation and provides analgesic action. โ Prevents prostaglandin-mediated miosis (constriction of the iris sphincter) during intraocular surgery, acting independently of cholinergic mechanisms.
๋๋ฌผ ์ข ๋ณ ์ฉ๋
- Prevention of intraocular surgical miosis ยท 1 drop in the affected eye(s) ยท Topical ยท Every 30 minutes for 4 doses prior to surgery ยท Pre-operative ยท Standard pre-surgical protocol
- Ocular inflammation (uveitis) ยท 1 drop in the affected eye(s) ยท Topical ยท q6h to q12h ยท As directed by veterinarian ยท Monitor for corneal ulceration
- Prevention of intraocular surgical miosis ยท 1 drop in the affected eye(s) ยท Topical ยท Every 30 minutes for 4 doses prior to surgery ยท Pre-operative ยท Standard pre-surgical protocol
- Ocular inflammation (uveitis) ยท 1 drop in the affected eye(s) ยท Topical ยท q6h to q12h ยท As directed by veterinarian ยท Monitor for corneal ulceration
์ฉ๋์ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์ฐธ๊ณ ์๋ฃ์ ๋๋ค. ํญ์ ์ต์ ๋ผ๋ฒจ๊ณผ ๊ฐ๋ณ ํ์์ ๋ํด ํ์ธํ์ญ์์ค.
ํฌ์ฌ ๊ฒฝ๋ก
๊ธ๊ธฐ
- Hypersensitivity to flurbiprofen or other NSAIDs
- Active corneal ulceration (relative contraindication)
- Bleeding disorders
- Hypersensitivity to NSAIDs
- Active intraocular bleeding
- Corneal ulceration (use with extreme caution)
- Epithelial herpes simplex keratitis
์ด์๋ฐ์
- Transient ocular stinging or burning upon application
- Delayed corneal healing
- Increased risk of ocular bleeding during surgery
- Corneal melting (rare but severe)
- Transient stinging or burning upon instillation
- Ocular irritation
- Increased bleeding tendency of ocular tissues (rare)
์ฝ๋ฌผ ์ํธ์์ฉ
- Topical Corticosteroids ยท Concurrent use may increase the risk of delayed corneal healing and severe complications such as corneal melting. ยท moderate
- Topical Prostaglandin Analogues (e.g., Latanoprost) ยท NSAIDs may blunt the intraocular pressure-lowering efficacy of topical prostaglandins. ยท minor
- Topical prostaglandins (e.g., Latanoprost) ยท NSAIDs may decrease the intraocular pressure-lowering efficacy of topical prostaglandin analogues. ยท minor
๋ชจ๋ํฐ๋ง
- Resolution of ocular inflammation (flare and cells in the anterior chamber)
- Intraocular pressure (IOP)
- Corneal integrity (via fluorescein staining)
- Resolution of ocular inflammation
- Maintenance of pupillary dilation during surgery
- Corneal integrity (via fluorescein staining) if used long-term
๊ณผ์ฉ๋
Topical overdose is unlikely to cause systemic toxicity due to the small volume administered. Ocular overdosage may lead to increased local irritation, hyperemia, and delayed corneal healing. If significant overexposure occurs, flush the eye with sterile saline.
VetSheet ์ฝ๋ฌผ ๋ ํผ๋ฐ์ค๋ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์์ฌ๊ฒฐ์ ๋ณด์กฐ ๋๊ตฌ์ด๋ฉฐ, ์ ๋ฌธ์ ํ๋จ์ด๋ ์ ์กฐ์ฌ์ ์ต์ ๋ผ๋ฒจ์ ๋์ ํ์ง ์์ต๋๋ค.