๋ฏธ๋ค๋ ์ค์ผ / ๋ฐฑ์ ๋ฐ์ ๋ฆฐ
๋ฏธ๋ค๋ ์ค์ผ์ ์์ ์์ ์ถ์ถํ ํฌ๋ช ํ๊ณ ๋ฌด์ ๋ฌด์ทจ์ธ ๋ณตํฉ ํํ์์ ํผํฉ๋ฌผ์ ๋๋ค. ์์ํ์์๋ ๊ณ ์ ์ ์ธ **์คํ์ฑ ํ์ **๋ก, ํนํ ๋๋๋ฌผ(๋ง ๋ฑ)์ ๋๊ฒฐ์ฅ ์ฐํต ๋ฐ ๋ชจ๋ ์ฐํต ์น๋ฃ์ ๋๋ฆฌ ์ฌ์ฉ๋ฉ๋๋ค. ์๋๋ฌผ์์๋ ์ฃผ๋ก ๊ณ ์์ด์ ๋ชจ๊ตฌ(ํค์ด๋ณผ)๋ฅผ ๊ด๋ฆฌํ๊ฑฐ๋ ์๋ฐฉํ๊ธฐ ์ํด ํฅ์ด ์ฒจ๊ฐ๋ ๋ฐ์ ๋ฆฐ ๊ฒ ํํ๋ก ์ฌ์ฉ๋ฉ๋๋ค. ๋ํ, ํน์ ์ง์ฉ์ฑ ๋ ์(์: ๋ฉํ์๋ฐํ์ด๋, ๋ฑ์ )์ ์์ฅ๊ด ํก์๋ฅผ ์ง์ฐ์ํค๊ธฐ ์ํด ์๊ด์ ํตํด ํฌ์ฌํ ์ ์์ต๋๋ค. > **์์ ์์ :** ์๋ฃ์ฉ์ผ๋ก๋ ๊ฒฝ์ง ๋ฏธ๋ค๋ ์ค์ผ๋ณด๋ค ์ค์ง ๋ฏธ๋ค๋ ์ค์ผ์ด ๊ถ์ฅ๋ฉ๋๋ค. ์ด๋ ๊ฒฝ๊ตฌ ํฌ์ฌ ํ ์ฅ์์ ํก์๋๊ฑฐ๋ ์ค์ฐ๋ ์ํ์ด ๋ ๋ฎ๊ธฐ ๋๋ฌธ์ ๋๋ค.
์์ฉ ๊ธฐ์ : Mineral oil and petrolatum act purely mechanically within the gastrointestinal tract: * **Lubrication:** Coats the intestinal mucosa and the fecal mass, reducing friction. * **Moisture Retention:** Creates a hydrophobic barrier that prevents the reabsorption of water from the GI tract โ increases fecal bulk and softens the stool. * **Transit Time:** The increased bulk and lubrication stimulate peristalsis โ decreases intestinal transit time. * **Toxin Sequestration:** Acts as an indigestible lipid sink in the gut lumen, trapping lipid-soluble toxins and preventing their systemic absorption.
๋๋ฌผ ์ข ๋ณ ์ฉ๋
- Laxative ยท 100-500 mL ยท Stomach tube
- Laxative ยท 100-500 mL ยท Stomach tube
- Laxative ยท 2-10 mL ยท PO ยท Because of the risk for aspiration, liquid mineral oil is rarely recommended for PO administration today.
- Laxative ยท 2-6 mL ยท PO
- Laxative ยท 5 mL ยท PO ยท q24h ยท Give per day with food
- Laxative ยท 1-4 liters ยท Stomach tube
- Laxative (Adults) ยท 0.5-2 liters ยท Stomach tube
- Laxative (Calves) ยท 60-120 mL ยท Stomach tube
- Adjunctive treatment of metaldehyde poisoning ยท 8 mL/kg ยท Stomach tube ยท May be used with a saline cathartic
- Adjunctive treatment of nitrate poisoning ยท 1 liter per 400 kg body weight ยท Stomach tube
ํฌ์ฌ ๊ฒฝ๋ก
๊ธ๊ธฐ
- Patients with an increased risk of vomiting or regurgitation
- Dysphagia or swallowing difficulties
- Esophageal or gastric retention
- Hiatal hernia
- Debilitated or pregnant patients (based on human guidelines)
- Human pediatric patients under 6 years old
์ด์๋ฐ์
- Lipid pneumonitis (severe, if aspirated)
- Granulomatous reactions in liver, spleen, and mesenteric lymph nodes (if absorbed)
- Anal oil leakage
- Decreased absorption of fat-soluble vitamins (A, D, E, K) with chronic use
์ฝ๋ฌผ ์ํธ์์ฉ
- Docusate (DSS) ยท Theoretically enhances the absorption of mineral oil, which could lead to systemic granulomatous reactions. Avoid concurrent use, though clinical significance in large animals appears low.
- Vitamins A, D, E, K ยท Chronic administration of mineral oil may decrease the absorption of fat-soluble vitamins. Administer between meals to minimize this effect.
๋ชจ๋ํฐ๋ง
- Clinical efficacy (fecal output, resolution of impaction)
- Signs of aspiration (coughing, tachypnea, dyspnea)
- Auscultation and thoracic radiographs if aspiration is suspected
๊ณผ์ฉ๋
Overdose effects are generally self-limiting (e.g., diarrhea, anal leakage). The primary life-threatening risk is **aspiration**, which can lead to severe lipid pneumonitis. Chronic overdosage may cause fat-soluble vitamin (A, D, E, K) deficiency.
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