글루코사민 / 콘드로이친 황산염
Glucosamine / Chondroitin Sulfate
2-amino-2-deoxy-beta-D-glucopyranose / chondroitin polysulfate
다른 이름: Cosequin · Dasuquin · Restor-A-Flex · ProMotion · Seraquin · chitosamine · NSC-758 · 2-amino-2-deoxy-beta-D-glucopyranose · G6SD-glucosamine · amino monosaccharide · chondroitin 4-sulfate · chondroitin sulfate A/B/C · CSA · sodium chondroitin sulfate · chondroitin polysulfate · CDA · CSCSC · GAG · galactosaminogluconoglycan sulfate
VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
동물 종별 용량
🌎 NA — North America🌍 EU — Europe
개
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Adjunctive treatment of chronic pain | 13-15 mg/kg (of the chondroitin component) PO once daily (q24h) | PO | q24h | — | 🌎 NA |
| Adjunctive treatment of cancer pain | 15-30 mg/kg (of the chondroitin component) PO once daily (q24h) for 4-6 weeks then half the dose | PO | q24h | 4-6 weeks then half dose | 🌎 NA |
| Adjunctive treatment of chronic pain | 13-15 mg/kg (of the chondroitin component) PO once daily or every other day (q24-48h) | PO | q24-48h | — | 🌎 NA |
| Dietary Supplement (Cosequin Regular Strength) - Small Dogs <25 lbs | under 10 lb.: 1/2 to 1 capsule daily; 10-24 lb.: 2 capsules daily (1 in AM; 1 in PM). Maintenance Administration (after initial 4-6 week period): under 10 lb. can often have their dosage reduced to 1/2 capsule daily or 1 capsule every other day. 10 to 24 lb. can often have their dosage reduced to 1 capsule daily. | PO | q12h-q24h | Initial 4-6 weeks, then maintenance | 🌎 NA |
| Dietary Supplement (Cosequin DS) - Medium/Large Dogs >25 lbs | 25-49 lb.: 2 capsules daily (1 in AM; 1 in PM); 50-100 lb.: 3 capsules daily (2 in AM; 1 in PM); over 100 lb.: 4 capsules daily (2 in AM; 2 in PM). Maintenance Administration (after initial 4-6 week period): dogs can have their total daily dosage gradually lowered until maintenance level is reached. | PO | Divided daily | Initial 4-6 weeks, then maintenance | 🌎 NA |
고양이
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Adjunctive treatment of cancer pain | 15-30 mg/kg (of the chondroitin component) PO once daily (q24h) for 4-6 weeks then half the dose | PO | q24h | 4-6 weeks then half dose | 🌎 NA |
| Adjunctive treatment of chronic pain | 15-20 mg/kg (of the chondroitin component) PO once daily or every other day (q24-48h) | PO | q24-48h | — | 🌎 NA |
| Dietary Supplement (Cosequin For Cats) | Initially: under 10 lb.: 1 capsule sprinkled on food daily; over 10 lb.: 2 capsules sprinkled on food daily (1 in AM/1 in PM). Maintenance Administration (after initial 4-6 week period): once desired response is obtained, capsules may be administered every other day. | PO | q24h or divided | Initial 4-6 weeks, then maintenance | 🌎 NA |
말
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Navicular syndrome | 16.5 grams (5 scoops) in feed twice daily | PO | q12h | — | 🌎 NA |
| Dietary Supplement (Cosequin Concentrated Powder) | Initially: for horses under 600 lb., 2 scoops in AM and 2 scoops in PM; horses 600-1,200 lb., 3 scoops in AM and 3 scoops in PM; horses over 1,200 lb., 4 scoops in AM and 4 scoops in PM. Suggested Maintenance Administration: horses under 600 lb., 1 scoop daily; horses 600-1,200 lb., 1-2 scoops daily; horses over 1,200 lb., 2 scoops daily. | PO | Divided AM/PM | Initial 2-4 weeks, then maintenance | 🌎 NA |
- Navicular syndrome: Using Cosequin Concentrated Powder
- Dietary Supplement (Cosequin Concentrated Powder): Transition Period: Do not lower amount until horse has begun to respond. Reduce total daily amount by one level scoop each week.
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
개요
글루코사민과 콘드로이친 황산염은 개, 고양이, 말의 골관절염 및 기타 통증성 관절 질환의 보조 치료제로 널리 사용되는 기능성 영양 보충제입니다. 요로 보호층에 글리코사미노글리칸이 존재하기 때문에 고양이 하부 요로 질환(FLUTD)이 있는 고양이의 방광 건강을 지원하는 데에도 때때로 사용됩니다.
임상 요점: 이 제품들은 FDA의 의약품 규제를 받지 않기 때문에 제조업체에 따라 제품의 품질, 순도 및 생체 이용률이 크게 다를 수 있습니다. 독립적인 품질 테스트와 임상 시험을 거친 신뢰할 수 있는 동물용 제품(예: Cosequin®)을 사용하는 것이 강력히 권장됩니다.
임상적 효능에 대해서는 때때로 논쟁이 있고 대규모의 결정적인 연구는 부족하지만, 이러한 보충제는 일반적으로 매우 안전한 것으로 간주되며 관절 건강 및 만성 통증 관리를 위한 다각적 접근 방식의 일부로 자주 사용됩니다.
작용 기전
These compounds work synergistically to support cartilage matrix synthesis and inhibit cartilage degradation:
- Glucosamine: Acts as a primary building block for cartilage. Chondrocytes utilize glucosamine to synthesize glycosaminoglycans (GAGs) and hyaluronan. It also regulates the synthesis of collagen and proteoglycans and exhibits mild anti-inflammatory properties by scavenging free radicals.
- Chondroitin Sulfate: Provides structural integrity to cartilage. It actively inhibits destructive enzymes (such as metalloproteinases) in joint fluid and cartilage. It also stimulates the production of GAGs and proteoglycans, and may reduce thrombi formation in the microvasculature of the joint.
Pathway: Exogenous Glucosamine + Chondroitin → Uptake by Chondrocytes → ↑ GAG & Hyaluronan Synthesis + ↓ Cartilage Degrading Enzymes → Improved Joint Fluid Viscosity & Cartilage Health.
안전성·주의사항
금기사항
- Known hypersensitivity to glucosamine or chondroitin
부작용
- Mild gastrointestinal upset
- Flatulence
- Stool softening or mild diarrhea
- Hypersensitivity reactions (rare, as products are derived from natural sources)
주의
Use with caution in patients with bronchoconstrictive conditions (e.g., asthma), as glucosamine has been reported to exacerbate asthma symptoms in humans. Product quality varies widely; choose products with proven bioavailability. Products containing manganese could lead to manganese toxicity if given at very high dosages chronically.
약물 상호작용
Glucosamine may induce resistance to this agent by reducing its inhibition of topoisomerase II.
Glucosamine may induce resistance to this agent by reducing its inhibition of topoisomerase II.
High doses of chondroitin/glucosamine may enhance coagulation effects and theoretically increase the International Normalized Ratio (INR).
High doses potentially could enhance the effects of heparin or other drugs that affect coagulation.
모니터링
- Clinical efficacy (improvement in mobility, reduction in pain, or improvement in urinary signs for FLUTD)
약동학
흡수
Both glucosamine HCl and glucosamine sulfate are absorbed in the gut after the salt is cleaved in the stomach. Purified, low molecular weight chondroitin appears to be absorbed from the gut. Reported bioavailability in horses is ~25% for chondroitin sulfate and ~2% for glucosamine. In dogs, bioavailability is ~5% for chondroitin sulfate and ~12% for glucosamine.
과다투여
Oral overdosage is highly unlikely to cause significant systemic problems. The LD50 for the combined compound in rats is greater than 5 g/kg.
- Clinical Signs: Massive ingestions may result in gastrointestinal effects (vomiting, diarrhea). Theoretical changes in coagulation parameters could occur but have not been documented.
- Toxicity Note: Products containing manganese could lead to manganese toxicity if given in very high dosages chronically above label recommendations.
제품
제형
- Capsules
- Chewable tablets
- Powder
- Soft chews
동물용의약품
- Cosequin®
- Restor-A-Flex®
- OsteO-3®
- Arthri-Nu®
- ProMotion®
- Seraquin®
- Oste-O-Guard®
- Caniflex®
- Equi-Phar Flex®
인용의약품
- Various over-the-counter nutritional supplements (None as FDA-approved pharmaceuticals)
규제 현황
규제 데이터 없음: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
보관·안정성
Check individual product labels for specific storage and expiration information. Chondroitin sulfate is extremely hygroscopic (absorbs moisture from the air). Generally, these products should be stored in tight containers at room temperature, avoiding direct sunlight.
보호자 정보
- 인내심이 필요합니다: 눈에 띄는 임상적 개선이 나타나려면 2~6주 동안 꾸준히 매일 투여해야 할 수 있습니다.
- 일관성이 중요합니다: 시판되는 일반 보충제는 품질 차이가 매우 크므로, 수의사와 먼저 상의하지 않고 처방받은 브랜드를 임의로 변경하지 마십시오.
- 투여 방법: 알약은 간식처럼 주거나 부수어서 사료에 섞어 줄 수 있습니다. 캡슐은 열어서 내용물을 습식 사료나 물에 살짝 적신 건식 사료 위에 뿌려주어 반려동물이 정량을 모두 섭취하도록 할 수 있습니다.
- 부작용: 부작용이 나타날 가능성은 매우 낮지만, 가벼운 위장 장애(무른 변, 가스)가 보고된 바 있습니다. 이러한 증상이 불편을 초래할 경우 수의사에게 연락하십시오.
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