인터페론 오메가

면역조절제 / 항바이러스 사이토카인

인터페론 오메가는 고양이 유래의 재조합 **제1형 인터페론**으로, 강력한 면역조절 및 항바이러스 효과를 지닙니다. * **수의학적 용도**: 주로 **개 파보바이러스** 및 고양이 레트로바이러스(**FeLV 및 FIV**)와 같은 중증 바이러스 감염 치료에 사용됩니다. * **교차 종 효능**: **임상 요점:** 고양이 유래 단백질이지만, 제1형 인터페론은 종간 수용체 친화성을 공유하므로 개에게도 매우 효과적입니다. 단, 개에게 장기간 사용할 경우 중화 항체가 형성될 수 있습니다. * **새로운 용도**: 개 아토피 피부염, 고양이 전염성 복막염(FIP), 고양이 칼리시바이러스(FCV), 고양이 헤르페스바이러스(FHV-1) 피부염 또는 각막염 치료에 잠재적인 이점이 있는 것으로 나타났습니다. * **구입 가능성**: EU 및 기타 지역에서는 상업적으로 판매되지만, 미국에서는 시판되지 않습니다(동정적 사용을 위한 합법적 수입 필요).

작용 기전: Interferon-omega does not act as a direct virucidal agent. Instead, it induces an antiviral state in host cells: 1. **Receptor Binding**: Binds to specific type I interferon receptors on the surface of target cells. 2. **Signal Transduction**: Activates the **JAK-STAT signaling pathway**. 3. **Gene Transcription**: Induces the transcription of interferon-stimulated genes (ISGs). 4. **Antiviral Proteins**: Leads to the production of key enzymes such as **2'-5' oligoadenylate synthetase (OAS)** and **protein kinase R (PKR)**. 5. **Viral Inhibition**: These enzymes inhibit viral mRNA translation and degrade viral RNA → effectively halting viral replication. Additionally, it nonspecifically enhances host immune defense mechanisms by stimulating natural killer (NK) cells and macrophages.

동물 종별 용량

Cats

Treatment of FeLV and/or FIV (non-terminal clinical stages) · 1 million Units/kg SC once daily · SC · q24h · 5 days (Three separate 5-day treatments performed at day 0, day 14, and day 60)
FHV-1 facial dermatitis · Day 0: 1.5 million Units/kg (half peri-lesionally/intradermally, half SC). Day 2 and 9: 1.5 million Units/kg SC. Days 19, 21, and 23: 0.75 million Units/kg peri-lesionally/intradermally + 0.75 million Units/kg SC. · SC / Intradermal / Peri-lesional · Specific days · 23 days · Cat was sedated with propofol for peri-lesional and intradermal injections.

Dogs

Treatment of parvovirus (enteric form) · 2.5 million Units/kg IV once daily · IV · q24h · 3 days · The earlier the dog is treated, the more likely of success.
Treatment of atopic dermatitis · Dogs 8-15 kg = 1 million Units; 15-29 kg = 2 million Units; 29-40 kg = 3 million Units; >40 kg = 4 million Units · SC · Specific days · Days 0, 3, 7, 14, 21, 35, 56, 90, 120, & 150 · Further larger-scale studies needed to confirm cost-effectiveness and safety for long-term treatment.
Parvovirus · 2.5 million units/kg · IV · q24h · 3 days

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

IVSCIntradermalPeri-lesionalTopical (ophthalmic - off-label)Topical

금기

Concurrent vaccination in dogs (wait until fully recovered)
Vaccination in cats during and after treatment (due to the immunosuppressive nature of FeLV/FIV)
Substitution with human interferons (alpha, beta, or gamma)
No specific contraindications available in the monograph

이상반응

Hyperthermia (typically 3-6 hours post-dose)
Vomiting
Soft feces or mild diarrhea (cats)
Transient fatigue or lethargy (cats)
Slight decreases in RBCs, WBCs, and platelets (usually resolves within a week)
Increased ALT (usually resolves within a week)
Antibody formation in dogs (with prolonged or repeated treatment)
Transient fatigue
Hyperthermia
Mild diarrhoea
Decreased WBCs (leukopenia)
Decreased platelets (thrombocytopenia)
Decreased RBCs (anaemia)
Increased liver enzyme activities
Ocular irritation (with topical use in cats)
Immune-mediated diseases (reported with long-term administration in humans)

약물 상호작용

Hepatotoxic drugs · May increase the risk of liver toxicity; use with caution.
Myelosuppressive drugs · May increase the risk of bone marrow suppression; use with caution.
Vaccines · Should not be administered concurrently until the animal has clinically recovered. · major
Antibiotics · Improves prognosis; no negative interactions observed. · null
NSAIDs · Improves prognosis; no negative interactions observed. · null

모니터링

Clinical efficacy (resolution of viral infection signs)
Complete Blood Count (CBC) to monitor for myelosuppression
Hepatic function tests (ALT)
Complete Blood Count (WBCs, RBCs, platelets)
Liver enzyme activities
Body temperature
Clinical signs of gastrointestinal upset or fatigue

과용량

In safety studies, 10X overdoses in dogs and cats caused mild lethargy/somnolence, slight hyperthermia, and slight increases in respiratory and heart rates. In all animals tested, clinical signs resolved within 7 days and no specific treatment was required.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.