나프록센

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Active GI ulcers
• History of hypersensitivity to naproxen or other NSAIDs
• Pre-existing hematologic, renal, or hepatic disease

이상반응

• GI distress (anorexia, vomiting, diarrhea)
• Gastrointestinal ulcers and perforation
• Melena and bloody vomitus
• Renal effects (nephritis, nephrotic syndrome, fluid retention)
• Hepatic effects (increased liver enzymes)
• Hematologic effects (hypoproteinemia, decreased hematocrit, anemia)
• CNS effects (neuropathies, lethargy, depression)

약물 상호작용

• Aminoglycosides (gentamicin, amikacin) · Increased risk for nephrotoxicity
• Anticoagulants (heparin, LMWH, warfarin) · Increased risk for bleeding
• Aspirin · Decreased plasma levels of naproxen and increased likelihood of GI adverse effects (blood loss). Concomitant use is not recommended.
• Bisphosphonates (alendronate) · May increase risk for GI ulceration
• Corticosteroids · Concomitant administration significantly increases the risks for GI adverse effects and ulceration
• Furosemide · Naproxen may reduce the saluretic and diuretic effects of furosemide
• Highly protein bound drugs (phenytoin, valproic acid, sulfonamides) · Potential displacement leading to increased serum levels and duration of action of the displaced drug
• Methotrexate · Serious toxicity has occurred; use together with extreme caution
• Probenecid · May cause a significant increase in serum levels and half-life of naproxen

모니터링

• Analgesic/anti-inflammatory efficacy
• GI signs: appetite, feces (occult blood, diarrhea)
• PCV (packed cell volume) and hematocrit if indicated or on chronic therapy
• WBCs if indicated or on chronic therapy
• Renal and hepatic function panels (especially in dogs)

과용량

Toxicity is a major concern, particularly in dogs and cats. * **Dogs**: The reported oral LD50 is >1000 mg/kg, but clinical toxicity occurs at much lower doses. * **>5 mg/kg**: Gastrointestinal signs and GI ulceration. * **>25 mg/kg** (some dogs as low as 10 mg/kg): Significant renal damage. * **>50 mg/kg**: Neurologic signs. * **Clinical Signs**: Vomiting (often bloody), lethargy, anorexia, diarrhea, melena, anemia, and elevated renal/hepatic values. * **Treatment**: * **Decontamination**: Emesis and/or activated charcoal if recent ingestion. * **GI Protection**: Misoprostol and sucralfate are recommended for 10-14 days post-exposure. * **Renal Protection**: Fluid diuresis should be considered if renal effects are expected. * **Supportive Care**: Monitor electrolyte and fluid balance carefully; manage renal failure using established guidelines.