히드록시진

동물 종별 용량

투여 경로

금기

• Hypersensitivity to hydroxyzine or its metabolites (e.g., cetirizine)
• Known hypersensitivity to hydroxyzine or cetirizine
• Early pregnancy (teratogenic in some animal models)

이상반응

• Sedation (most common, usually mild and transient in dogs)
• Hyperexcitability (occasional paradoxical reaction)
• Fine rapid tremors (dogs)
• Whole body tremors (dogs)
• Seizures (rare in dogs)
• Polydipsia (cats)
• Depression (cats)
• Behavioral changes (cats)
• Sedation / Lethargy
• Dry mouth
• Urinary retention
• Gastrointestinal upset
• Paradoxical excitation (rare)

약물 상호작용

• Anticholinergic agents · Additive anticholinergic effects may occur when used concomitantly. · moderate
• CNS Depressant Drugs (e.g., barbiturates, tranquilizers) · Additive CNS depression may be seen.
• Epinephrine · Hydroxyzine may inhibit or reverse the vasopressor effects of epinephrine; use norepinephrine or metaraminol instead.
• CNS Depressants (e.g., opioids, barbiturates, gabapentin) · Additive CNS depression and sedation · major

모니터링

• Efficacy (reduction in pruritus or clinical signs)
• Adverse effects (degree of sedation, excitability, or behavioral changes)
• Resolution of pruritus or allergic signs
• Degree of sedation
• Adverse anticholinergic effects (e.g., monitoring urination)

과용량

Overdoses would be expected to cause **increased sedation** and perhaps **hypotension**. At high doses, fine rapid tremors and rarely seizures have been reported. Common clinical signs of toxicity in dogs include: * Hyperthermia * Lethargy * Tachycardia * Trembling / Tremors * Ataxia * Somnolence **Treatment**: There are no specific antidotes available. Gut emptying protocols should be considered with large or unknown quantity overdoses. Supportive and symptomatic treatment is recommended if necessary.