이남리논

강심제

이남리논(과거 암리논)은 **비피리딘계 강심제**이자 혈관 확장제입니다. - 울혈성 심부전(CHF)의 단기 관리를 위한 **2차 약물**입니다. - 매우 고가이며 집중적인 모니터링이 필요합니다. > **임상 팁:** 항부정맥제인 아미오다론(amiodarone)과의 혼동으로 인한 치명적인 투약 오류를 방지하기 위해 약물 이름이 암리논에서 이남리논으로 변경되었습니다.

작용 기전: Inamrinone acts primarily as a **phosphodiesterase III (PDE3) inhibitor**. - **Inhibition of PDE3** → decreased breakdown of intracellular cyclic AMP (cAMP) → increased intracellular calcium in the myocardium → **positive inotropy** (direct stimulation of cardiac contractility). - In vascular smooth muscle, increased cAMP leads to relaxation → **vasodilation**, which effectively reduces both cardiac preload and afterload.

동물 종별 용량

Cats

Positive inotropic agent · 1-3 mg/kg IV followed by 30-100 micro-grams/kg/min IV infusion · IV · CRI
Positive inotropic agent · 1-3 mg/kg IV as a slow IV bolus followed by a 10-100 micrograms/kg/min IV CRI; ½ the initial bolus may be administered 20-30 minutes after the first bolus. · IV · CRI

Dogs

Positive inotropic agent · 1-3 mg/kg IV as a slow IV bolus followed by a 10-100 micrograms/kg/min IV CRI; ½ the initial bolus may be administered 20-30 minutes after the first bolus. · IV · CRI
Positive inotropic agent · 1-3 mg/kg IV followed by a 30-100 micrograms/kg/min IV CRI · IV · CRI
Positive inotropic agent · 2 mg/kg bolus IV , followed by 30-300 micrograms/kg/min IV infusion · IV · CRI
For patients coming off cardiopulmonary bypass with poor cardiac contractility · 0.25-0.6 mg/kg loading, then 5-45 micrograms/kg/min CRI · IV · CRI
Adjunctive treatment for calcium channel blocker overdose · 30-100 micrograms/kg/min CRI. · IV · CRI · Alternative to dopamine or dobutamine; used with fluids, IV calcium, and potentially glucagon.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

Severe aortic or pulmonic valve disease
Hypersensitivity to inamrinone or bisulfites

이상반응

Arrhythmias
Hypotension
Vomiting
Diarrhea
Thrombocytopenia (particularly with prolonged therapy)
Hepatotoxicity
Hypersensitivity reactions (variable symptomatology: pericarditis to myositis)

약물 상호작용

Digoxin · Additive inotropic effect; generally considered a positive drug interaction.
Disopyramide · May cause excessive hypotension when used concurrently.

모니터링

Blood pressure
Heart rate/rhythm (continuous ECG recommended)
Body weight
Platelet counts

과용량

Because **hypotension** is the primary problem that would generally be seen, circulatory support should be instituted immediately. Only one human case of accidental massive overdose resulting in death has been reported (causal relationship not unequivocally established).

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.