ํ๋๋ก์ฝ๋ฅดํฐ์
์ ์ญ๊ฐ ๊ตญ์ ์ฝ๋ฅดํฐ์ฝ์คํ ๋ก์ด๋๋ก ๊ฐ์ฃผ๋๋ฉฐ, ๊ตญ์์ ์ธ ๊ฐ๋ ค์์ฆ ๋ฐ/๋๋ ์ผ์ฆ ์ํ์ ๋ณด์กฐ ์น๋ฃ์ ์ ์ฉํฉ๋๋ค. ๊ณ ์ญ๊ฐ ์คํ ๋ก์ด๋์ ๋นํด ์ํ์ด ํ์ ํ ๋ฎ์ ๋์ ๋ถ์๋ ์ํ ํ์๋ฅผ ์น๋ฃํ ๋ ํฉ๋ฆฌ์ ์ธ ์ฒซ ๋ฒ์งธ ์ ํ์ ๋๋ค.
์์ฉ ๊ธฐ์ : Corticosteroids are non-specific anti-inflammatory agents. They act by inducing **phospholipase A2 inhibitory proteins (lipocortins)** in cells โ reducing the formation, activity, and release of endogenous inflammatory mediators (e.g., **histamine, prostaglandins, kinins**). They also reduce DNA synthesis via an anti-mitotic effect on epidermal cells and inhibit the migration of leukocytes and macrophages to the area, reducing erythema, pruritus, and edema.
๋๋ฌผ ์ข ๋ณ ์ฉ๋
- Focal or multifocal pruritic/inflammatory lesions ยท Initially used sparingly 1-4 times per day and then frequency is tapered when control is achieved. Shampoos: once a day to once a week (leave on 10 mins). ยท topical ยท q6-24h ยท < 2 months
- Focal or multifocal pruritic/inflammatory lesions ยท Initially used sparingly 1-4 times per day and then frequency is tapered when control is achieved. Shampoos: once a day to once a week (leave on 10 mins). ยท topical ยท q6-24h ยท < 2 months
์ฉ๋์ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์ฐธ๊ณ ์๋ฃ์ ๋๋ค. ํญ์ ์ต์ ๋ผ๋ฒจ๊ณผ ๊ฐ๋ณ ํ์์ ๋ํด ํ์ธํ์ญ์์ค.
ํฌ์ฌ ๊ฒฝ๋ก
๊ธ๊ธฐ
- Tuberculosis of the skin
- Pregnancy (relative contraindication)
- Pregnant animals
- Renal disease (systemic use generally contraindicated)
- Diabetes mellitus (systemic use generally contraindicated)
์ด์๋ฐ์
- Skin atrophy (with long-term use)
- Skin fragility
- Superficial follicular cysts (milia)
- Comedones
- HPA axis suppression (rare, but possible with long-term use)
- Weight loss (catabolic effect)
- Cutaneous atrophy
- Iatrogenic hyperadrenocorticism (PU/PD, elevated liver enzymes)
- Vomiting
- Diarrhoea
- Gastrointestinal ulceration
- Increased urine glucose levels
- Decreased serum T3 and T4 values
- Hypothalamic-pituitary axis suppression (with prolonged use)
- Adrenal atrophy
- Impaired wound healing
์ฝ๋ฌผ ์ํธ์์ฉ
- NSAIDs ยท Increased risk of gastrointestinal ulceration ยท major
- Insulin ยท Glucocorticoids antagonize the effect of insulin ยท major
- Phenobarbital ยท May accelerate the metabolism of corticosteroids ยท moderate
- Itraconazole ยท May decrease the metabolism of corticosteroids ยท moderate
- Acetazolamide ยท Increased risk of hypokalaemia ยท moderate
- Amphotericin B ยท Increased risk of hypokalaemia ยท major
- Furosemide ยท Increased risk of hypokalaemia ยท moderate
- Thiazide diuretics ยท Increased risk of hypokalaemia ยท moderate
๋ชจ๋ํฐ๋ง
- Resolution of clinical signs (pruritus, erythema)
- Signs of skin atrophy or secondary infection
- Serum electrolytes (especially Sodium and Potassium)
- Liver enzymes
- Blood and urine glucose
- Clinical signs of GI ulceration
- Thyroid panel (T3, T4) if indicated
๊ณผ์ฉ๋
Overdose via topical application is unlikely, but chronic overuse can lead to iatrogenic hyperadrenocorticism (Cushing's syndrome) and HPA axis suppression.
VetSheet ์ฝ๋ฌผ ๋ ํผ๋ฐ์ค๋ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์์ฌ๊ฒฐ์ ๋ณด์กฐ ๋๊ตฌ์ด๋ฉฐ, ์ ๋ฌธ์ ํ๋จ์ด๋ ์ ์กฐ์ฌ์ ์ต์ ๋ผ๋ฒจ์ ๋์ ํ์ง ์์ต๋๋ค.