헤모글로빈 글루타머-200 (소 유래)

반합성 헤모글로빈 대체제 / 콜로이드

**헤모글로빈 글루타머-200 (소 유래)**는 수의학에서 주로 산소 운반 수액 및 강력한 콜로이드로 사용되는 반합성 중합 소 헤모글로빈 제품입니다. * **주요 적응증**: 전혈이나 농축 적혈구를 구할 수 없거나 교차시험에서 적합한 공혈동물을 찾지 못한 경우의 빈혈(용혈, 출혈 또는 무효 조혈로 인한) 치료. * **임상적 진주**: 재생성 빈혈 및 응급 외상 상황에서 특히 유용합니다. 기질이 없고 적혈구 막이 없기 때문에 투여 전 혈액형 검사나 교차시험이 필요하지 않습니다. * **허가 외 사용**: 고양이 및 신생아 동종면역 용혈성 빈혈이 있는 망아지에게도 사용된 바 있으나, 강력한 콜로이드 특성으로 인해 극도의 주의가 필요합니다.

작용 기전: HG-200 functions both as an oxygen carrier and a potent colloid expander: * **Oxygen Delivery**: Releases oxygen to tissues similarly to endogenous hemoglobin. It **shifts the oxygen dissociation curve to the right**, facilitating easier oxygen offloading to hypoxic tissues. * **Microvascular Perfusion**: Due to its small molecular size compared to intact RBCs, it can bypass severe arterial constrictions to oxygenate ischemic cells. * **Colloidal Effect**: Acts as a potent colloid (similar to dextran 70 or hetastarch), expanding intravascular volume by increasing oncotic pressure. * **Vascular Tone**: Causes significant **vasoconstriction**, which can increase blood pressure but may decrease cardiac output in hypovolemic states.

동물 종별 용량

Cats

As an option to provide oxygen carrying capacity in the trauma patient · 2.5-10 mL/kg · IV · Given over several hours · Care must be taken not to cause fluid overload especially in cats.

Dogs

Labeled indications (anemia) · 10-30 mL/kg · IV · One-time dose at a rate of up to 10 mL/kg/hr · Do not administer with other fluids or drugs via the same infusion set.
Resuscitation of trauma patients in shock with or without hemorrhage · 3-5 mL/kg · IV · Once · With concurrent crystalloid at 1/2 to 2 times maintenance.
To provide a 'bridge' until immunosuppressive drugs take effect in dogs with IMHA with a transfusion reaction · 7-10 mL/kg or 30 mL/kg · IV · q12h (for 7-10 mL/kg dose) · 48-72 hours (for 30 mL/kg dose) · 7-10 mL/kg maintains Hb >3.5 g/dL; 30 mL/kg provides support for 48-72h.
As an option to provide oxygen carrying capacity in the trauma patient · 10-15 mL/kg · IV · Given over several hours · Care must be taken not to cause fluid overload.
As a vasopressor once there is adequate intravascular volume in trauma patients · 3-5 mL/kg · IV · Once

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

Advanced cardiac disease (e.g., congestive heart failure)
Severely impaired cardiac function
Renal impairment with oliguria or anuria

이상반응

Discolored mucous membranes, sclera, skin (yellow, red, brown)
Discolored urine (orange, red, brown)
Increased central venous pressure (CVP)
Ventricular arrhythmias (AV block, tachycardia, VPCs)
Vomiting, diarrhea, anorexia
Tachypnea, dyspnea, harsh lung sounds
Pulmonary edema and pleural effusion (due to volume overload)
Fever
Peripheral edema
Hemoglobinuria

모니터링

Hemoglobin levels
Clinical signs of adequate tissue oxygenation
Central venous pressure (CVP) and signs of circulatory overload
Respiratory rate and effort (watch for pulmonary edema)
Heart rate and rhythm (watch for arrhythmias)

과용량

Clinical signs of overdosage (1 to 3 times the recommended dose) include yellow-orange discoloration of skin, mucous membranes, and sclera; red-dark-green-black feces; brown-black urine; decreased appetite/thirst; vomiting; diarrhea; and decreased skin elasticity. Overdosage or excessively rapid administration (>10 mL/kg/hr) may result in severe circulatory overload (pulmonary edema, pleural effusion).

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.