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수산화마그네슘

Magnesium Hydroxide

Magnesium hydroxide

제산제 / 하제PO개고양이말소양염소

다른 이름: Milk of Magnesia · Magnalax · Carmilax · Polymag · Rumen Bolus · Instamag · Polyox · Laxade · Maalox · Phillips' Chewable · Magnesium/Aluminum Antacids

VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료

5-15 mL/per dog per 24 hoursPO· q24h
5–15 ml — 개체당 고정 용량(체중에 따라 환산하지 않음)

용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.

동물 종별 용량

🌎 NA — North America🌍 EU — Europe

개

적응증용량경로빈도기간지역
Adjunctive treatment of hypomagnesemia with GI disease and severe hypocalcemia5-15 mL/per dog per 24 hoursPOq24h—🌎 NA
Adjunctive therapy for gastric ulcers2-10 mL PO q2-4hPOq2-4h—🌎 NA
Antacid5-30 mL PO once to twice dailyPOq12-24h—🌎 NA
  • Adjunctive treatment of hypomagnesemia with GI disease and severe hypocalcemia: Using Milk of Magnesia
  • Adjunctive therapy for gastric ulcers: Using Aluminum hydroxide suspension or aluminum hydroxide/magnesium hydroxide suspension
  • Antacid: Using Milk of Magnesia

고양이

적응증용량경로빈도기간지역
Antacid5-15 mL PO once to twice dailyPOq12-24h—🌎 NA
  • Antacid: Using Milk of Magnesia

말

적응증용량경로빈도기간지역
Adjunctive gastroduodenal ulcer therapy in foals15 mL 4 times a dayPOq6h—🌎 NA
  • Adjunctive gastroduodenal ulcer therapy in foals: Using Aluminum/magnesium hydroxide suspension

소

적응증용량경로빈도기간지역
Rumen overload syndrome (Adults)Up to 1 gram/kg (MgOH) mixed in 2-3 gallons of warm water and given PO per tube. May repeat (use smaller doses) at 612 hour intervals. If the rumen has been evacuated, do not exceed 225 grams initially.POq6-12h—🌎 NA
Rumen overload syndrome (Calves)As above but use ⅛th-¼th the amountPOq6-12h—🌎 NA
  • Rumen overload syndrome (Adults): Dehydration and systemic acidosis must be concomitantly corrected.

양

적응증용량경로빈도기간지역
Rumen overload syndromeAs above for cattle, but use ⅛th-¼th the amountPOq6-12h—🌎 NA

염소

적응증용량경로빈도기간지역
Rumen overload syndromeAs above for cattle, but use ⅛th-¼th the amountPOq6-12h—🌎 NA

용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.

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개요

수산화마그네슘은 수의학에서 경구용 제산제 및 하제로 사용됩니다. 소동물에서는 위산 과다 및 궤양 치료에 사용되었으나 현재는 더 효과적인 약물로 대체되었습니다. 반추동물에서는 제1위 과부하 증후군(제1위 산증) 치료에 분말 형태가 매우 효과적입니다.

작용 기전

Acts locally in the gastrointestinal tract:

  • Antacid: Neutralizes gastric hydrochloric acid (HCl) → raises gastric pH. Raising pH >4 minimizes pepsin proteolytic activity, reducing gastric mucosal damage.
  • Laxative: Poorly absorbed magnesium ions create an osmotic gradient → draws water into the intestinal lumen → distends the bowel → stimulates peristalsis.
  • Rumen Alkalinizer: Directly neutralizes excess lactic acid produced during grain overload → increases rumen pH and alters rumen microflora activity.

안전성·주의사항

금기사항

  • Renal disease (due to risk of hypermagnesemia)
  • Gastric outlet obstruction (for aluminum-containing products)
  • Use cautiously in patients on sodium- or potassium-restricted diets (some products contain significant amounts)

부작용

  • Diarrhea or frequent loose stools
  • Hypermagnesemia (especially in patients with severe renal insufficiency)
  • Constipation (if using combination products with aluminum)
  • Hypophosphatemia (with chronic use of aluminum-containing products)

주의

Magnesium-containing antacids are contraindicated in patients with renal disease. Oral magnesium hydroxide should only be used clinically in ruminants with documented rumen acidosis and should not be used for treatment of other suspected rumen disorders or hypomagnesemia. Chronic use may lead to electrolyte abnormalities.

약물 상호작용

Quinidine

Increased absorption or pharmacologic effect may occur

Sodium Polystyrene Sulfonate

May decrease the potassium-lowering effectiveness; may cause metabolic alkalosis in renal failure patients

Sustained-release medications

May alter absorption by changing GI transit times when used at laxative dosages

Sympathomimetic agents

Increased absorption or pharmacologic effect may occur

Fluoroquinolones

Decreased absorption (chelation); separate doses by at least 2 hours

Tetracyclines

Decreased absorption (chelation); separate doses by at least 2 hours

Azole Antifungals (Ketoconazole, Itraconazole)

Decreased absorption due to increased gastric pH; separate doses by at least 2 hours

Digoxin

Decreased absorption; separate doses by at least 2 hours

Iron Salts

Decreased absorption; separate doses by at least 2 hours

H-2 Antagonists

Decreased absorption; separate doses by at least 2 hours

Thyroid Hormones

Decreased absorption; separate doses by at least 2 hours

Corticosteroids

Decreased absorption; separate doses by at least 2 hours

Phenothiazines

Decreased absorption; separate doses by at least 2 hours

모니터링

  • Electrolyte imbalances (Magnesium, Phosphorus, Calcium) with chronic or high-dose therapy
  • Renal function
  • Fecal consistency

약동학

흡수

Generally relatively non-absorbable, but up to 20% of an oral dose of magnesium can be absorbed.

배설

Absorbed magnesium is excreted by the kidneys.

과다투여

Chronic or acute overdose can lead to significant GI upset (severe diarrhea) and electrolyte imbalances (hypermagnesemia, especially in renal failure). Treat symptomatically with fluid therapy and correct electrolyte derangements.

제품

제형

  • Oral Boluses
  • Oral Powder
  • Oral Liquid (Milk of Magnesia)
  • Chewable Tablets
  • Oral Suspension

동물용의약품

  • Oral Boluses 17.9-27 grams (Magnalax, Carmilax, Polymag, Rumen Bolus, Instamag, Polyox II, Laxade)
  • Oral Powder 350-361 grams/lb (Carmilax Powder, Magnalax, Polyox, Laxade)
  • Milk of Magnesia 80 mg/mL in gallons

인용의약품

  • Chewable Tablets: 311 mg & 400 mg (Phillips' Chewable, Pedia-Lax)
  • Oral Liquid (Milk of Magnesia): 400 mg/5 mL
  • Liquid concentrate: 800 mg/5 mL & 1,200 mg/5 mL
  • Aluminum Hydroxide and Magnesium Hydroxide Suspension (e.g., Maalox)

규제 현황

규제 데이터 없음: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

보관·안정성

Store at room temperature in tight containers.

보호자 정보

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