미소프로스톨

동물 종별 용량

투여 경로

금기

• Pregnancy (unless being used specifically as an abortifacient)
• Nursing mothers (can cause severe diarrhea in nursing offspring)
• Known sensitivity to prostaglandins or prostaglandin analogs
• Pregnant animals (unless being used specifically to induce abortion)

이상반응

• Diarrhea
• Abdominal pain
• Vomiting
• Flatulence
• Uterine contractions (in females)
• Vaginal bleeding (in females)
• Diarrhoea
• Nausea
• Abortion

약물 상호작용

• Magnesium-containing antacids · May aggravate misoprostol-induced diarrhea. If an antacid is required, an aluminum-only antacid is preferred.
• Gentamicin · May exacerbate renal dysfunction · moderate
• Diclofenac · Human combination products (misoprostol + diclofenac) are highly toxic to small animals due to different NSAID pharmacokinetics · major

모니터링

• Clinical efficacy (resolution of ulcer signs, successful pregnancy termination, etc.)
• Adverse effects (GI distress, diarrhea, vomiting)
• Vaginal bleeding or discharge (if used in females)
• Resolution of clinical signs of gastric ulceration (e.g., vomiting, melena, anorexia)
• Monitoring for adverse GI effects (diarrhoea, abdominal pain)

과용량

Information on acute toxicity is limited. Overdoses in laboratory animals have produced: * Diarrhea and emesis * GI lesions * Tremors and seizures * Focal cardiac, hepatic, or renal tubular necrosis * Hypotension **Treatment:** Overdoses should be treated seriously. Employ standard gut-emptying techniques (e.g., emesis induction, activated charcoal) when applicable and safe. Treat resultant toxicity symptomatically with supportive care (e.g., IV fluids for hypotension and GI fluid loss).