고나도렐린

호르몬제

고나도렐린은 합성 **시상하부 호르몬**(GnRH 유사체)으로, 수의학에서 주로 젖소의 난소 여포 낭종과 같은 생식기 질환을 치료하는 데 사용됩니다. 주요 특징: - **작용 시간이 매우 짧음**(수분). - 소동물에서는 진단 목적(예: 거세 여부 감별, 잠복고환 확인) 및 발정이나 배란 유도를 위해 허가 외(off-label)로 사용됩니다. - 산업동물에 사용 시 **휴약 기간(도축 및 착유)이 필요 없음**. - 매우 안전하며 보고된 부작용이 거의 없습니다.

작용 기전: Gonadorelin acts as a synthetic **GnRH** (Gonadotropin-Releasing Hormone) → binds to receptors on the anterior pituitary gland → stimulates a surge-like release of **FSH** (Follicle Stimulating Hormone) and **LH** (Luteinizing Hormone). - In females (cows, ewes, cats), this LH surge can induce ovulation or luteinization of cystic follicles. - In males, it stimulates testosterone release, which is useful for diagnostic stimulation testing. - Note: A constant infusion initially stimulates LH/FSH release, but eventually causes receptor downregulation and levels return to baseline.

동물 종별 용량

Sheep

To induce ovulation outside of the breeding season · 100 micrograms injected daily · Injection · q24h · 4-5 days

Goats

To induce ovulation outside of the breeding season in the doe · 100 micrograms injected daily · Injection · q24h · 4-5 days

Cats

To stimulate ovulation after mating · 25 micrograms IM after mating · IM · Once
For infertility, reduced libido, testis descent in male cats · 1 microgram/kg every 2-3 days · IM · q48-72h
To detect ovarian remnants in queens after ovariohysterectomy · 25 micrograms per cat · IM · Once · Progesterone level (>1 ng/mL) 1-2 weeks post treatment verifies presence of ovarian tissue.

Ferrets

To induce ovulation · 20 micrograms IM · IM · Once · Repeat in one week as necessary · Most effective 14 days after onset of estrus.

Cattle

To treat ovarian cysts in cattle · 100 micrograms IM or IV · IM/IV · Once
To treat ovarian cysts in cattle · 100 micrograms IM per cow · IM · Once

Dogs

GnRH stimulation test to differentiate castration from cryptorchidism · 50 micrograms IM (Take pre-sample, give injection, 2-3 hours later take post-injection sample) · IM · Once · Castrated dogs have testosterone concentrations <0.1 ng/mL and GnRH does not stimulate.
GnRH stimulation test to determine if dog has retained testicle · 2.5 micrograms/kg IM (if very small dog use 25 micrograms total dose instead) · IM · Once · Take pre-sample, give injection, take second sample in 60-90 minutes.
To aid in the descent of cryptorchid testes · 50-100 micrograms SC or IV · SC/IV · Once · Repeat in 4-6 days if no response
To increase libido in male dogs · 50-100 micrograms IM weekly · IM · Weekly · 4 to 6 weeks · Anecdotal use.
For cystic ovarian disease in bitches · 3.3 micrograms/kg IM once daily · IM · q24h · 3 days · Elevated progesterone (>2 ng/mL) 1-2 weeks post treatment verifies success.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

IMIVSC

금기

None noted on the label

이상반응

None reported
Hypersensitivity reactions are highly unlikely with synthetic preparations

모니터링

Clinical efficacy (e.g., resolution of cystic ovaries, induction of estrus)
Serum progesterone levels (for ovarian remnant or cystic ovary verification)
Serum testosterone levels (for cryptorchidism/castration testing)

과용량

In doses of up to 120 micrograms/kg, no untoward effects were noted in several species of test animals. Gonadorelin is unlikely to cause significant adverse effects after inadvertent overdosage.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.