메티라폰

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Known hypersensitivity to metyrapone
• Primary adrenal cortical insufficiency (Addison's disease)

이상반응

• Nausea
• Vomiting
• Abdominal pain
• Headache (reported in humans)
• Dizziness (reported in humans)
• Sedation (reported in humans)
• Allergic rash (reported in humans)
• Bone marrow depression (rare)

약물 상호작용

• Acetaminophen · Increased risk for acetaminophen toxicity. Note: Acetaminophen is strictly contraindicated in cats due to fatal methemoglobinemia and hepatotoxicity.
• Corticosteroids · Decreases the efficacy of metyrapone by suppressing ACTH and interfering with the diagnostic or therapeutic intent.

모니터링

• Blood glucose levels (critical in diabetic cats)
• Clinical signs of hyperadrenocorticism (to assess efficacy)
• Clinical signs of hypoadrenocorticism/Addisonian crisis (lethargy, vomiting, collapse)
• Electrolytes (sodium, potassium)

과용량

Acute toxicity data indicates an oral LD50 in rats of 521 mg/kg. **Clinical Signs of Overdose**: * Gastrointestinal distress (severe vomiting/nausea) * **Acute adrenocortical insufficiency (Addisonian crisis)** * Hypoglycemia, hyponatremia, hypochloremia, hyperkalemia * Cardiac arrhythmias, hypotension, dehydration, and altered mentation **Treatment**: * No specific antidote exists. * Standard gastrointestinal decontamination protocols if ingestion is recent. * Intravenous fluid therapy (saline) supplemented with **glucose**. * Administration of **intravenous hydrocortisone** or dexamethasone to replace depleted corticosteroids. * Intensive monitoring and supportive care for several days may be required.