지방 유제

영양 보충제 / 해독제

정맥주사용 지방 유제(ILE)는 주로 **정맥 영양**을 통해 고밀도 칼로리와 필수 지방산을 공급하는 데 사용됩니다. 수의 응급 의학에서는 지용성 약물(예: 아버멕틴류, 부피바카인과 같은 국소 마취제) 중독에 대한 **해독제**로 점점 더 많이 사용되고 있습니다. > **임상 경고:** 인슐린 저항성(예: 당뇨병)이 있거나 췌장염 위험이 있는 환자에게는 극도로 주의하여 사용해야 합니다. 유제는 미생물 증식을 강력히 촉진하므로 엄격한 무균 조작이 필수적입니다. **임상 팁:** 중독 치료를 위한 ILE 사용은 종종 '지방 구조(Lipid Rescue)' 요법으로 불립니다.

작용 기전: As a nutritional supplement, lipid emulsions provide **triglycerides** which are hydrolyzed by **lipoprotein lipase** into free fatty acids and glycerol, entering cellular metabolism via **beta-oxidation** to produce ATP. As an antidote, the primary mechanism is the **'lipid sink' theory**: the infusion creates an expanded intravascular lipid phase that sequesters highly lipophilic toxins (e.g., bupivacaine, ivermectin) away from target organs (brain, heart) → reducing clinical toxicity.

동물 종별 용량

Dogs

Parenteral nutrition · Supply 30% (partial peripheral) to 40-60% of energy requirements · IV · continuous · As required · Amount governed by physiological status
Treatment of lipid-soluble toxicosis (e.g., ivermectin, moxidectin) · 1.5-5 ml/kg of 20% lipid solution as bolus, followed by 0.25-0.50 ml/kg/min infusion. Boluses of 1.5 ml/kg can be repeated. · IV · bolus followed by continuous infusion · Infusion for 30-60 min (maximum 24 hours) · Infusions of 0.5 ml/kg/min can be administered for a maximum of 24 hours.

Cats

Parenteral nutrition · Supply 40-60% of energy requirements · IV · continuous · As required · Generally used as an energy source in a nutrient admixture for infusion through central venous access (total parenteral nutrition).
Treatment of lipid-soluble toxicosis (e.g., ivermectin, moxidectin) · 1.5-5 ml/kg of 20% lipid solution as bolus, followed by 0.25-0.50 ml/kg/min infusion. Boluses of 1.5 ml/kg can be repeated. · IV · bolus followed by continuous infusion · Infusion for 30-60 min (maximum 24 hours) · Infusions of 0.5 ml/kg/min can be administered for a maximum of 24 hours.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

Insulin resistance (e.g., diabetes mellitus)
Hyperlipidaemia
Disrupted fat metabolism

이상반응

Febrile episodes (mainly with 20% emulsions)
Vasculitis
Thrombosis
Anaphylaxis (rare)
Hepatic failure (with prolonged treatment)
Pancreatitis (with prolonged treatment)
Cardiac arrest (with prolonged treatment)
Thrombocytopenia (with prolonged treatment)

약물 상호작용

Other IV medications · Physical incompatibility; requires dedicated IV line for parenteral feeding · major
Biochemical assays · Lipaemia interferes with blood gas and calcium measurements if samples are taken before fat is cleared · moderate

모니터링

Plasma clearance (visual lipaemia or serum triglycerides daily)
Blood glucose
Pancreatic enzymes
Coagulation profile (if prolonged use)

과용량

Overdosage or failure to clear lipids can lead to **fat overload syndrome**, characterized by hyperlipidaemia, fever, jaundice, hepatosplenomegaly, and coagulopathy. Treatment involves immediate cessation of the infusion and supportive care.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.