๋ชจ๋ํ ํ๋ฅดํ๋ฅด์ฐ์ผ
**๋ชจ๋ํ ํ๋ฅดํ๋ฅด์ฐ์ผ(Morantel tartrate)**์ ์ฃผ๋ก ๋ฐ์ถ๋๋ฌผ(์, ์, ์ผ์)์ ์ฑ์ํ ์์ฅ๊ด ์ ์ถฉ์ ์ ๊ฑฐํ๋ ๋ฐ ์ฌ์ฉ๋๋ ํ ํธ๋ผํ๋๋กํผ๋ฆฌ๋ฏธ๋๊ณ ๊ตฌ์ถฉ์ ์ ๋๋ค. * **์ฃผ์ ํ์ **: ์ผ์ ์์ถฉ(*Haemonchus spp.*), ์ค์คํ ๋ฅดํ๊ธฐ์(*Ostertagia spp.*), ๋ชจ์์ ์ถฉ(*Trichostrongylus spp.*), ์ธ๊ฒฝ์ ์ถฉ(*Nematodirus spp.*), ์ฟ ํ๋ฆฌ์(*Cooperia spp.*) ๋ฐ ๋ฐฉ์ฌ์ฅ๊ฒฐ์ ์ถฉ(*Oesophagostomum radiatum*)์ ์ฑ์ถฉ. * **์์ ์์ **: ํผ๋ํ ๊ณผ ๋ฐ์ ํ ๊ด๋ จ์ด ์์ผ๋ฉฐ, ๋ชจ๋ํ ์ ๋ฐ์ถ๋๋ฌผ์ฉ์ผ๋ก ํน๋ณํ ์ ์กฐ๋์์ต๋๋ค. ์์ ์ญ์ด ๋งค์ฐ ๋์ผ๋ฉฐ ์์ ์ค์ธ ๋๋ฌผ์๊ฒ๋ ์ผ๋ฐ์ ์ผ๋ก ์์ ํ๊ฒ ์ฌ์ฉํ ์ ์์ต๋๋ค.
์์ฉ ๊ธฐ์ : Morantel acts as a **depolarizing neuromuscular blocking agent** in susceptible parasites. * **Nicotinic Agonist**: It possesses nicotine-like properties, mimicking **acetylcholine** at the parasite's neuromuscular junction โ continuous depolarization โ spastic paralysis of the worm โ expulsion from the host's GI tract. * **Enzyme Inhibition**: It also inhibits **fumarate reductase** in *Haemonchus spp.*, disrupting the parasite's energy metabolism. > **Note**: Morantel has a slower onset of action compared to pyrantel but is approximately 100 times more potent.
๋๋ฌผ ์ข ๋ณ ์ฉ๋
- Susceptible parasites ยท 10 mg/kg ยท PO ยท Single dose
- Susceptible parasites ยท 0.44 grams morantel tartrate per 100 lb. body weight ยท PO ยท Single dose ยท As a single therapeutic treatment. Conditions of constant worm exposure may require retreatment in 2-4 weeks.
- Susceptible parasites ยท 10 mg/kg ยท PO ยท Single dose
- Susceptible parasites ยท 9.68 mg/kg ยท PO ยท Single dose
- Susceptible parasites ยท 0.44 grams of morantel tartrate per 100 lbs of body weight ยท PO ยท Single dose ยท Feed at the rate of 10 lbs of premix per ton of food per 100 lbs of body weight.
- Susceptible parasites ยท 8.8 mg/kg ยท PO ยท Single dose
์ฉ๋์ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์ฐธ๊ณ ์๋ฃ์ ๋๋ค. ํญ์ ์ต์ ๋ผ๋ฒจ๊ณผ ๊ฐ๋ณ ํ์์ ๋ํด ํ์ธํ์ญ์์ค.
ํฌ์ฌ ๊ฒฝ๋ก
๊ธ๊ธฐ
- No absolute contraindications
์ด์๋ฐ์
- Increased respiratory rates (at high doses)
- Profuse sweating (at high doses)
- Ataxia (at high doses)
- Cholinergic effects (at high doses)
์ฝ๋ฌผ ์ํธ์์ฉ
- Bentonite ยท Do not add to feeds containing bentonite.
- Levamisole ยท Similar mechanism of action and toxicity; not recommended for concurrent use.
- Pyrantel ยท Similar mechanism of action and toxicity; not recommended for concurrent use.
- Organophosphates ยท Observation for adverse effects should be intensified if used concomitantly.
- Diethylcarbamazine ยท Observation for adverse effects should be intensified if used concomitantly.
- Piperazine ยท Has antagonistic mechanism of action; do not use with morantel.
๋ชจ๋ํฐ๋ง
- Efficacy of parasite clearance (e.g., fecal egg counts)
- Signs of cholinergic toxicity (only if massive overdose is suspected)
๊ณผ์ฉ๋
Morantel tartrate has a **large safety margin**. * **Cattle**: Dosages of up to 200 mg/kg (20 times recommended dose) resulted in no toxic reactions. Cattle receiving 2.5 times recommended dose for 2 weeks showed no toxic signs. * **Sheep**: Doses of 4 times recommended were given with no detectable deleterious effects. * **Mice**: The LD50 is 5 grams/kg. **Clinical signs of toxicity** (if they occur) may include: * Increased respiratory rates * Profuse sweating (in species with sweat glands) * Ataxia * Other cholinergic effects
VetSheet ์ฝ๋ฌผ ๋ ํผ๋ฐ์ค๋ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์์ฌ๊ฒฐ์ ๋ณด์กฐ ๋๊ตฌ์ด๋ฉฐ, ์ ๋ฌธ์ ํ๋จ์ด๋ ์ ์กฐ์ฌ์ ์ต์ ๋ผ๋ฒจ์ ๋์ ํ์ง ์์ต๋๋ค.