플루복사민

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Patients with known hypersensitivity to fluvoxamine or other SSRIs
• Concurrent use of Monoamine Oxidase Inhibitors (MAOIs) such as selegiline or amitraz
• Concurrent use of cisapride

이상반응

• Anorexia/decreased appetite (common)
• Lethargy or sedation
• Gastrointestinal upset (vomiting, diarrhea)
• Anxiety, irritability, or agitation
• Insomnia or hyperactivity
• Panting (dogs)
• Changes in elimination patterns (cats)
• Paradoxical aggressive behavior in previously non-aggressive dogs

약물 상호작용

• Buspirone · Fluvoxamine may paradoxically decrease the clinical efficacy of buspirone.
• Cisapride · Fluvoxamine may increase plasma levels of cisapride, leading to toxicity. Concurrent use is contraindicated.
• Cyproheptadine · May decrease or reverse the effects of SSRIs (useful in treating serotonin syndrome).
• Diazepam, Alprazolam, Midazolam · Fluvoxamine may increase diazepam (and other benzodiazepine) levels.
• Diltiazem · Fluvoxamine may increase the effects of diltiazem; bradycardia has been reported in humans.
• MAO Inhibitors (e.g., amitraz, selegiline) · High risk for serotonin syndrome; contraindicated. A 5-week washout is required after stopping fluvoxamine, and a 2-week washout if stopping the MAOI first.
• Methadone · Fluvoxamine may increase plasma levels of methadone, leading to toxicity.
• Phenytoin · Increased plasma levels of phenytoin possible.
• Propranolol, Metoprolol · Fluvoxamine may increase these beta-blockers' plasma levels; atenolol may be safer.
• Theophylline · Fluvoxamine may increase plasma levels of theophylline.
• Tramadol · SSRIs can inhibit the metabolism of tramadol to active metabolites, decreasing efficacy and increasing toxicity risk (serotonin syndrome, seizures).

모니터링

• Clinical efficacy (behavioral improvement)
• Adverse effects, particularly appetite and body weight
• Baseline liver function tests (consider re-testing as needed)
• ECG (consider baseline and re-test as needed)

과용량

Limited data exists for animals. Any dosage over **10 mg/kg** can reportedly cause tremors and lethargy. **Clinical Signs of Overdose:** Vomiting, somnolence/coma, tremors, diarrhea, hypotension, heart rate/rhythm disturbances (bradycardia/tachycardia, ECG changes), and seizures. Fatalities have been reported in human overdoses. **Treatment:** - Standard protocols for GI decontamination (drug adsorption/removal) for potentially dangerous overdoses. - Symptomatic and supportive therapy. - **Serotonin Syndrome Management:** Cyproheptadine (1.1 mg/kg PO or rectally) may be used as an adjunctive treatment to negate serotonin effects. - **Seizure Control:** Diazepam may be used to treat seizures or other severe neurologic signs.