플루티카손

투여 경로

금기

• Status asthmaticus (not for acute bronchospasm relief)
• Untreated respiratory tract infections
• Known hypersensitivity to fluticasone

이상반응

• Pharyngeal candidiasis (rare)
• Mild systemic adrenal suppression (at very high doses)
• Coughing or gagging during administration

약물 상호작용

• Ketoconazole · May increase systemic fluticasone exposure by inhibiting CYP3A4 metabolism · moderate
• Itraconazole · May increase systemic fluticasone exposure by inhibiting CYP3A4 metabolism · moderate

모니터링

• Clinical signs of respiratory disease (coughing frequency, wheezing, respiratory rate and effort)
• Signs of systemic corticosteroid excess (PU/PD, polyphagia) if on high doses

과용량

Systemic toxicity is highly unlikely with acute overdose due to poor oral bioavailability. Chronic massive overdose may lead to iatrogenic hyperadrenocorticism (Cushing's syndrome) or hypothalamic-pituitary-adrenal (HPA) axis suppression.