이메피토인

투여 경로

금기

• Severely impaired hepatic function
• Severe renal disorders
• Severe cardiovascular disorders
• Status epilepticus
• Cluster seizures (as primary monotherapy)

이상반응

• Polyphagia
• Hyperactivity
• Polyuria
• Polydipsia
• Somnolence
• Hypersalivation
• Emesis
• Ataxia

약물 상호작용

• Phenobarbital · May have additive CNS depressant effects · moderate
• Other CNS depressants · Additive sedation and CNS depression · moderate

모니터링

• Seizure frequency and severity
• Routine blood work (CBC, serum biochemistry) periodically

과용량

Overdosage is generally well tolerated up to 5 times the recommended dose. Clinical signs of overdose may include severe **ataxia**, **somnolence**, **salivation**, and **vomiting**. **Clinical Pearl:** Treatment is largely supportive and symptomatic, as there is no specific antidote. Due to its rapid elimination, signs usually resolve quickly once the drug is discontinued or metabolized.