미볼레론

안드로겐 / 단백동화 스테로이드

미볼레론은 강력한 **안드로겐, 단백동화 및 항성선자극호르몬** 작용을 하는 19-노르스테로이드입니다. * 과거 Cheque® Drops로 판매되었으나 현재는 상용 제품을 구하기 어려워 주로 조제 약국을 통해 공급되며, 미국에서는 **3급 통제 물질(Schedule III)**로 분류됩니다. * **임상적 용도**로는 암컷 개의 발정 억제, 상상 임신(위임신) 및 중증 유루증 치료가 있습니다. > **경고:** 미볼레론은 고양이에게 치료 지수가 매우 좁고 독성이 강하므로 고양이 환자에게는 **절대 사용해서는 안 됩니다**.

작용 기전: Mibolerone exerts its effects via a **negative feedback mechanism** on the anterior pituitary gland. * **Blocks luteinizing hormone (LH)** release → prevents follicular maturation → inhibits ovulation and corpus luteum development. * The net result is the suppression of the estrous cycle if administered prior to (up to 30 days) the onset of proestrus. * After discontinuation, the next estrus typically occurs within 7-200 days (average 70 days).

동물 종별 용량

Dogs

Suppression of estrus · 0.5-11 kg: 30 micrograms (0.3 mL) PO per day; 12-22 kg: 60 micrograms (0.6 mL) PO per day; 23-45 kg: 120 micrograms (1.2 mL) PO per day; >45 kg: 180 micrograms (1.8 mL) PO per day. German shepherds or German shepherd crosses: 180 micrograms (1.8 mL) PO per day; regardless of weight · PO · q24h · Treatment must begin at least 30 days prior to proestrus · If dog comes into estrus after receiving the drug for 30 or more days, stop drug and determine that the dog is not pregnant before resuming therapy. If owner compliance has been determined, increase dosage by 20-50%.
Pseudocyesis (false pregnancy) · 10 times the dosage listed above for suppression of estrus · PO · q24h · 5 days
Pseudocyesis (false pregnancy) · 16 micrograms/kg · PO · q24h · 5 days
Cystic endometrial hyperplasia (CEH) · 30 micrograms/25lb. body weight · PO · q24h · 6 months
Treatment of severe galactorrhea · 8-18 micrograms/kg · PO · q24h · 5 days · Once discontinued, prolactin may surge and galactorrhea resume.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

Perianal adenoma or perianal adenocarcinoma
Other androgen-dependent neoplasias
Pregnant or lactating bitches
Patients with ongoing or a history of liver or kidney disease
Bedlington Terriers
Cats

이상반응

Premature epiphyseal closure (in prepuberal females)
Clitoral enlargement / hypertrophy
Vaginitis / Vulvovaginitis
Increased body odor
Abnormal behavior (e.g., riding/mounting behavior)
Urinary incontinence
Voice deepening
Enhanced clinical signs of seborrhea oleosa
Epiphora (tearing)
Hepatic changes (intranuclear hyaline bodies) and rare hepatic dysfunction
Increased kidney weight
Fatalities, thyroid dysfunction, and pancreatic dysfunction (in cats)

약물 상호작용

Phenytoin · Increased seizure activity has been reported in a dog previously controlled on phenytoin.
Progestins · Should generally not be used concurrently.
Estrogens · Should generally not be used concurrently.

모니터링

Clinical signs of estrus
Liver function tests (baseline, annual, or as needed)
Physical examination of genitalia

과용량

In dogs, the drug did not cause death in doses up to 30,000 micrograms/kg/day when administered to beagles for 28 days. In cats, dosages as low as 120 micrograms/day have resulted in fatalities.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.