옥사제팜

동물 종별 용량

투여 경로

금기

• Known benzodiazepine hypersensitivity
• Acute narrow angle glaucoma

이상반응

• Sedation (most common)
• Ataxia
• Paradoxical excitability, vocalization, or aggression
• Rebound anxiety or behavior worsening (if withdrawn abruptly)
• Rare precipitation of tonic-clonic seizures
• Rare idiosyncratic fulminant hepatic failure (cats)

약물 상호작용

• CNS Depressant Drugs (barbiturates, narcotics, anesthetics) · Additive CNS depression effects may occur.
• Phenytoin · May decrease oxazepam concentrations.
• Probenecid · May impair glucuronide conjugation (in dogs) and prolong effects.
• Rifampin · May induce hepatic microsomal enzymes and decrease the pharmacologic effects of benzodiazepines.
• St. John's Wort · May decrease oxazepam effectiveness.
• Theophyllines · May decrease oxazepam effectiveness.

모니터링

• Clinical efficacy (improved appetite, reduced anxiety/fear)
• Adverse effects (degree of sedation, ataxia, paradoxical excitement)

과용량

**Signs of Toxicity:** When used alone, overdoses are generally limited to significant CNS depression (confusion, coma, decreased reflexes, profound sedation). **Treatment:** * **Decontamination:** Standard protocols for removing and/or binding the drug in the gut (e.g., emesis induction if asymptomatic and recent, activated charcoal) if taken orally. * **Supportive Care:** Systemic supportive measures (IV fluids, warming, respiratory support if needed). * **Antidote:** **Flumazenil** (a specific benzodiazepine antagonist) could potentially be used in life-threatening overdoses. * **Contraindications:** The use of analeptic agents (CNS stimulants such as caffeine, amphetamines) is generally not recommended.