모란텔 타르타르산염

항기생충제 - 구충제 (테트라히드로피리미딘계)

**모란텔 타르타르산염(Morantel tartrate)**은 주로 반추동물(소, 양, 염소)의 성숙한 위장관 선충을 제거하는 데 사용되는 테트라히드로피리미딘계 구충제입니다. * **주요 표적**: 염전위충(*Haemonchus spp.*), 오스테르타기아(*Ostertagia spp.*), 모양선충(*Trichostrongylus spp.*), 세경선충(*Nematodirus spp.*), 쿠페리아(*Cooperia spp.*) 및 방사장결절충(*Oesophagostomum radiatum*)의 성충. * **임상 요점**: 피란텔과 밀접한 관련이 있으며, 모란텔은 반추동물용으로 특별히 제조되었습니다. 안전역이 매우 넓으며 임신 중인 동물에게도 일반적으로 안전하게 사용할 수 있습니다.

작용 기전: Morantel acts as a **depolarizing neuromuscular blocking agent** in susceptible parasites. * **Nicotinic Agonist**: It possesses nicotine-like properties, mimicking **acetylcholine** at the parasite's neuromuscular junction → continuous depolarization → spastic paralysis of the worm → expulsion from the host's GI tract. * **Enzyme Inhibition**: It also inhibits **fumarate reductase** in *Haemonchus spp.*, disrupting the parasite's energy metabolism. > **Note**: Morantel has a slower onset of action compared to pyrantel but is approximately 100 times more potent.

동물 종별 용량

Sheep

Susceptible parasites · 10 mg/kg · PO · Single dose

Goats

Susceptible parasites · 0.44 grams morantel tartrate per 100 lb. body weight · PO · Single dose · As a single therapeutic treatment. Conditions of constant worm exposure may require retreatment in 2-4 weeks.
Susceptible parasites · 10 mg/kg · PO · Single dose

Cattle

Susceptible parasites · 9.68 mg/kg · PO · Single dose
Susceptible parasites · 0.44 grams of morantel tartrate per 100 lbs of body weight · PO · Single dose · Feed at the rate of 10 lbs of premix per ton of food per 100 lbs of body weight.
Susceptible parasites · 8.8 mg/kg · PO · Single dose

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

No absolute contraindications

이상반응

Increased respiratory rates (at high doses)
Profuse sweating (at high doses)
Ataxia (at high doses)
Cholinergic effects (at high doses)

약물 상호작용

Bentonite · Do not add to feeds containing bentonite.
Levamisole · Similar mechanism of action and toxicity; not recommended for concurrent use.
Pyrantel · Similar mechanism of action and toxicity; not recommended for concurrent use.
Organophosphates · Observation for adverse effects should be intensified if used concomitantly.
Diethylcarbamazine · Observation for adverse effects should be intensified if used concomitantly.
Piperazine · Has antagonistic mechanism of action; do not use with morantel.

모니터링

Efficacy of parasite clearance (e.g., fecal egg counts)
Signs of cholinergic toxicity (only if massive overdose is suspected)

과용량

Morantel tartrate has a **large safety margin**. * **Cattle**: Dosages of up to 200 mg/kg (20 times recommended dose) resulted in no toxic reactions. Cattle receiving 2.5 times recommended dose for 2 weeks showed no toxic signs. * **Sheep**: Doses of 4 times recommended were given with no detectable deleterious effects. * **Mice**: The LD50 is 5 grams/kg. **Clinical signs of toxicity** (if they occur) may include: * Increased respiratory rates * Profuse sweating (in species with sweat glands) * Ataxia * Other cholinergic effects

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.