이바플록사신
Ibafloxacin
다른 이름: Ibaflin · S-25030
VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
동물 종별 용량
🌎 NA — North America🌍 EU — Europe
개
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Susceptible infections (dermal infections: superficial and deep pyoderma, wounds, abscesses) | 15 mg/kg PO once daily | PO | q24h | Usually a 10-day course is sufficient. In cases of deep pyoderma, reconsider treatment if sufficient improvement not seen in 21 days. | 🌎 NA |
- Susceptible infections (dermal infections: superficial and deep pyoderma, wounds, abscesses): Give at time of feeding. Reconsider treatment if no improvement after 5 days.
고양이
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Susceptible infections (dermal infections: soft tissue infections-wounds, abscesses; upper respiratory tract infections) | 15 mg/kg PO once daily | PO | q24h | Usually a 10-day course is sufficient. | 🌎 NA |
- Susceptible infections (dermal infections: soft tissue infections-wounds, abscesses; upper respiratory tract infections): Give at time of feeding. Reconsider treatment if no improvement after 5 days.
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
개요
이바플록사신은 주로 유럽에서 사용되는 수의학 전용 경구용 플루오로퀴놀론계 항생제입니다(미국 미승인). 그람 음성균 및 일부 그람 양성균(장내세균과, 포도상구균 등)에 대해 농도 의존적 살균 효과를 나타냅니다.
임상 요점: 다른 플루오로퀴놀론계(엔로플록사신, 마보플록사신 등)와 달리 녹농균, 연쇄상구균, 프로테우스 미라빌리스에 대한 효과는 떨어집니다.
고양이에서 망막 독성을 유발한다는 보고가 없다는 점은 이 계열의 다른 약물에 비해 큰 장점입니다.
작용 기전
Fluoroquinolones exert their bactericidal effect by targeting essential bacterial enzymes involved in DNA replication and transcription.
- Primary Target: Inhibits bacterial DNA-gyrase (topoisomerase II) → prevents DNA supercoiling → halts DNA synthesis.
- Secondary Target: Inhibits topoisomerase IV → interferes with the separation of interlinked replicated DNA molecules.
Ibafloxacin is metabolized into two active metabolites (8-hydroxy-ibafloxacin and 7-hydroxy-ibafloxacin), which contribute to its overall antimicrobial efficacy.
안전성·주의사항
금기사항
- Dogs less than 8 months of age
- Giant breed dogs less than 18 months of age
- Cats less than 8 months of age
- Known quinolone hypersensitivity
부작용
- Diarrhea
- Soft feces
- Vomiting
- Dullness
- Anorexia
- Salivation
- Elevated hepatic enzymes (rare, class effect)
- Ataxia (rare, class effect)
- Seizures (rare, class effect)
- Depression/Lethargy (rare, class effect)
- Nervousness (rare, class effect)
주의
Use should be based upon susceptibility testing. Safety has not been established in pregnant cats or in lactating dogs and cats, though the UK label states it can be used during pregnancy in dogs. Use with caution in patients with central nervous system disorders.
약물 상호작용
Should not be used with NSAIDs in dogs with a history of seizures due to increased risk of CNS stimulation.
Cations may bind to ibafloxacin and prevent its gastrointestinal absorption.
Fluoroquinolones may exacerbate the nephrotoxicity of systemic cyclosporine.
May antagonize the antimicrobial activity of fluoroquinolones; concomitant use is not recommended.
Increased risk for cardiotoxicity.
May inhibit absorption of ibafloxacin; separate doses by at least 2 hours.
Ibafloxacin may increase theophylline blood levels.
모니터링
- Clinical efficacy
- Adverse GI effects (vomiting, hypersalivation, diarrhea, anorexia)
약동학
반감기
흡수
Dogs: Oral bioavailability is 70-80% with peak levels at ~1.5 hours. Cats: Rapidly absorbed; food slightly delays absorption but doubles peak levels and increases AUC compared to fasted administration.
분포
Dogs: Volume of distribution at steady state is 1.1 L/kg. Goats: Vd is 1.65 L/kg.
대사
Presumably metabolized in the liver to at least two active metabolites: 8-hydroxy-ibafloxacin and 7-hydroxy-ibafloxacin.
배설
Eliminated in both urine and feces as unchanged drug and glucuronidated metabolites. Total clearance in dogs is 8.7 mL/min/kg.
과다투여
Specific information is limited. It is unlikely an acute overdose would result in signs more serious than anorexia or vomiting.
- Dogs: Doses of 75 mg/kg/day (5X) were apparently well tolerated.
- Cats: Doses up to 75 mg/kg/day demonstrated salivation and vomiting. If overdose occurs in cats, ophthalmic monitoring is recommended as a precaution, despite no reported ocular toxicity.
제품
제형
- Oral gel (3%, 7.5%)
- Tablets (30 mg, 150 mg, 300 mg, 900 mg)
동물용의약품
- Ibaflin 3% Oral Gel (30 mg ibafloxacin per gram of gel; 30.9 mg/mL) in 15 mL dial syringes
- 7.5% oral gel
- Tablets: 30 mg, 150 mg, 300 mg, 900 mg
규제 현황
규제 데이터 없음: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
보관·안정성
The oral gel should not be stored at temperatures more than 25°C. Once opened, it is recommended that the syringe be used within 8 weeks. Dispose of unused product once a course of treatment is completed.
보호자 정보
- 투여 방법: 이 약은 식사와 함께 투여하십시오.
- 전체 치료 과정 완료: 반려동물이 다 나은 것처럼 보이더라도 처방된 기간 동안 끝까지 약을 먹여야 합니다. 일찍 중단하면 항생제 내성이 생길 수 있습니다.
- 부작용: 가벼운 위장 장애(구토, 설사, 침 흘림, 식욕 부진)가 있는지 관찰하십시오. 이러한 증상이 심해지거나 지속되면 즉시 수의사에게 연락하십시오.
- 보관 방법: 경구용 겔은 실온(25°C 이하)에 보관하고, 개봉 후 8주가 지난 남은 약은 폐기하십시오.
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