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멜록시캄

Meloxicam

4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide

비스테로이드성 항염증제 (NSAID)POSCIVTransmucosal개고양이소형 포유류페렛새파충류말소돼지

다른 이름: Metacam · Meloxidyl · Loxicom · Mobic · Orocam · Rheumocam · Inflacam · Meloxivet · Meloxicamum

VetSheet 수의사 팀 검수업데이트 2026년 6월 3일근거 기반 수의학 참고자료

감사 완료 v13 용량 근거

구조화 용량 계산 근거

Analgesia during gastrointestinal stasis

1 mg/kgSCPO

인증된 수의사 확인 필요

  • q24h
반드시 함께 고려할 임상 맥락 (2)
  • Exclude emergent diagnoses (obstruction, enterotoxemia)
  • if renal status stable
고위험인증된 수의사 확인 필요textbook프로토콜 2021감사 dose-audit-v13

용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.

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개요

​멜록시캄(Meloxicam)​은 옥시캄 계열에 속하는 널리 사용되는 ​비스테로이드성 항염증제(NSAID)​입니다. 수의학에서는 주로 골관절염과 관련된 통증 및 염증 관리, 그리고 수술 후 통증 조절을 위해 처방됩니다.

주요 특성은 다음과 같습니다:

  • ​진통 효과:​ 통증 인지를 감소시킵니다.
  • ​항염 효과:​ 조직의 염증을 줄입니다.
  • ​해열 효과:​ 열을 내립니다.

​임상 요점:​ 멜록시캄은 1일 1회 투여의 편리함과 기호성이 높은 경구용 현탁액 형태로 제공되어 환자의 정확한 체중에 맞춘 정밀한 용량 조절이 가능하기 때문에 소동물 임상에서 매우 선호됩니다.

작용 기전

Meloxicam exerts its therapeutic effects primarily through the ​inhibition of cyclooxygenase (COX)​ enzymes, which are responsible for synthesizing prostaglandins from arachidonic acid.

Arachidonic Acid → COX Enzymes → Prostaglandins & Thromboxanes

  • ​COX-1 (Constitutive):​ Produces prostaglandins that protect the gastric mucosa, maintain normal renal blood flow, and support platelet function.
  • ​COX-2 (Inducible):​ Upregulated in response to tissue injury and inflammation, producing pro-inflammatory prostaglandins.

Meloxicam is a COX-2 preferential (or COX-2 selective) NSAID at therapeutic doses. This means it preferentially inhibits the COX-2 enzyme, thereby reducing inflammation and pain, while largely sparing the COX-1 enzyme, which theoretically reduces the risk of gastrointestinal and renal side effects compared to non-selective NSAIDs.

안전성·주의사항

금기사항

  • Patients with known hypersensitivity to meloxicam or other NSAIDs
  • Active gastrointestinal ulceration or bleeding
  • Pre-existing renal, hepatic, or cardiovascular dysfunction
  • Hypovolemic, dehydrated, or hypotensive patients (increased risk of renal toxicity)
  • Concurrent use of other NSAIDs or corticosteroids
  • Bleeding disorders
  • Impaired hepatic, cardiac, or renal function
  • Hemorrhagic disorders
  • Hypersensitivity to NSAIDs
  • Dehydrated, hypovolemic, or hypotensive animals

부작용

  • Gastrointestinal upset (vomiting, diarrhea, inappetence)
  • Gastrointestinal ulceration or bleeding (melena, hematemesis)
  • Renal toxicity (elevated BUN/Creatinine, acute kidney injury)
  • Hepatic toxicity (elevated ALT/AST, rare but possible)
  • Lethargy or depression
  • Renal impairment
  • Hepatic enzyme elevation

주의

​Important Precautions:​

  • ​Hydration Status:​ Ensure patients are well-hydrated and normotensive prior to administration, especially perioperatively, to mitigate the risk of ischemic renal injury.
  • ​Feline Use:​ In the United States, meloxicam carries a Black Box Warning for cats regarding repeated oral dosing, which has been associated with acute renal failure and death. However, single-dose injections for post-operative pain are approved, and off-label highly titrated, low-dose chronic use is practiced in other countries under strict monitoring.
  • ​Washout Periods:​ Implement an appropriate washout period (typically 5-7 days) when transitioning a patient from a corticosteroid or another NSAID to meloxicam.

약물 상호작용

Corticosteroids (e.g., Prednisone, Dexamethasone)

Significantly increases the risk of severe gastrointestinal ulceration and bleeding. Concurrent use is strictly contraindicated.

Other NSAIDs (e.g., Carprofen, Deracoxib)

Additive toxicity; increases risk of GI, renal, and hepatic adverse effects. A washout period is required when switching.

ACE Inhibitors (e.g., Enalapril, Benazepril)

May reduce the efficacy of the ACE inhibitor and increase the risk of renal toxicity.

FurosemideModerate

NSAIDs may reduce the diuretic effect of furosemide.

Anticoagulants (e.g., Heparin, Warfarin)

Increased risk of bleeding complications.

CorticosteroidsMajor

Increased risk of severe gastrointestinal ulceration and bleeding

Other NSAIDsMajor

Increased risk of gastrointestinal and renal toxicity

ACE InhibitorsModerate

Potential reduction in hypotensive effect and increased risk of renal toxicity

모니터링

  • Baseline blood work (CBC, Chemistry panel) prior to initiating chronic therapy
  • Renal values (BUN, Creatinine, SDMA, USG)
  • Hepatic enzymes (ALT, AST, ALP)
  • Clinical signs of GI toxicity (vomiting, diarrhea, melena, anorexia)
  • Hydration status
  • Liver enzymes (ALT, ALP)
  • PCV/TP (if GI bleeding suspected)
  • Clinical signs of GI upset (vomiting, diarrhea, melena)

약동학

반감기

고양이15 hours말8.5 hours개24 hours

흡수

Well absorbed following oral administration. Peak plasma concentrations are typically reached within 2-4 hours in dogs.

분포

Highly protein-bound (>97%). Penetrates synovial fluid, reaching concentrations approximately 40-50% of those in blood plasma.

대사

Extensively metabolized in the liver via cytochrome P450 enzymes (oxidation).

배설

Excreted primarily as metabolites in feces (biliary excretion) and urine.

과다투여

​Overdose Management:​

Overdosage of meloxicam increases the risk of severe gastrointestinal ulceration, acute renal failure, and hepatic toxicity.

  • ​Recent Ingestion (< 2 hours):​ Induce emesis (if no contraindications) followed by the administration of activated charcoal to prevent further absorption.
  • ​Gastrointestinal Protection:​ Initiate GI protectants such as sucralfate, H2-receptor antagonists (e.g., famotidine), or proton pump inhibitors (e.g., omeprazole).
  • ​Renal Protection:​ Administer intravenous fluid therapy (e.g., Lactated Ringer's or 0.9% NaCl) at diuresis rates for 48-72 hours to support renal perfusion and flush the kidneys.
  • ​Monitoring:​ Monitor baseline and daily renal panel (BUN, Creatinine, Phosphorus), PCV/TP, and liver enzymes.

제품

제형

  • Oral suspension (0.5 mg/mL, 1.5 mg/mL)
  • Injectable solution (5 mg/mL)
  • Tablets (1 mg, 2.5 mg, 7.5 mg, 15 mg)
  • Transmucosal oral spray
  • 0.5 mg/ml oral suspension (cats)
  • 1.5 mg/ml oral suspension (dogs)
  • 1.0 mg tablet (dogs)
  • 2.5 mg tablet (dogs)
  • 2 mg/ml injectable solution (cats)

동물용의약품

  • Metacam 1.5 mg/mL Oral Suspension (Dogs)
  • Metacam 0.5 mg/mL Oral Suspension (Cats/Dogs)
  • Metacam 5 mg/mL Injectable Solution
  • Meloxidyl 1.5 mg/mL Oral Suspension
  • Loxicom Oral Suspension
  • Orocam Transmucosal Spray
  • Inflacam
  • Meloxivet
  • Rheumocam

인용의약품

  • Mobic 7.5 mg Tablets
  • Mobic 15 mg Tablets
  • Generic meloxicam tablets and capsules

규제 현황

European Union✓ 승인됨처방전의약품EMA
🐕 Dogs🐈 Cats🐄 Cattle pigs🐴 Horses

투여 중단 기간: pig meat 5 days · cattle meat 15 days · horse meat 5 days

POM-V status in the UK/EU.

United Kingdom✓ 승인됨처방전의약품VMD
🐕 Dogs🐈 Cats🐄 Cattle pigs🐴 Horses

POM-V

규제 데이터 없음: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

보관·안정성

Store at controlled room temperature (20-25°C or 68-77°F). Keep oral suspensions tightly closed. Do not freeze.

보호자 정보

​반려동물 투약에 관한 중요 안내:​

  • ​음식과 함께 투여:​ 위장 장애를 예방하기 위해 멜록시캄은 항상 식사와 함께 또는 식사 직후에 투여하십시오.
  • ​올바른 주사기 사용:​ 액상 형태를 사용하는 경우, 정확한 용량을 투여하기 위해 반드시 약물과 함께 제공된 전용 투약 주사기만 사용하십시오.
  • ​부작용 관찰:​ 다음 중 하나라도 발견되면 즉시 투약을 중단하고 수의사에게 연락하십시오:
    • 구토 또는 설사
    • 검고 끈적거리거나 피가 섞인 변
    • 식욕 상실 또는 식사 거부
    • 무기력, 우울증 또는 평소와 다른 행동
    • 음수량 또는 배뇨량 증가

​심각한 경고:​ 반려동물이 멜록시캄을 복용하는 동안 사람용 진통제(예: 아스피린, 이부프로펜/애드빌, 타이레놀/아세트아미노펜)나 다른 동물용 진통제를 ​절대​ 주지 마십시오. 이러한 약물을 함께 사용하면 치명적인 위궤양이나 신부전을 유발할 수 있습니다.

VetSheet 의약품 참고자료는 수의사 전문가의 임상 의사결정 지원을 위한 것이며, 전문적 판단이나 제조사의 최신 약물 정보를 대체할 수 없습니다.