메테르골린

세로토닌 길항제; 프로락틴 억제제

**메테르골린(Metergoline)**은 수의학에서 주로 반려견의 **상상임신(위임신)**을 관리하는 데 사용되는 **맥각 유도체** 약물입니다. 주요 임상 포인트: - **프로락틴 억제제**로 작용하여 상상임신과 관련된 원치 않는 유즙 분비 및 행동 변화를 중단시킵니다. - 임신 마지막 3주 동안 고용량으로 투여 시 유산 유도제로의 사용이 연구된 바 있습니다. - 미국에서는 상업적으로 판매되지 않으나, 유럽 및 남미에서는 널리 사용됩니다. - 인의학에서는 고프로락틴혈증 및 편두통 예방에 사용됩니다.

작용 기전: Metergoline reduces prolactin secretion primarily through its **serotonin receptor antagonism**. Mechanistic pathway: - **Serotonin (5-HT) antagonism** → Inhibition of prolactin release from the anterior pituitary. - Unlike other prolactin inhibitors (e.g., cabergoline, bromocriptine), it possesses strong central and peripheral anti-serotonin effects. - Exhibits weak direct **dopamine-2 (D2) agonist** effects and acts as an antagonist at **dopamine-1 (D1) receptors**.

동물 종별 용량

Cats

Treatment of pseudopregnancy or to halt post-partum lactation · 0.125 mg/kg PO twice a day · PO · q12h · 4-8 days

Dogs

Treatment of pseudopregnancy · 0.5 mg/kg (500 micrograms/kg) PO twice a day · PO · q12h · 4-5 days · Occasional failures can be dealt with by repeating the treatment protocol and extending it to 8 to 10 days, or by using joint protocols of cabergoline plus metergoline or cabergoline plus bromocriptine.
Treatment of pseudopregnancy · 0.1 mg/kg, PO twice a day · PO · q12h · 8 to 10 days
Treatment of pseudopregnancy · 0.1 mg/kg q12h PO with food · PO · q12h · 10 days · Side effects were limited to hyperexcitation and nausea, did not lead to termination of therapy, and gradually dissipated during the second week.
To induce estrus · 0.1 mg/kg PO twice a day · PO · q12h · From 100 days after ovulation until the following proestrus · Results have been variable depending on dosage. Can significantly shorten the interoestrous interval.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

Pregnancy (unless abortion is desired)
Nursing mothers
Hypersensitivity to ergot derivatives

이상반응

Anxiety
Aggressiveness
Depression
Hyperexcitation
Whining
Escaping behavior
Anorexia
Vomiting
Nausea

약물 상호작용

Bromocriptine · May cause additive effects if used with metergoline
Cabergoline · May cause additive effects if used with metergoline
Cyproheptadine · May cause additive effects if used with metergoline
Metoclopramide · Use with metergoline may reduce the efficacy of both drugs and should be avoided
SSRIs (e.g., fluoxetine, paroxetine, sertraline) · Potentially could reduce the efficacy of each drug

모니터링

Clinical efficacy (resolution of pseudopregnancy signs)
Adverse behavioral or GI effects
Liver function tests (if used long-term)

과용량

Little information is available regarding acute toxicity. **Vomiting** is the most likely clinical sign expected in an overdose situation. Treatment should be supportive and symptomatic.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.