난드롤론 데카노에이트
Nandrolone Decanoate
Nortestosterone decanoate
다른 이름: Deca-Durabolin · Nortestosterone decanoate · Nortestosterone decylate
VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
동물 종별 용량
🌎 NA — North America🌍 EU — Europe
개
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Adjunctive treatment of chronic idiopathic myelofibrosis | 2 mg/kg IM weekly | IM | weekly | 3 weeks | 🌎 NA |
| Disuse muscle atrophy secondary to immobilization | 1.5 mg/kg IM once weekly | IM | once weekly | up to 8 weeks | 🌎 NA |
| Treatment of anemia in patients with chronic renal failure | 1-1.5 mg/kg IM once weekly | IM | once weekly | May require 2-3 months to achieve beneficial effects | 🌎 NA |
| Treatment of anemia in patients with chronic renal failure | 5 mg/kg IM (maximum of 200 mg/week) every 2-3 weeks | IM | every 2-3 weeks | — | 🌎 NA |
| Treatment of metabolic and endocrine anemias | 5 mg/kg IM once weekly | IM | once weekly | — | 🌎 NA |
| Aplastic anemia | 1-3 mg/kg IM weekly | IM | weekly | — | 🌎 NA |
| Appetite stimulant | 5 mg/kg IM weekly | IM | weekly | — | 🌎 NA |
- Adjunctive treatment of chronic idiopathic myelofibrosis: Used with prednisolone (2-3 mg/kg PO once daily for 3-4 weeks, then tapered). If anemia does not respond, azathioprine may be added.
- Disuse muscle atrophy secondary to immobilization: Start from the day of surgery/immobilization.
- Treatment of anemia in patients with chronic renal failure: Evidence to support use is poor.
- Treatment of metabolic and endocrine anemias: Maximum of 200 mg. Most resolve with correction of underlying disease process.
- Appetite stimulant: Maximum 200 mg/week.
고양이
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| FeLV-induced anemia or as a general bone marrow stimulant | 10-20 mg IM once weekly | IM | once weekly | — | 🌎 NA |
| Chronic anemia secondary to feline cardiomyopathy | 50 mg IM weekly | IM | weekly | — | 🌎 NA |
- FeLV-induced anemia or as a general bone marrow stimulant: Is of questionable benefit.
파충류
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| To reduce protein catabolism in renal disease of lizard species | 1 mg/kg IM every 7-28 days | IM | every 7-28 days | — | 🌎 NA |
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
개요
난드롤론 데카노에이트는 주사용 단백동화 스테로이드로, 과거에는 특정 빈혈(예: 만성 신부전 속발성 빈혈) 환자의 적혈구 생성을 자극하거나 식욕 촉진제로 주로 사용되었습니다. 현대 수의학에서는 더 안전하고 효과적인 대체제(예: 에리스로포이에틴, 미르타자핀 등)가 있어 현재는 거의 권장되거나 사용되지 않습니다. 제3군 통제 약물(C-III)로 분류됩니다.
작용 기전
Nandrolone is a synthetic derivative of testosterone with enhanced anabolic and reduced androgenic properties.
- Anabolic Effects: Binds to intracellular androgen receptors (AR) → translocates to the nucleus → alters gene transcription. In the presence of adequate protein and calories, it promotes body tissue-building processes and reverses catabolism.
- Erythropoiesis Stimulation: Enhances red blood cell counts by directly stimulating red cell precursors in the bone marrow, increasing red cell 2,3-diphosphoglycerate (2,3-DPG), and stimulating erythropoietin (EPO) production in the kidneys.
- Endocrine Feedback: Suppresses endogenous testosterone release by inhibiting luteinizing hormone (LH). Large doses impede spermatogenesis via negative feedback inhibition of follicle-stimulating hormone (FSH).
- Metabolic Effects: Causes retention of nitrogen, sodium, potassium, and phosphorus, and decreases urinary excretion of calcium.
안전성·주의사항
금기사항
- Hepatic dysfunction
- Hypercalcemia
- History of myocardial infarction
- Pituitary insufficiency
- Prostate carcinoma
- Mammary carcinoma
- Benign prostatic hypertrophy (BPH)
- Nephrotic stage of nephritis
- Pregnancy (FDA Category X - known teratogen)
부작용
- Sodium, calcium, potassium, water, chloride, and phosphate retention
- Hepatotoxicity
- Behavioral changes (androgenic effects, e.g., increased aggression)
- Reproductive abnormalities (oligospermia, estrus suppression)
- Masculinization of female fetuses (teratogenic)
주의
Pregnancy Warning: FDA Category X. Anabolic steroids can cause masculinization of the fetus. The risk of use in pregnant animals clearly outweighs any possible benefit.
- Nursing Mothers: It is unknown if anabolic steroids are excreted in maternal milk. Due to the potential for serious adverse reactions in nursing offspring, a decision should be made to either discontinue nursing or discontinue the drug.
- Laboratory Alterations: Can decrease protein-bound iodine (PBI), thyroxine-binding globulin, and total T4 concentrations while increasing resin uptake of T3 and T4 (free thyroid hormones remain unaltered). Can decrease creatinine and creatine excretion, increase 17-ketosteroid excretion, alter blood glucose, suppress clotting factors (II, V, VII, X), and elevate liver enzymes (AST, ALT, ALP, bilirubin).
약물 상호작용
Anabolic agents may potentiate the effects of anticoagulants; monitoring of INR and dosage adjustment of the anticoagulant are recommended.
Anabolics may enhance the edema that can be associated with ACTH or adrenal steroid therapy.
Anabolics may decrease blood glucose and decrease insulin requirements; diabetic patients may need dosage adjustments.
모니터링
- Androgenic side effects (behavioral changes)
- Fluid and electrolyte status (especially sodium, potassium, calcium)
- Liver function tests (AST, ALT, ALP, bilirubin)
- Red blood cell count and indices
- Weight and appetite
약동학
흡수
Administered via deep intramuscular injection. The decanoate ester provides a slow release from the injection site.
분포
No specific veterinary information located.
대사
Metabolized in the liver.
배설
No specific veterinary information located.
과다투여
No specific information was located for this agent in veterinary species. In humans, sodium and water retention can occur after overdosage of anabolic steroids.
- Treatment: Treat supportively. Monitor liver function and electrolyte status should an inadvertent overdose be administered.
제품
제형
- Injectable solution (compounded, typically in sesame oil)
동물용의약품
- None commercially available in the USA. Potentially available from compounding pharmacies.
인용의약품
- None commercially available in the USA.
규제 현황
규제 데이터 없음: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
보관·안정성
Store at temperatures less than 40°C, preferably between 15-30°C (59-86°F). Protect from freezing and light.
보호자 정보
- 통제 약물：오남용의 위험이 있으므로 이 약물은 제3군 통제 약물(C-III)로 분류됩니다. 어린이의 손이 닿지 않는 안전한 곳에 보관하십시오.
- 부작용 관찰：반려동물에게 행동 변화(예: 공격성 증가), 부종 또는 황달(간 문제의 징후)이 나타나는지 주의 깊게 관찰하십시오.
- 정기 검진：치료 기간 동안 간 기능과 적혈구 수치를 모니터링하기 위해 정기적인 혈액 검사가 필요합니다.
VetSheet 의약품 참고자료는 수의사 전문가의 임상 의사결정 지원을 위한 것이며, 전문적 판단이나 제조사의 최신 약물 정보를 대체할 수 없습니다.