๊ธ๋ฆฌ๋ฉํผ๋ฆฌ๋
๊ฒฝ๊ตฌ์ฉ, 1์ผ 1ํ ํฌ์ฌํ๋ ํญ๊ณ ํ๋น์ ์ ๋๋ค. ๊ณ ์์ด์ ์ธ์๋ฆฐ ๋น์์กด์ฑ ๋น๋จ๋ณ(NIDDM) ๋ณด์กฐ ์น๋ฃ์ ์ ์ฉํ ์ ์์ต๋๋ค. ๊ณ ์์ด์์์ ์ฌ์ฉ ๊ฒฝํ์ ๋งค์ฐ ์ ํ์ ์ ๋๋ค.
์์ฉ ๊ธฐ์ : Glimepiride is a medium- to long-acting **secretagogue sulfonylurea**. **Primary Mechanism:** - Binds to the **SUR1 receptor** on the membrane of functioning pancreatic beta cells. - Closes ATP-sensitive potassium (K+) channels โ cell depolarization. - Opens voltage-gated calcium (Ca2+) channels โ calcium influx. - Triggers the exocytosis and **release of insulin** granules into the bloodstream. **Secondary Mechanism:** - With continued use, it may also increase peripheral tissue sensitivity to insulin, reducing insulin resistance.
๋๋ฌผ ์ข ๋ณ ์ฉ๋
- Treatment of NIDDM ยท 2 mg (total dose) per cat ยท PO ยท once daily
- Treatment of NIDDM ยท 1-2 mg (total dose per cat) ยท PO ยท once daily
์ฉ๋์ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์ฐธ๊ณ ์๋ฃ์ ๋๋ค. ํญ์ ์ต์ ๋ผ๋ฒจ๊ณผ ๊ฐ๋ณ ํ์์ ๋ํด ํ์ธํ์ญ์์ค.
ํฌ์ฌ ๊ฒฝ๋ก
๊ธ๊ธฐ
- Hypersensitivity to glimepiride or other sulfonylureas
- Diabetic ketoacidosis (DKA)
์ด์๋ฐ์
- Hypoglycemia
- Dizziness
- Asthenia
- Liver function impairment (rare)
- Allergic respiratory reactions (rare)
- Dermatologic reactions (rare)
- Hematologic reactions (rare)
์ฝ๋ฌผ ์ํธ์์ฉ
- Azole Antifungals (ketoconazole, itraconazole, fluconazole) ยท May increase plasma levels of glimepiride
- Beta-Blockers ยท May potentiate hypoglycemic effect
- Chloramphenicol ยท May displace glimepiride from plasma proteins
- Corticosteroids ยท May reduce efficacy
- Thiazide Diuretics ยท May reduce hypoglycemic efficacy
- Isoniazid ยท May reduce hypoglycemic efficacy
- Niacin ยท May reduce hypoglycemic efficacy
- Phenothiazines ยท May reduce hypoglycemic efficacy
- Phenytoin ยท May reduce hypoglycemic efficacy
- Sulfonamides ยท May displace glimepiride from plasma proteins
- Sympathomimetic Agents ยท May reduce hypoglycemic efficacy
- Warfarin ยท May displace glimepiride from plasma proteins
๋ชจ๋ํฐ๋ง
- Fasting blood glucose
- Appetite and attitude
- Body condition
- PU/PD resolution
- Serum fructosamine
- Glycosylated hemoglobin levels
- Signs of hypoglycemia
๊ณผ์ฉ๋
Overdoses can lead to **hypoglycemia**, ranging from mild to severe and life-threatening. **Treatment:** - Immediate **glucose administration** (oral if conscious, IV dextrose if severe/unconscious). - **Intensive monitoring** is critical. - Due to the drug's long duration of activity, patients may require continuous glucose support (e.g., IV dextrose CRI) for **at least 48 hours** post-ingestion, even after apparent clinical recovery.
VetSheet ์ฝ๋ฌผ ๋ ํผ๋ฐ์ค๋ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์์ฌ๊ฒฐ์ ๋ณด์กฐ ๋๊ตฌ์ด๋ฉฐ, ์ ๋ฌธ์ ํ๋จ์ด๋ ์ ์กฐ์ฌ์ ์ต์ ๋ผ๋ฒจ์ ๋์ ํ์ง ์์ต๋๋ค.