그리세오풀빈
Griseofulvin
다른 이름: Fulvicin · AmTech Griseofulvin · Grifulvin V · Gris-PEG · Curling factor · Griseofulvina · Griseofulvinum
VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
동물 종별 용량
🌎 NA — North America🌍 EU — Europe
개
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Susceptible dermatophytic infections | Microsize: 25 mg/kg q12h PO for 42-56 days; Ultramicrosize: 5-10 mg/kg PO once daily for 42 days. | PO | q12h or once daily | 42-56 days | 🌎 NA |
| Susceptible dermatophytic infections | Microsize: 50 mg/kg PO once daily with fatty meal. | PO | once daily | Prolonged | 🌎 NA |
- Susceptible dermatophytic infections: May need to treat longer for Trichophyton than for Microsporum. Give following a fatty meal or administration of corn oil. Continue for at least 2 weeks after resolution of signs and at least 5 months for onychomycosis.
- Susceptible dermatophytic infections: Used with topical therapy. May double dose in resistant cases. If GI distress occurs may divide dose and give twice daily with food. Begin taking cultures after 4 weeks. Continue therapy for 2 weeks beyond clinical cure and when 2-3 negative cultures are obtained at weekly intervals.
고양이
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Susceptible dermatophytic infections | Microsize: 50-120 mg/kg PO; divided daily. Ultramicrosize: 10-15 mg/kg PO twice daily. | PO | divided daily or twice daily | 4-6 weeks or longer | 🌎 NA |
| Susceptible dermatophytic infections | Microsize: 50 mg/kg PO once daily or 25 mg/kg PO q12h for 42-70 days; Ultramicrosize: 5-10 mg/kg PO once daily for 42 days. | PO | once daily or q12h | 42-70 days | 🌎 NA |
| Susceptible dermatophytic infections | Microsize: 50 mg/kg PO once daily with fatty meal. | PO | once daily | Prolonged | 🌎 NA |
| Feline eosinophilic granuloma complex | Microsize: 25 mg/kg PO twice daily with food. | PO | twice daily | At least one month | 🌎 NA |
- Susceptible dermatophytic infections: Give with a fatty meal. Treat until culture is negative.
- Susceptible dermatophytic infections: Give following a fatty meal or administration of corn oil. Continue for at least 2 weeks after resolution of signs and at least 5 months for onychomycosis.
- Susceptible dermatophytic infections: Used with topical therapy. May double dose in resistant cases. If GI distress occurs may divide dose and give twice daily with food. Begin taking cultures after 4 weeks. Continue therapy for 2 weeks beyond clinical cure and when 2-3 negative cultures are obtained at weekly intervals.
- Feline eosinophilic granuloma complex: Give at least for one month to judge efficacy.
소형 포유류
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Advanced dermatophytosis (Rabbits) | Ultramicrosize 6.25 mg/kg PO q12h for 4-6 weeks. Microsize: 25 mg/kg PO q12-24h for one month | PO | q12h or q12-24h | 4-6 weeks or 1 month | 🌎 NA |
| Susceptible dermatophytic infections (Chinchillas) | 25 mg/kg PO once daily for 30-60 days | PO | once daily | 30-60 days | 🌎 NA |
| Susceptible dermatophytic infections (Gerbils, Guinea pigs, Hamsters, Rats) | 25 mg/kg PO q24h for 14-28 days | PO | q24h | 14-28 days | 🌎 NA |
| Susceptible dermatophytic infections (Mice) | 25 mg/kg PO q24h for 14 days | PO | q24h | 14 days | 🌎 NA |
| Susceptible dermatophytic infections (Chinchillas) | 25 mg/kg PO q24h for 28-40 days | PO | q24h | 28-40 days | 🌎 NA |
| Dermatophytosis (Guinea pigs) | 25 mg/kg PO (as a suspension) once daily for 28 days. | PO | once daily | 28 days | 🌎 NA |
| Susceptible dermatophytic infections (Chinchillas) | 25 mg/kg PO once daily (q24h) for 30 days | PO | once daily | 30 days | 🌎 NA |
새
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Susceptible dermatophytic infections (Ratites) | 35-50 mg/kg PO once daily | PO | once daily | — | 🌎 NA |
말
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Susceptible dermatophytic infections | Using the microsize (not ultra-microsize) products: 5 mg/kg PO once daily. | PO | once daily | — | 🌎 NA |
- Susceptible dermatophytic infections: Smaller doses (1.25 grams) should be used for foals or ponies. If using ultra-microsize (human) formulations the dose should be reduced by 50%.
소
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Susceptible dermatophytic infections | Ultramicrosize: 10-20 mg/kg PO once daily for 1-2 weeks. 100 mg/kg PO given twice (or more) 1 week apart may also be effective. | PO | once daily or weekly | 1-2 weeks | 🌎 NA |
| Susceptible dermatophytic infections | 20 mg/kg PO once daily for 6 weeks | PO | once daily | 6 weeks | 🌎 NA |
- Susceptible dermatophytic infections: Not FDA-approved for use in food animals and can be very expensive.
돼지
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Susceptible dermatophytic infections | 20 mg/kg PO once daily for 6 weeks | PO | once daily | 6 weeks | 🌎 NA |
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
개요
그리세오풀빈은 수의학에서 주로 피부, 털, 발톱의 피부사상균 감염(백선)을 치료하는 데 사용되는 정진균성 항생제입니다.
주요 임상 포인트: 피부사상균(Trichophyton, Microsporum, Epidermophyton* 등)에 대해 높은 특이성을 가집니다. 세균, 기타 병원성 진균 또는 말라세지아* 효모에는 효과가 없습니다.
- 임상 팁: 심각한 부작용(특히 골수 억제 및 기형 유발성)의 가능성과 장기 치료의 필요성 때문에, 현대 수의학에서는 이트라코나졸 및 테르비나핀과 같은 더 안전한 신형 항진균제로 점차 대체되고 있습니다.
- 위장관 흡수율의 차이로 인해 미세입자(microsize)와 초미세입자(ultramicrosize) 제형 간의 투여량이 크게 다릅니다.
작용 기전
Griseofulvin is a fungistatic agent. It enters susceptible fungal cells and binds to tubulin, which disrupts the structure of the mitotic spindle → arresting the metaphase of cell division.
Additionally, griseofulvin binds to newly synthesized keratin in the host. As new skin, hair, and nails grow, the keratin-griseofulvin complex makes these newly formed tissues resistant to fungal invasion, allowing the infected, older tissues to be shed.
안전성·주의사항
금기사항
- Pregnancy (known teratogen)
- Known hypersensitivity to griseofulvin
- Hepatocellular failure
- Horses intended for food
부작용
- Anorexia
- Vomiting
- Diarrhea
- Anemia
- Neutropenia
- Leukopenia
- Thrombocytopenia
- Depression
- Ataxia
- Hepatotoxicity
- Dermatitis/photosensitivity
- Toxic epidermal necrolysis
- Teratogenesis
주의
Important Warnings:
- Feline Sensitivity: Cats, particularly kittens, are highly susceptible to adverse effects (e.g., bone marrow depression), likely due to slower glucuronide conjugation. Monitor carefully.
- FIV Testing: Cats should be tested for FIV before initiating therapy due to the drug's potential neutropenic or panleukopenic effects.
- Teratogenicity: Griseofulvin is a known teratogen (causes cleft palate, skeletal/brain malformations). It is strictly contraindicated in pregnant animals. It may also inhibit spermatogenesis.
- Absorption: Must be given with a fatty meal to ensure adequate GI absorption.
약물 상호작용
Griseofulvin may potentiate the effects of alcohol.
Griseofulvin may decrease salicylate levels.
Griseofulvin may decrease cyclosporine levels.
May decrease griseofulvin blood concentrations by inducing hepatic microsomal enzymes and/or reducing absorption. Dosage adjustment may be necessary.
May decrease theophylline half-life and levels in some patients.
May reduce the anticoagulant activity of coumarin anticoagulants; adjustment may be required.
모니터링
- Clinical efficacy; fungal culture
- Adverse effects
- CBC; before therapy and q1-3 weeks during therapy
- Liver enzymes (if indicated)
약동학
반감기
흡수
Microsized form is variably absorbed (25-70%); dietary fat enhances absorption. Ultramicrosize form is nearly 100% absorbed (approximately 1.5 times as well as the microsized form).
분포
Concentrates in skin, hair, nails, fat, skeletal muscle, and the liver. Can be found in the stratum corneum within 4 hours of dosing.
대사
Metabolized by the liver via oxidative demethylation and glucuronidation to 6-desmethylgriseofulvin (inactive).
배설
Less than 1% of the drug is excreted unchanged in the urine.
과다투여
Specifics regarding acute toxicity are limited. Significant overdoses should be managed with gut emptying, activated charcoal, and cathartic administration unless contraindicated. Horses have tolerated 100 mg/kg PO for 20 days without apparent ill effect.
제품
제형
- Powder
- Oral Tablets
- Oral Suspension
동물용의약품
- AmTech® Griseofulvin Powder: 2.5 g griseofulvin in 15 g sachets (FDA-approved for horses not intended for food)
인용의약품
- Grifulvin V® Griseofulvin Microsize Oral Tablets: 500 mg
- Griseofulvin Microsize Oral Suspension: 125 mg/5 mL
- Gris-PEG® Griseofulvin Ultramicrosize Tablets: 125 mg & 250 mg
규제 현황
규제 데이터 없음: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
보관·안정성
Store at less than 40°C, preferably at room temperature (15-30°C). Suspensions should be stored in tight, light-resistant containers. Microsize tablets/capsules should be stored in tight containers; ultramicrosize tablets in well-closed containers.
보호자 정보
중요: 그리세오풀빈은 선천적 결함을 유발할 수 있습니다. 임산부는 이 약물의 취급을 피하거나, 투여가 필요한 경우 장갑을 착용해야 합니다.
- 투여 방법: 체내 흡수를 돕기 위해 반드시 지방이 많은 음식(예: 소량의 통조림 사료, 버터 또는 옥수수 기름)과 함께 투여하십시오.
- 순응도: 백선 치료에는 시간이 걸립니다. 반려동물의 상태가 좋아진 것 같더라도 처방된 대로 정확히 약을 계속 투여하십시오. 너무 일찍 중단하면 감염이 재발할 수 있습니다.
- 환경 관리: 백선은 다른 반려동물과 사람에게 전염성이 매우 높습니다. 수의사의 지시에 따라 집안을 소독하고, 낡은 침구를 폐기하며, 필요한 경우 반려동물을 격리하십시오.
- 부작용: 식욕 부진, 구토 또는 설사가 있는지 관찰하십시오. 반려동물이 무기력해 보이거나, 비틀거리거나, 비정상적인 증상을 보이면 즉시 수의사에게 연락하십시오.
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