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λ©λλ‘μνλ‘κ²μ€ν λ‘ μμΈν μ΄νΈ(MPA)λ νλ‘κ²μ€ν λ‘ μ κ°λ ₯ν ν©μ± **νλ‘κ²μ€ν΄** μ λ체μ λλ€. κ³Όκ±° μμνμμλ νλ κ΅μ (μ: λ°°ν, μμ»· κ°μ 곡격μ±, μ€νλ μ΄ νλ) λ° νΌλΆ μ§ν(μ: κ³ μμ΄ μ¬μΈμ± νλͺ¨μ¦)μ μ¬μ©λμμ΅λλ€. κ·Έλ¬λ **μ¬κ°ν λΆμμ© λ°μ μνμ΄ λμ** νμ¬λ κ·Έ μ¬μ©μ΄ ν¬κ² κ°μνμ΅λλ€. **μμ μμ :** νλ λ¬Έμ μ κ²½μ° λ μμ ν λμ(μ: SSRI, TCA λλ μΈκ³Όμ μ€μ±ν)μ΄ κ°λ ₯ν κΆμ₯λ©λλ€. MPAλ μμ ν μκ°μ ν©μ²΄ κΈ°λ₯ λΆμ , μμ± μ 립μ λΉλμ¦μ λ¨κΈ° κ΄λ¦¬ λλ μ λ¨Ό μ °νΌλμ λνμμ²΄μ± μμΈμ¦κ³Ό κ°μ νΉμ μμκΈ°κ³ μ μμ¦μ μ¬μ ν κ°νΉ μ¬μ©λ©λλ€. μ μ μ λ―ΈμΉλ μν₯μ΄ ν¬κΈ° λλ¬Έμ, λ΄λΆλΉ λ° μμκΈ°κ³ ν©λ³μ¦μ μ€λν μνκ³Ό μ μ¬μ μ΄μ μ μ μ€νκ² μ μΈμ§ν΄μΌ ν©λλ€.
μμ© κΈ°μ : MPA mimics endogenous progesterone by binding to intracellular **progesterone receptors**, translocating to the nucleus, and altering gene transcription. It transforms the proliferative endometrium into a secretory endometrium and inhibits spontaneous uterine contractions. * **Endocrine/Reproductive:** Exerts negative feedback on the hypothalamus and pituitary, decreasing **GnRH** β suppressing **FSH** and **LH** release, thereby inhibiting estrus and spermatogenesis. It also possesses anti-estrogenic properties and decreases plasma testosterone. * **Glucocorticoid Activity:** MPA has significant intrinsic affinity for **glucocorticoid receptors**, leading to profound suppression of the hypothalamic-pituitary-adrenal (HPA) axis (decreased ACTH and cortisol release). * **Metabolic Effects:** Induces peripheral insulin resistance, which can precipitate **diabetes mellitus**. * **Growth Hormone:** In dogs, progestins can stimulate the mammary glands to produce growth hormone, potentially leading to acromegaly.
λλ¬Ό μ’ λ³ μ©λ
- Behavioral disorders (reduce marking in neutered males) Β· 5-20 mg/kg SC or IM three to four times yearly Β· SC/IM Β· 3-4 times yearly Β· Use when all other drugs have been unsuccessful.
- Feline psychogenic alopecia and dermatitis Β· 75-150 mg IM or SC Β· IM/SC Β· Repeat as necessary, but never more often than every 2-3 months
- Progestagen-responsive dermatitis Β· 50-100 mg IM Β· IM Β· May repeat in 3-6 months if needed
- Recurrent abortion secondary to progesterone-deficiency Β· 1-2 mg/kg IM once weekly Β· IM Β· q7d Β· Stop treatment 7-10 days prior to parturition
- Long-term reproductive control Β· 2.5-5 mg PO once weekly; 25 mg injected every 6 months to postpone estrus Β· PO/IM/SC Β· q7d (PO) or q6mo (Injection)
- Long-term reproductive control Β· 2 mg/kg IM q5 months Β· IM Β· q5 months
- Management of spring transition, prevention of estrus behavior, induction of estrous cycle synchrony, pregnancy maintenance, modification of stallion behavior Β· 500 to 800 mg IM Β· IM Β· Interval varies Β· Most injections last 2 to 3 months Β· Will not prevent pregnancy loss and does not stop cyclicity.
- Antipruritic and to suppress ovulation Β· 0.025-1 mL (3 mg/100 grams body weight) IM once every 4-6 weeks Β· IM Β· q4-6w Β· May cause obesity, fatty liver, polydipsia/polyuria and lethargy if used repeatedly.
ν¬μ¬ κ²½λ‘
κΈκΈ°
- Pre-pubescent cats or dogs
- Diabetes mellitus
- Pseudopregnant bitches
- Females in diestrus or with prolonged heat
- Uterine hemorrhage or discharge
- Pregnancy (unless specifically treating hypoluteoidism)
μ΄μλ°μ
- Increased thirst (polydipsia) and urination (polyuria)
- Increased appetite (polyphagia) and weight gain
- Depression, lethargy, and personality changes
- Adrenocortical depression (HPA axis suppression)
- Mammary changes (enlargement, milk production, neoplasia)
- Diabetes mellitus
- Pyometra / Cystic endometrial hyperplasia
- Temporary inhibition of spermatogenesis
- Permanent local alopecia, skin atrophy, and depigmentation (with SC injection)
- Acromegaly (in dogs)
μ½λ¬Ό μνΈμμ©
- Aminoglutethimide Β· May decrease medroxyprogesterone effects
- Felbamate Β· May increase medroxyprogesterone metabolism
- Rifampin Β· May decrease progestin activity due to microsomal enzyme induction and increased progestin metabolism
λͺ¨λν°λ§
- Weight
- Blood glucose (draw baseline before therapy and monitor periodically)
- Mammary gland development
- Adrenocortical function
- Clinical efficacy
κ³Όμ©λ
No specific reports on inadvertent acute overdosage were located. Overdose is expected to manifest as an exaggeration of adverse effects, including profound adrenal suppression, lethargy, metabolic derangements (hyperglycemia), and reproductive tract changes. Treatment should be supportive and symptomatic.
VetSheet μ½λ¬Ό λ νΌλ°μ€λ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μμ¬κ²°μ 보쑰 λꡬμ΄λ©°, μ λ¬Έμ νλ¨μ΄λ μ μ‘°μ¬μ μ΅μ λΌλ²¨μ λμ νμ§ μμ΅λλ€.