글리코피로늄 / 글리코피롤레이트

투여 경로

금기

• Concurrent use with alpha-2 adrenergic agonists is not recommended

이상반응

• Tachycardia
• Ventricular arrhythmias
• Thickened, sticky airway secretions
• Paradoxical bradycardia (at very low IV doses)

약물 상호작용

• Barbiturates (alkaline drugs) · In vitro incompatibility; a precipitate may form if mixed together · major
• Sympathomimetics · Antimuscarinics may enhance the actions of sympathomimetics · moderate
• Thiazide diuretics · Antimuscarinics may enhance the actions of thiazide diuretics · moderate
• Antihistamines · May enhance the anticholinergic activity of glycopyrronium · moderate
• Pethidine · May enhance the anticholinergic activity of glycopyrronium · moderate
• Benzodiazepines · May enhance the anticholinergic activity of glycopyrronium · moderate
• Phenothiazines · May enhance the anticholinergic activity of glycopyrronium · moderate
• Alpha-2 adrenergic agonists · Combining glycopyrronium and alpha-2 adrenergic agonists is not recommended due to conflicting cardiovascular effects · major

모니터링

• Heart rate and rhythm (ECG)
• Respiratory rate and airway patency

과용량

Tachycardias following an overdose of glycopyrronium are usually transient and do not require management. If severe ventricular arrhythmias occur, they may be treated with **lidocaine**.