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Hydrocortisone

국소 코르티코스테로이드 (저역가)topicalPOIVIMTopical개고양이

다른 이름: Corticalm · Sulfodene HC · Zymox · Dermacool HC · Cortisoothe · Efcortesol · Solu-cortef · Cortisol

VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료

Initially used sparingly 1-4 times per day and then frequency is tapered when control is achieved. Shampoos: once a day to once a week (leave on 10 mins).topical· q6-24h· < 2 months

용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.

동물 종별 용량

🌎 NA — North America🌍 EU — Europe

개

적응증용량경로빈도기간지역
Focal or multifocal pruritic/inflammatory lesionsInitially used sparingly 1-4 times per day and then frequency is tapered when control is achieved. Shampoos: once a day to once a week (leave on 10 mins).topicalq6-24h< 2 months🌎 NA

고양이

적응증용량경로빈도기간지역
Focal or multifocal pruritic/inflammatory lesionsInitially used sparingly 1-4 times per day and then frequency is tapered when control is achieved. Shampoos: once a day to once a week (leave on 10 mins).topicalq6-24h< 2 months🌎 NA

용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.

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개요

저역가 국소 코르티코스테로이드로 간주되며, 국소적인 가려움증 및/또는 염증 상태의 보조 치료에 유용합니다. 고역가 스테로이드에 비해 위험이 현저히 낮아 넓은 부위나 소형 환자를 치료할 때 합리적인 첫 번째 선택입니다.

작용 기전

Corticosteroids are non-specific anti-inflammatory agents. They act by inducing ​phospholipase A2 inhibitory proteins (lipocortins)​ in cells → reducing the formation, activity, and release of endogenous inflammatory mediators (e.g., histamine, prostaglandins, kinins).

They also reduce DNA synthesis via an anti-mitotic effect on epidermal cells and inhibit the migration of leukocytes and macrophages to the area, reducing erythema, pruritus, and edema.

안전성·주의사항

금기사항

  • Tuberculosis of the skin
  • Pregnancy (relative contraindication)
  • Pregnant animals
  • Renal disease (systemic use generally contraindicated)
  • Diabetes mellitus (systemic use generally contraindicated)

부작용

  • Skin atrophy (with long-term use)
  • Skin fragility
  • Superficial follicular cysts (milia)
  • Comedones
  • HPA axis suppression (rare, but possible with long-term use)
  • Weight loss (catabolic effect)
  • Cutaneous atrophy
  • Iatrogenic hyperadrenocorticism (PU/PD, elevated liver enzymes)
  • Vomiting
  • Diarrhoea
  • Gastrointestinal ulceration
  • Increased urine glucose levels
  • Decreased serum T3 and T4 values
  • Hypothalamic-pituitary axis suppression (with prolonged use)
  • Adrenal atrophy
  • Impaired wound healing
  • Delayed recovery from infections
  • Brain damage (if hyponatraemia is corrected excessively rapidly)

주의

Important: Clients should wash hands after application or wear gloves. Avoid contact with eyes. Do not allow the animal to lick or chew at affected sites for at least 20-30 minutes after application.

Residual activity may affect intradermal or allergy serum tests; stop use 2 weeks prior to allergy testing.

약물 상호작용

NSAIDsMajor

Increased risk of gastrointestinal ulceration

InsulinMajor

Glucocorticoids antagonize the effect of insulin

PhenobarbitalModerate

May accelerate the metabolism of corticosteroids

ItraconazoleModerate

May decrease the metabolism of corticosteroids

AcetazolamideModerate

Increased risk of hypokalaemia

Amphotericin BMajor

Increased risk of hypokalaemia

FurosemideModerate

Increased risk of hypokalaemia

Thiazide diureticsModerate

Increased risk of hypokalaemia

모니터링

  • Resolution of clinical signs (pruritus, erythema)
  • Signs of skin atrophy or secondary infection
  • Serum electrolytes (especially Sodium and Potassium)
  • Liver enzymes
  • Blood and urine glucose
  • Clinical signs of GI ulceration
  • Thyroid panel (T3, T4) if indicated

약동학

흡수

Systemic absorption is rare but possible with long-term use over large areas.

과다투여

Overdose via topical application is unlikely, but chronic overuse can lead to iatrogenic hyperadrenocorticism (Cushing's syndrome) and HPA axis suppression.

제품

제형

  • Lotion
  • Wipes
  • Ointment
  • Spray
  • Shampoo
  • Topical cream (0.5%, 1%)
  • Topical solution (1%)
  • Injectable solution (25 mg/ml)
  • Injectable powder for reconstitution (100 mg, 500 mg)
  • Oral tablets (10 mg, 20 mg)

동물용의약품

  • Corticalm Lotion 1%
  • Sulfodene HC Anti-Itch Lotion 0.5%
  • Zymox Topical Cream/Wipes/Spray 1%
  • Dermacool HC Spray 1%
  • Cort/Astrin Solution 1%
  • Cortisoothe Shampoo

인용의약품

  • Hydrocortisone Ointment 0.5%, 1%, 2.5%
  • Hydrocortisone Cream 0.5%, 1%
  • Hydrocortisone Spray 1%
  • Efcortesol
  • Solu-cortef
  • Hydrocortisone 10 mg, 20 mg tablets
  • Hydrocortisone 0.5%, 1% creams

규제 현황

European Union✓ 승인됨처방전의약품EMA
🐕 Dogs🐈 Cats

POM (Prescription Only Medicine)

United Kingdom✓ 승인됨처방전의약품VMD
🐕 Dogs🐈 Cats

POM-V

규제 데이터 없음: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

보관·안정성

Store at room temperature away from moisture and heat.

보호자 정보

약을 바른 후에는 손을 씻거나 장갑을 착용하십시오. 눈에 닿지 않게 하십시오. 약을 바른 후 최소 20~30분 동안은 반려동물이 환부를 핥거나 씹지 못하게 하십시오.

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