리튬

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Cats (highly toxic)
• Renal impairment
• Cardiac disease
• Conditions with sodium imbalance (e.g., hypoadrenocorticism)
• Dehydration

이상반응

• Nausea
• Diarrhoea
• Muscle weakness
• Fatigue
• Polyuria (PU)
• Polydipsia (PD)
• Seizures
• Hypothyroidism (blocks release of T3 and T4)

약물 상호작용

• ACE inhibitors · Reduces lithium excretion, increasing the risk of toxicity · major
• Loop diuretics · Reduces lithium excretion and causes sodium depletion, worsening toxicity · major
• Thiazide diuretics · Reduces lithium excretion and causes sodium depletion, worsening toxicity · major
• NSAIDs · Reduces lithium excretion, increasing the risk of toxicity · major
• Theophylline · May increase the excretion of lithium, potentially reducing efficacy · moderate
• Neostigmine · Lithium antagonizes the effects of neostigmine · moderate
• Pyridostigmine · Lithium antagonizes the effects of pyridostigmine · moderate
• Diltiazem · Concurrent administration may result in neurotoxicity · major
• Verapamil · Concurrent administration may result in neurotoxicity · major

모니터링

• Serum lithium concentration (target 0.5-1.8 mmol/l, assess every 3 months)
• Thyroid status (T3 and T4, assess every 6 months)
• Renal function
• Hydration status and serum sodium levels

과용량

Lithium is **nephrotoxic at high doses**. Toxicity is significantly worsened by sodium depletion (e.g., concurrent diuretic use or dehydration). Signs of toxicity may include severe nausea, diarrhoea, muscle weakness, polyuria/polydipsia, and seizures.