옥사실린

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Known hypersensitivity to penicillins
• Oral administration in patients with septicemia, shock, or other grave illnesses (due to delayed/diminished GI absorption)

이상반응

• Anorexia
• Vomiting
• Diarrhea
• Antibiotic-associated diarrhea and superinfections
• Hypersensitivity reactions (rash, fever, eosinophilia, anaphylaxis)
• Neurotoxicity (ataxia, CNS effects at very high doses)
• Elevated liver enzymes
• Tachypnea
• Dyspnea
• Edema
• Tachycardia

약물 상호작용

• Aminoglycosides · In vitro evidence of synergism against S. aureus strains; however, mixing in the same syringe/fluid line can cause physical inactivation.
• Cyclosporine · Oxacillin may reduce cyclosporine serum levels.
• Probenecid · Competitively blocks the tubular secretion of oxacillin, thereby increasing serum levels and prolonging serum half-life.
• Tetracyclines · Theoretical antagonism (bacteriostatic drugs may interfere with bactericidal action of penicillins); concurrent use is usually not recommended.
• Warfarin · Oxacillin may cause decreased warfarin efficacy.

모니터링

• Clinical efficacy (resolution of infection)
• Signs of adverse effects (GI upset, allergic reactions)

과용량

Acute oral overdoses are unlikely to cause significant problems other than **gastrointestinal distress** (vomiting, diarrhea). In humans, very high dosages of parenteral penicillins, especially in patients with compromised renal function, have induced **CNS effects and neurotoxicity**.